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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F Institutional Ownership · ACHV

Achieve Life Sciences Inc NASDAQ NMS - GLOBAL MARKET:ACHV

Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.

23 new26 added31 reduced13 exited

New Positions(23)

ManagerSharesΔ SharesValueΔ Value% Δ
KVP Capital Advisors, LP462,355+462,355$2.3M+$2.3M
683 Capital Management, LLC214,897+214,897$1.1M+$1.1M
Alpine Global Management, LLC83,481+83,481$414.9K+$414.9K
Point72 Asset Management, L.P.75,169+75,169$373.6K+$373.6K
Hudson Bay Capital Management LP67,663+67,663$336.3K+$336.3K
Graham Capital Management, L.P.42,723+42,723$212.3K+$212.3K
CITIGROUP INC32,968+32,968$163.9K+$163.9K
MEMBERS WEALTH LLC30,000+30,000$152.7K+$152.7K
Keating Financial Advisory Services, Inc.24,911+24,911$123.8K+$123.8K
Goldstone Financial Group, LLC24,163+24,163$120.1K+$120.1K
Lighthouse Investment Partners, LLC23,700+23,700$117.8K+$117.8K
Jump Financial, LLC21,000+21,000$104.4K+$104.4K
SIMPLEX TRADING, LLC17,338+17,338$86.2K+$86.2K
Jefferies Financial Group Inc.16,813+16,813$83.6K+$83.6K
MAGNOLIA CAPITAL ADVISORS LLC12,850+12,850$63.9K+$63.9K
Steward Partners Investment Advisory, LLC4,640+4,640$23.1K+$23.1K
Allworth Financial LP3,000+3,000$14.9K+$14.9K
Torren Management, LLC2,870+2,870$14.3K+$14.3K
Tower Research Capital LLC (TRC)2,826+2,826$14.0K+$14.0K
JONES FINANCIAL COMPANIES LLLP200+200$994+$994
HRT FINANCIAL LP18,858+18,858$93+$93
Parkside Financial Bank & Trust5+5$25+$25
FNY Investment Advisers, LLC5,000+5,000$15+$15

Added To(26)

ManagerSharesΔ SharesValueΔ Value% Δ
FRANKLIN RESOURCES INC4,369,193+4,346,011$21.7M+$21.7M18747.3%
MILLENNIUM MANAGEMENT LLC1,359,116+1,121,614$6.8M+$6.0M472.3%
VANGUARD GROUP INC2,474,312+12,510$12.3M+$4.5M0.5%
MARSHALL WACE, LLP1,019,281+244,428$5.1M+$2.6M31.5%
TWO SIGMA INVESTMENTS, LP748,616+309,552$3.7M+$2.3M70.5%
LPL Financial LLC633,148+301,850$3.1M+$2.1M91.1%
JANE STREET GROUP, LLC395,811+320,911$2.0M+$1.7M428.4%
RAYMOND JAMES FINANCIAL INC599,679+143,307$3.0M+$1.5M31.4%
GOLDMAN SACHS GROUP INC450,928+227,095$2.2M+$1.5M101.5%
GEODE CAPITAL MANAGEMENT, LLC599,611+92,634$3.0M+$1.4M18.3%
SUSQUEHANNA INTERNATIONAL GROUP, LLP554,250+96,087$2.8M+$1.3M21.0%
UBS Group AG285,229+206,087$1.4M+$1.2M260.4%
BlackRock, Inc.419,133+27,893$2.1M+$850.7K7.1%
BNP PARIBAS ARBITRAGE, SNC167,945+167,635$834.7K+$833.7K54075.8%
TWO SIGMA ADVISERS, LP209,900+99,600$1.0M+$695.8K90.3%
STATE STREET CORP234,257+13,873$1.2M+$470.0K6.3%
NORTHERN TRUST CORP229,879+10,434$1.1M+$451.2K4.8%
CITADEL ADVISORS LLC110,900+55,600$551.2K+$377.0K100.5%
MORGAN STANLEY79,061+45,414$392.9K+$286.9K135.0%
ADVISOR GROUP HOLDINGS, INC.53,983+25,550$268.3K+$182.3K89.9%
MANCHESTER FINANCIAL INC59,084+12,410$293.6K+$146.6K26.6%
Robertson Stephens Wealth Management, LLC20,000+10,000$99.4K+$67.9K100.0%
SBI Securities Co., Ltd.14,041+1$69.8K+$25.6K0.0%
Cornerstone Planning Group LLC100+87$436-$4.2K669.2%
BARCLAYS PLC1,716+1,715$3.9K+$3.9K171500.0%
Capital Analysts, LLC700+190$3+$137.3%

Reduced(31)

