| BVF INC/IL | 19,822,436 | 0 | $62.2M | +$5.0M | 0.0% |
| WELLS FARGO & COMPANY/MN | 1,006,289 | -4,232 | $3.2M | +$239.3K | -0.4% |
| RENAISSANCE TECHNOLOGIES LLC | 668,867 | -101,552 | $2.1M | -$126.3K | -13.2% |
| MILLENNIUM MANAGEMENT LLC | 933,342 | -56,090 | $2.9M | +$71.2K | -5.7% |
| NORTHERN TRUST CORP | 281,953 | 0 | $885.3K | +$70.5K | 0.0% |
| Banque Cantonale Vaudoise | 7,892 | -10,548 | $25.0K | +$24.9K | -57.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 63,601 | 0 | $199.7K | +$15.9K | 0.0% |
| Royal Bank of Canada | 858 | -2,390 | $2.0K | -$4.0K | -73.6% |
| SEI INVESTMENTS CO | 15,884 | 0 | $49.9K | +$4.0K | 0.0% |
| Quinn Opportunity Partners LLC | 10,100 | 0 | $31.7K | +$2.5K | 0.0% |
| Silverberg Bernstein Capital Management LLC | 10,000 | 0 | $31.3K | +$2.4K | 0.0% |
| China Universal Asset Management Co., Ltd. | 16,362 | -1,238 | $51.4K | +$513 | -7.0% |
| BNP PARIBAS FINANCIAL MARKETS | 2,480 | -323 | $7.8K | -$314 | -11.5% |
| Rockefeller Capital Management L.P. | 1,000 | 0 | $3.1K | +$250 | 0.0% |
| Activest Wealth Management | 1,000 | 0 | $3.1K | +$250 | 0.0% |
| SBI Securities Co., Ltd. | 547 | -1 | $1.7K | +$134 | -0.2% |
| Strengthening Families & Communities, LLC | 200 | 0 | $628 | +$50 | 0.0% |
| GF FUND MANAGEMENT CO. LTD. | 1,972 | -188 | $6.2K | -$50 | -8.7% |
| OSAIC HOLDINGS, INC. | 221 | -30 | $693 | -$31 | -11.9% |