| TANG CAPITAL MANAGEMENT LLC | 0 | -3,812,773 | $0 | -$1.5M | — |
| Vivo Capital, LLC | 0 | -3,521,291 | $0 | -$1.4M | — |
| Sofinnova Investments, Inc. | 0 | -2,754,437 | $0 | -$1.1M | — |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | -1,891,467 | $0 | -$756.6K | — |
| VANGUARD GROUP INC | 0 | -1,169,705 | $0 | -$467.9K | — |
| Nan Fung Group Holdings Ltd | 0 | -1,166,952 | $0 | -$466.8K | — |
| SAMSARA BIOCAPITAL, LLC | 0 | -1,049,153 | $0 | -$419.7K | — |
| Board of Trustees of The Leland Stanford Junior University | 0 | -719,546 | $0 | -$287.8K | — |
| Pfizer Inc | 0 | -626,109 | $0 | -$250.4K | — |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | -375,113 | $0 | -$150.1K | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -314,139 | $0 | -$125.7K | — |
| BlackRock, Inc. | 0 | -268,640 | $0 | -$107.5K | — |
| ADAR1 Capital Management, LLC | 0 | -244,966 | $0 | -$98.0K | — |
| UBS Group AG | 0 | -111,508 | $0 | -$44.6K | — |
| STATE STREET CORP | 0 | -47,437 | $0 | -$19.0K | — |
| NORTHERN TRUST CORP | 0 | -40,895 | $0 | -$16.4K | — |
| Mariner, LLC | 0 | -40,000 | $0 | -$16.0K | — |
| MORGAN STANLEY | 0 | -23,231 | $0 | -$10.9K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | -21,733 | $0 | -$8.7K | — |
| XTX Topco Ltd | 0 | -15,392 | $0 | -$6.2K | — |
| Tower Research Capital LLC (TRC) | 0 | -8,688 | $0 | -$3.5K | — |
| FMR LLC | 0 | -8,100 | $0 | -$3.2K | — |
| BANK OF AMERICA CORP /DE/ | 0 | -5,628 | $0 | -$2.3K | — |
| JPMORGAN CHASE & CO | 0 | -906 | $0 | -$362 | — |
| SBI Securities Co., Ltd. | 0 | -200 | $0 | -$80 | — |
| SALEM INVESTMENT COUNSELORS INC | 0 | -40 | $0 | -$16 | — |
| BARCLAYS PLC | 0 | -139 | $0 | $0 | — |
| BNP PARIBAS FINANCIAL MARKETS | 0 | -1 | $0 | $0 | — |