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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

Ikarian Capital, LLC

Quarter ended Q4 2025 · Filed February 18, 2026 · Accession 0001420506-26-000592

Total Value
$1.28B
Positions
174
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (174)

#IssuerTicker / CUSIPSharesValue% of Filing
1SPDR SERIES TRUST78464A870850,000$103.6M8.09%
2CIDARA THERAPEUTICS INC171757206300,000$66.3M5.17%
3AMGEN INCAMGN200,000$65.5M5.11%
4TERNS PHARMACEUTICALS INCTERN1,596,378$64.5M5.04%
5CIDARA THERAPEUTICS INC171757206273,243$60.4M4.71%
6ABIVAX SAAAVXF205,985$29.1M2.27%
7JAZZ PHARMACEUTICALS PLCJAZZ170,000$28.9M2.26%
8JAZZ PHARMACEUTICALS PLCJAZZ160,367$27.3M2.13%
9MAZE THERAPEUTICS INCMAZE644,680$26.7M2.09%
10PRAXIS PRECISION MEDICINES IPRAX86,581$25.5M1.99%
11HARROW INCHROW509,700$25.0M1.95%
12SOLENO THERAPEUTICS INCSLNO528,900$24.5M1.91%
13RAPT THERAPEUTICS INC75382E208665,271$22.5M1.76%
14KODIAK SCIENCES INCKOD719,787$20.1M1.57%
15OLEMA PHARMACEUTICALS INCOLMA758,654$19.0M1.48%
16CYTOKINETICS INCCYTK290,900$18.5M1.44%
17VAXCYTE INCPCVX378,682$17.5M1.36%
18CRINETICS PHARMACEUTICALS INCRNX368,500$17.2M1.34%
19ABIVAX SAAAVXF125,100$16.9M1.32%
20CAPRICOR THERAPEUTICS INCCAPR578,015$16.7M1.30%
21OMEROS CORPOMER950,000$16.3M1.27%
22IONIS PHARMACEUTICALS INCIONS202,038$16.0M1.25%
23FULCRUM THERAPEUTICS INCFULC1,375,472$15.6M1.21%
24ELI LILLY & COLLY13,815$14.8M1.16%
25RELMADA THERAPEUTICS INCRLMD3,068,359$14.8M1.16%
26AMGEN INCAMGN45,000$14.7M1.15%
27CYTOMX THERAPEUTICS INCCTMX3,172,616$13.5M1.06%
28PHARVARIS N VPHVS486,856$13.5M1.05%
29CONNECT BIOPHARMA HLDGS LTDCNTB4,788,486$13.5M1.05%
30BRIGHT MINDS BIOSCIENCES INCDRUG159,421$12.4M0.97%
31TENAX THERAPEUTICS INCTENX967,600$11.8M0.92%
32REVOLUTION MEDICINES INCRVMDW138,142$11.0M0.86%
33CYTOKINETICS INCCYTK172,672$11.0M0.86%
34SPRUCE BIOSCIENCES INCSPRB121,356$10.6M0.83%
35CELCUITY INCCELC105,545$10.5M0.82%
36RAPT THERAPEUTICS INC75382E208290,000$9.8M0.77%
37OMEROS CORPOMER550,000$9.4M0.74%
38ALTO NEUROSCIENCE INCANRO515,000$9.2M0.72%
39DEXCOM INCDXCM137,500$9.1M0.71%
40PTC THERAPEUTICS INCPTCT118,657$9.0M0.70%
41HARROW INCHROW183,347$9.0M0.70%
42VENTYX BIOSCIENCES INC92332V107958,704$8.7M0.68%
43CG ONCOLOGY INCCGON199,473$8.3M0.65%
44CORCEPT THERAPEUTICS INCCORT236,700$8.2M0.64%
45FORTE BIOSCIENCES INCFBRX300,000$8.2M0.64%
