13F HOLDINGS REPORT
Paradigm Biocapital Advisors LP
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001855655-25-000014
Total Value
$3.52B
Positions
36
Other Managers
0
Confidential Omitted
No
Holdings (36)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | NUVALENT INC | NUVL | 5,269,433 | $455.7M | 12.96% |
| 2 | MERUS N V | N5749R100 | 4,373,770 | $411.8M | 11.71% |
| 3 | ARCELLX INC | ACLX | 4,649,016 | $381.7M | 10.86% |
| 4 | REVOLUTION MEDICINES INC | RVMDW | 6,223,291 | $290.6M | 8.27% |
| 5 | TARSUS PHARMACEUTICALS INC | TARS | 2,665,698 | $158.4M | 4.51% |
| 6 | VAXCYTE INC | PCVX | 3,784,755 | $136.3M | 3.88% |
| 7 | ABIVAX SA | AAVXF | 1,564,196 | $132.8M | 3.78% |
| 8 | GENMAB A/S | GNMSF | 3,816,851 | $117.1M | 3.33% |
| 9 | AGIOS PHARMACEUTICALS INC | AGIO | 2,673,555 | $107.3M | 3.05% |
| 10 | CRINETICS PHARMACEUTICALS IN | CRNX | 2,550,774 | $106.2M | 3.02% |
| 11 | SPDR SERIES TRUST | 78464A870 | 1,000,000 | $100.2M | 2.85% |
| 12 | EDGEWISE THERAPEUTICS INC | EWTX | 6,170,131 | $100.1M | 2.85% |
| 13 | CIDARA THERAPEUTICS INC | 171757206 | 961,164 | $92.0M | 2.62% |
| 14 | UROGEN PHARMA LTD | URGN | 4,216,084 | $84.1M | 2.39% |
| 15 | SCHOLAR ROCK HLDG CORP | SRRK | 2,009,745 | $74.8M | 2.13% |
| 16 | JANUX THERAPEUTICS INC | JANX | 2,920,258 | $71.4M | 2.03% |
| 17 | OLEMA PHARMACEUTICALS INC | OLMA | 6,794,172 | $66.5M | 1.89% |
| 18 | APOGEE THERAPEUTICS INC | APGE | 1,521,757 | $60.5M | 1.72% |
| 19 | VIRIDIAN THERAPEUTICS INC | VRDN | 2,609,353 | $56.3M | 1.60% |
| 20 | ALKERMES PLC | ALKS | 1,719,334 | $51.6M | 1.47% |
| 21 | LENZ THERAPEUTICS INC | LENZ | 1,073,461 | $50.0M | 1.42% |
| 22 | PHARVARIS N V | PHVS | 1,835,494 | $45.8M | 1.30% |
| 23 | COGENT BIOSCIENCES INC | COGT | 3,156,398 | $45.3M | 1.29% |
| 24 | OCULAR THERAPEUTIX INC | OCUL | 3,497,307 | $40.9M | 1.16% |
| 25 | BRIDGEBIO PHARMA INC | BBIO | 684,277 | $35.5M | 1.01% |
| 26 | ERASCA INC | ERAS | 13,560,017 | $29.6M | 0.84% |
| 27 | EYEPOINT PHARMACEUTICALS INC | EYPT | 2,005,365 | $28.6M | 0.81% |
| 28 | MERUS N V | N5749R100 | 300,000 | $28.2M | 0.80% |
| 29 | TANGO THERAPEUTICS INC | TNGX | 3,086,184 | $25.9M | 0.74% |
| 30 | AMYLYX PHARMACEUTICALS INC | AMLX | 1,900,000 | $25.8M | 0.73% |
| 31 | SPYRE THERAPEUTICS INC | SYRE | 1,467,266 | $24.6M | 0.70% |
| 32 | DYNE THERAPEUTICS INC | DYN | 1,898,950 | $24.0M | 0.68% |
| 33 | BRIDGEBIO ONCOLOGY THERAPEUT | BBOT | 1,866,141 | $21.6M | 0.61% |
| 34 | DISC MEDICINE INC | IRON | 247,716 | $16.4M | 0.47% |
| 35 | STRUCTURE THERAPEUTICS INC | GPCR | 372,869 | $10.4M | 0.30% |
| 36 | AGIOS PHARMACEUTICALS INC | AGIO | 200,000 | $8.0M | 0.23% |