New Positions
4 managers initiated
Top five by reported value
- TWO SIGMA ADVISERS, LP$35.9K
- XTX Topco Ltd$12.7K
- CITIGROUP INC$10.4K
- WHI TRUST Co LLC$91
Cyclerion Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:CYCN
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
4 new5 added10 reduced2 exited
Total Institutional Holders
19
as of 2025-12-31
Top Holder
Siren, L.L.C.
$146.8K
Largest QoQ Increase
TWO SIGMA ADVISERS, LP
+28,300 sh
Largest QoQ Decrease
DRW Securities, LLC
-43,617 sh
New Positions(4)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TWO SIGMA ADVISERS, LP | 28,300 | +28,300 | $35.9K | +$35.9K | — |
| XTX Topco Ltd | 10,027 | +10,027 | $12.7K | +$12.7K | — |
| CITIGROUP INC | 8,204 | +8,204 | $10.4K | +$10.4K | — |
| WHI TRUST Co LLC | 72 | +72 | $91 | +$91 | — |
Added To(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GEODE CAPITAL MANAGEMENT, LLC | 43,302 | +6,144 | $55.0K | -$30.5K | 16.5% |
| TWO SIGMA INVESTMENTS, LP | 41,555 | +28,262 | $52.8K | +$22.2K | 212.6% |
| Tower Research Capital LLC (TRC) | 3,154 | +826 | $4.0K | -$1.3K | 35.5% |
| UBS Group AG | 376 | +327 | $478 | +$365 | 667.3% |
| BANK OF AMERICA CORP /DE/ | 107 | +85 | $136 | +$86 | 386.4% |
Reduced(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Siren, L.L.C. | 115,603 | -552 | $146.8K | -$120.3K | -0.5% |
| VANGUARD GROUP INC | 23,490 | 0 | $29.8K | -$24.2K | 0.0% |
| BlackRock, Inc. | 16,797 | 0 | $21.3K | -$17.3K | 0.0% |
| FMR LLC | 4,740 | -6 | $6.0K | -$4.9K | -0.1% |
| MORGAN STANLEY | 1 | -648 | $2 | -$1.5K | -99.8% |
| GROUP ONE TRADING, L.P. | 192 | 0 | $244 | -$198 | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 130 | 0 | $165 | -$139 | 0.0% |
| MAI Capital Management | 100 | 0 | $127 | -$103 | 0.0% |
| Activest Wealth Management | 100 | 0 | $127 | -$103 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 5 | 0 | $6 | -$6 | 0.0% |
Sold Out(2)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DRW Securities, LLC | 0 | -43,617 | $0 | -$100.3K | — |
| BARCLAYS PLC | 0 | -5 | $0 | -$12 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Siren, L.L.C. | 115,603 | $146.8K | -552 | -0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 43,302 | $55.0K | +6,144 | 16.5% |
| TWO SIGMA INVESTMENTS, LP | 41,555 | $52.8K | +28,262 | 212.6% |
| TWO SIGMA ADVISERS, LP | 28,300 | $35.9K | +28,300 | — |
| VANGUARD GROUP INC | 23,490 | $29.8K | 0 | 0.0% |
| BlackRock, Inc. | 16,797 | $21.3K | 0 | 0.0% |
| XTX Topco Ltd | 10,027 | $12.7K | +10,027 | — |
| CITIGROUP INC | 8,204 | $10.4K | +8,204 | — |
| FMR LLC | 4,740 | $6.0K | -6 | -0.1% |
| Tower Research Capital LLC (TRC) | 3,154 | $4.0K | +826 | 35.5% |
| UBS Group AG | 376 | $478 | +327 | 667.3% |
| GROUP ONE TRADING, L.P. | 192 | $244 | 0 | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 130 | $165 | 0 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 107 | $136 | +85 | 386.4% |
| Activest Wealth Management | 100 | $127 | 0 | 0.0% |
| MAI Capital Management | 100 | $127 | 0 | 0.0% |
| WHI TRUST Co LLC | 72 | $91 | +72 | — |
| BNP PARIBAS ARBITRAGE, SNC | 5 | $6 | 0 | 0.0% |
| MORGAN STANLEY | 1 | $2 | -648 | -99.8% |
New & Closed Positions this quarter
Closed Positions
2 managers exited
Top five by prior-quarter value
- DRW Securities, LLC$100.3K
- BARCLAYS PLC$12
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for CYCN against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.