46APELLIS PHARMACEUTICALS INCAPLS325,600$8.2M0.64%
47PELTHOS THERAPEUTICS INCPTHS255,758$7.9M0.62%
48NEUROCRINE BIOSCIENCES INCNBIX54,062$7.7M0.60%
49REVOLUTION MEDICINES INCRVMDW95,000$7.6M0.59%
50IONIS PHARMACEUTICALS INCIONS94,600$7.5M0.58%
51MINERALYS THERAPEUTICS INCMLYS200,000$7.3M0.57%
52NEUROCRINE BIOSCIENCES INCNBIX51,000$7.2M0.56%
53ALPHA COGNITION INCACOG1,056,259$6.9M0.54%
54GALECTO INC36322Q206285,710$6.6M0.51%
55INVIVYD INCIVVD2,656,570$6.6M0.51%
56ANI PHARMACEUTICALS INCANIP82,800$6.5M0.51%
57CORCEPT THERAPEUTICS INCCORT185,593$6.5M0.50%
58NUVALENT INCNUVL59,594$6.0M0.47%
59ULTRAGENYX PHARMACEUTICAL INRARE255,100$5.9M0.46%
60ULTRAGENYX PHARMACEUTICAL INRARE250,000$5.8M0.45%
61CORCEPT THERAPEUTICS INCCORT163,800$5.7M0.45%
62LEXEO THERAPEUTICS INCLXEO513,011$5.1M0.40%
63OLEMA PHARMACEUTICALS INCOLMA200,000$5.0M0.39%
64LEGEND BIOTECH CORPLEGN226,888$4.9M0.39%
65JADE BIOSCIENCES INCJBIO300,000$4.6M0.36%
66EUPRAXIA PHARMACEUTICALS INCEPRX610,000$4.6M0.36%
67DELCATH SYS INCDCTH431,251$4.4M0.34%
68COMPASS THERAPEUTICS INCCMPX800,000$4.3M0.34%
69ADMA BIOLOGICS INCADMA234,854$4.3M0.33%
70ARVINAS INCARVN358,257$4.2M0.33%
71ZURA BIO LTDZURA802,322$4.2M0.33%
72KARYOPHARM THERAPEUTICS INCKPTI544,554$4.0M0.31%
73AGIOS PHARMACEUTICALS INCAGIO137,200$3.7M0.29%
74KRYSTAL BIOTECH INCKRYS14,814$3.7M0.29%
75TG THERAPEUTICS INCTGTX117,903$3.5M0.27%
76VIR BIOTECHNOLOGY INCVIR575,712$3.5M0.27%
77NEXTCURE INCNXTC238,303$3.4M0.26%
78ALECTOR INCALEC2,082,606$3.2M0.25%
79CONTINEUM THERAPEUTICS INCCTNM282,874$3.2M0.25%
80AQUESTIVE THERAPEUTICS INCAQST500,000$3.2M0.25%
81SOLENO THERAPEUTICS INCSLNO68,823$3.2M0.25%
82AGIOS PHARMACEUTICALS INCAGIO115,489$3.1M0.25%
83PERCEPTIVE CAP SOLUTIONS CORG70077105240,951$3.1M0.25%
84QUOIN PHARMACEUTICALS LTDQNRX211,538$3.1M0.24%
85KALARIS THERAPEUTICS INCKLRS360,000$3.0M0.24%
86PROQR THRAPEUTICS N VN715421091,492,229$3.0M0.24%
87PEPGEN INCPEPG447,165$2.9M0.23%
88COMPASS PATHWAYS PLCCMPS400,000$2.8M0.22%
89BRIDGEBIO ONCOLOGY THERAPEUTBBOT220,231$2.8M0.22%
90ERASCA INCERAS735,396$2.7M0.21%
91TARSUS PHARMACEUTICALS INCTARS31,166$2.6M0.20%
92UNIQURE NVQURE105,400$2.5M0.20%
93FRACTYL HEALTH INCGUTS1,100,000$2.4M0.19%
94BIOHAVEN LTDBHVN212,481$2.4M0.19%
95SOLID BIOSCIENCES INCSLDB424,000$2.4M0.19%
96INVENTIVA SAIVEVF502,601$2.3M0.18%
97NEUMORA THERAPEUTICS INC.NMRA1,278,408$2.3M0.18%
98CUMBERLAND PHARMACEUTICALS ICPIX555,932$2.2M0.17%
