13F HOLDINGS REPORT
Paradigm Biocapital Advisors LP
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001855655-26-000003
Total Value
$3.92B
Positions
30
Other Managers
0
Confidential Omitted
No
Holdings (30)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | NUVALENT INC | NUVL | 5,269,433 | $530.1M | 13.53% |
| 2 | REVOLUTION MEDICINES INC | RVMDW | 6,644,403 | $529.2M | 13.51% |
| 3 | ARCELLX INC | ACLX | 5,724,016 | $373.2M | 9.53% |
| 4 | GENMAB A/S | GNMSF | 7,039,834 | $216.8M | 5.53% |
| 5 | TARSUS PHARMACEUTICALS INC | TARS | 2,562,154 | $209.8M | 5.35% |
| 6 | ABIVAX SA | AAVXF | 1,417,473 | $191.2M | 4.88% |
| 7 | OLEMA PHARMACEUTICALS INC | OLMA | 7,544,172 | $188.6M | 4.81% |
| 8 | VAXCYTE INC | PCVX | 4,068,020 | $187.7M | 4.79% |
| 9 | SPDR SERIES TRUST | 78464A870 | 1,500,000 | $182.9M | 4.67% |
| 10 | CIDARA THERAPEUTICS INC | 171757206 | 759,565 | $167.8M | 4.28% |
| 11 | EDGEWISE THERAPEUTICS INC | EWTX | 6,541,210 | $162.3M | 4.14% |
| 12 | SCHOLAR ROCK HLDG CORP | SRRK | 3,062,157 | $134.9M | 3.44% |
| 13 | UROGEN PHARMA LTD | URGN | 4,473,648 | $104.8M | 2.67% |
| 14 | CRINETICS PHARMACEUTICALS IN | CRNX | 2,210,774 | $102.9M | 2.63% |
| 15 | APOGEE THERAPEUTICS INC | APGE | 1,123,243 | $84.8M | 2.16% |
| 16 | EYEPOINT INC | EYPT | 3,691,475 | $67.4M | 1.72% |
| 17 | ERASCA INC | ERAS | 14,159,095 | $52.7M | 1.34% |
| 18 | BRIDGEBIO PHARMA INC | BBIO | 684,277 | $52.3M | 1.34% |
| 19 | ORUKA THERAPEUTICS INC | ORKA | 1,710,316 | $51.8M | 1.32% |
| 20 | SPYRE THERAPEUTICS INC | SYRE | 1,467,266 | $48.1M | 1.23% |
| 21 | LEXEO THERAPEUTICS INC | LXEO | 4,763,198 | $47.3M | 1.21% |
| 22 | VIRIDIAN THERAPEUTICS INC | VRDN | 1,443,102 | $44.9M | 1.15% |
| 23 | OCULAR THERAPEUTIX INC | OCUL | 2,935,284 | $35.6M | 0.91% |
| 24 | TERNS PHARMACEUTICALS INC | TERN | 810,286 | $32.7M | 0.84% |
| 25 | BRIDGEBIO ONCOLOGY THERAPEUT | BBOT | 2,261,749 | $28.3M | 0.72% |
| 26 | VOR BIOPHARMA INC | VOR | 1,750,000 | $22.9M | 0.58% |
| 27 | ASSEMBLY BIOSCIENCES INC | ASMB | 665,251 | $22.6M | 0.58% |
| 28 | ORIC PHARMACEUTICALS INC | ORIC | 2,401,217 | $19.6M | 0.50% |
| 29 | INVENTIVA SA | IVEVF | 4,000,000 | $18.6M | 0.47% |
| 30 | KALARIS THERAPEUTICS INC | KLRS | 700,000 | $5.9M | 0.15% |