ManagerSharesΔ SharesValueΔ Value% Δ
Propel Bio Management, LLC3,786,4250$18.8M+$6.9M0.0%
Simplify Asset Management Inc.1,184,5120$5.9M+$2.2M0.0%
Nantahala Capital Management, LLC648,8850$3.2M+$1.2M0.0%
Squarepoint Ops LLC164,605-208,474$818.1K-$357.1K-55.9%
Caption Management, LLC67,695-132,305$336.4K-$293.6K-66.2%
Pathstone Holdings, LLC416,667-85,333$1.9M+$277.0K-17.0%
Royal Bank of Canada1,536-118,276$8.0K-$263.0K-98.7%
Shay Capital LLC234,937-54,608$1.2M+$255.6K-18.9%
RENAISSANCE TECHNOLOGIES LLC152,460-158,304$757.7K-$221.2K-50.9%
XTX Topco Ltd19,092-66,763$94.9K-$175.6K-77.8%
CHARLES SCHWAB INVESTMENT MANAGEMENT INC20,000-69,562$99.4K-$139.7K-77.7%
WELLS FARGO & COMPANY/MN70,059-1,537$348.2K+$122.7K-2.1%
Ronald Blue Trust, Inc.85,888-13,242$426.9K+$114.6K-13.3%
DIMENSIONAL FUND ADVISORS LP52,4200$260.5K+$95.4K0.0%
Qube Research & Technologies Ltd13,405-36,261$66.6K-$89.8K-73.0%
ADAR1 Capital Management, LLC47,8000$237.6K+$87.0K0.0%
Rockefeller Capital Management L.P.30,0000$149.1K+$54.6K0.0%
BANK OF AMERICA CORP /DE/24,054-23,355$119.5K-$29.8K-49.3%
Next Capital Management LLC16,1300$80.2K+$29.4K0.0%
Windsor Capital Management, LLC10,8170$53.8K+$19.7K0.0%
Madison Park Capital Advisors, LLC10,0000$49.7K+$18.2K0.0%
FMR LLC6,513-473$32.4K+$10.4K-6.8%
COMERICA BANK2,382-31$11.8K+$4.2K-1.3%
Federation des caisses Desjardins du Quebec2,0000$9.9K+$3.6K0.0%
Optiver Holding B.V.4900$2.4K+$8910.0%
SITTNER & NELSON, LLC6730$2.9K+$7410.0%
Russell Investments Group, Ltd.1500$746+$2730.0%
IFP Advisors, Inc00$35+$35
JPMORGAN CHASE & CO190$94+$340.0%
SRS Capital Advisors, Inc.100$50+$190.0%
CWM, LLC1,7020$8+$30.0%

Sold Out(13)

ManagerSharesΔ SharesValueΔ Value% Δ
Clearline Capital LP0-451,219$0-$1.4M
Alyeska Investment Group, L.P.0-178,389$0-$561.9K
NEW YORK STATE COMMON RETIREMENT FUND0-24,600$0-$112.5K
Cubist Systematic Strategies, LLC0-35,523$0-$111.9K
Sender Co & Partners, Inc.0-25,000$0-$78.8K
OMERS ADMINISTRATION Corp0-24,700$0-$77.8K
Resources Investment Advisors, LLC.0-20,000$0-$63.0K
BERKSHIRE ASSET MANAGEMENT LLC/PA0-17,700$0-$55.8K
GROUP ONE TRADING, L.P.0-8,796$0-$27.7K
Point72 Asia (Singapore) Pte. Ltd.0-7,505$0-$23.6K
Stephens Consulting, LLC0-3,000$0-$9.4K
PNC Financial Services Group, Inc.0-826$0-$2.6K
Point72 (DIFC) Ltd0-189$0-$595

Top Holders by reported value

Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.

ManagerShares$ ValueΔ SharesQoQ %
FRANKLIN RESOURCES INC4,369,193$21.7M+4,346,01118747.3%
Propel Bio Management, LLC3,786,425$18.8M00.0%
VANGUARD GROUP INC2,474,312$12.3M+12,5100.5%
MILLENNIUM MANAGEMENT LLC1,359,116$6.8M+1,121,614472.3%
Simplify Asset Management Inc.1,184,512$5.9M00.0%
MARSHALL WACE, LLP1,019,281$5.1M+244,42831.5%
TWO SIGMA INVESTMENTS, LP748,616$3.7M+309,55270.5%
Nantahala Capital Management, LLC648,885$3.2M00.0%
LPL Financial LLC633,148$3.1M+301,85091.1%
GEODE CAPITAL MANAGEMENT, LLC599,611$3.0M+92,63418.3%
RAYMOND JAMES FINANCIAL INC599,679$3.0M+143,30731.4%
SUSQUEHANNA INTERNATIONAL GROUP, LLP554,250$2.8M+96,08721.0%
KVP Capital Advisors, LP462,355$2.3M+462,355
GOLDMAN SACHS GROUP INC450,928$2.2M+227,095101.5%
BlackRock, Inc.419,133$2.1M+27,8937.1%
JANE STREET GROUP, LLC395,811$2.0M+320,911428.4%
Pathstone Holdings, LLC416,667$1.9M-85,333-17.0%
UBS Group AG285,229$1.4M+206,087260.4%
Shay Capital LLC234,937$1.2M-54,608-18.9%
STATE STREET CORP234,257$1.2M+13,8736.3%

New & Closed Positions this quarter

Methodology

Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.

Quarter-over-quarter deltas compare each manager's most recently reported share count for ACHV against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.

Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.