99UNIQURE NVQURE91,060$2.2M0.17%
100DBV TECHNOLOGIES S ADBVTF525,000$2.1M0.16%
101ALUMIS INCALMS211,100$2.1M0.16%
102CABALETTA BIO INCCABA900,000$2.0M0.15%
103PEPGEN INCPEPG300,000$2.0M0.15%
104JOURNEY MED CORPDERM251,436$1.9M0.15%
105IBIO INCIBIO957,062$1.8M0.14%
106APELLIS PHARMACEUTICALS INCAPLS71,747$1.8M0.14%
107SILENCE THERAPEUTICS PLCSLNCF865,784$1.7M0.14%
108ZENAS BIOPHARMA INCZBIO46,800$1.7M0.13%
109ZENAS BIOPHARMA INCZBIO46,800$1.7M0.13%
110VERASTEM INCVSTM213,865$1.7M0.13%
111INSMED INCINSM9,337$1.6M0.13%
112NEWAMSTERDAM PHARMA COMPANYNAMSW45,830$1.6M0.13%
113LIPOCINE INC NEWLPCN199,542$1.6M0.13%
114GOSSAMER BIO INCGOSS500,000$1.6M0.12%
115GOSSAMER BIO INCGOSS500,000$1.6M0.12%
116NEKTAR THERAPEUTICSNKTR36,300$1.5M0.12%
117NEKTAR THERAPEUTICSNKTR36,300$1.5M0.12%
118INSMED INCINSM8,600$1.5M0.12%
119SURROZEN INCSRZNW65,788$1.5M0.12%
120WAVE LIFE SCIENCES LTDWVE85,285$1.4M0.11%
121TRAVERE THERAPEUTICS INCTVTX36,600$1.4M0.11%
122CATALYST PHARMACEUTICALS INCCPRX57,388$1.3M0.10%
123LYELL IMMUNOPHARMA INCLYEL41,081$1.3M0.10%
124ANNEXON INCANNX230,244$1.2M0.09%
125CYBIN INCHELP132,153$1.1M0.08%
126AVALO THERAPEUTICS INCAVTX58,100$1.1M0.08%
127NEURONETICS INCSTIM701,182$967,6310.08%
128SOLID BIOSCIENCES INCSLDB160,409$904,7070.07%
129DIREXION SHS ETF TR25461H85340,822$859,7120.07%
130IO BIOTECH INCIOBT1,386,565$844,2790.07%
131MIND MEDICINE MINDMED INC60255C88558,803$787,3730.06%
132TRAWS PHARMA INCTRAW678,142$766,2990.06%
133PALISADE BIO INCPALI274,978$646,1990.05%
134KEZAR LIFE SCIENCES INCKZR102,211$642,9070.05%
135KALVISTA PHARMACEUTICALS INCKALV35,119$567,1730.04%
136AVALO THERAPEUTICS INCAVTX31,106$564,8850.04%
137ACUMEN PHARMACEUTICALS INCABOS254,312$536,5990.04%
138SANGAMO THERAPEUTICS INCSGMO1,218,671$511,8420.04%
139IMMATICS N.VIMTX48,569$509,9760.04%
140EQUILLIUM INCEQ303,555$470,5100.04%
141CONNECT BIOPHARMA HLDGS LTDCNTB144,600$407,7720.03%
142OVID THERAPEUTICS INCOVID247,558$403,5200.03%
143IMMUNIC INCIMUX674,662$360,0670.03%
144EVAXION AS29970R30374,698$356,3100.03%
145VISTAGEN THERAPEUTICS INCVTGN519,077$343,5760.03%
146VIKING THERAPEUTICS INCVKTX9,717$341,8440.03%
147STRUCTURE THERAPEUTICS INCGPCR4,824$335,5100.03%
148ULTRAGENYX PHARMACEUTICAL INRARE12,671$291,4330.02%
149VERU INCVERU133,517$285,7260.02%
150CNS PHARMACEUTICALS INCCNSP45,830$240,6080.02%
151SENSEI BIOTHERAPEUTICS INCSNSE21,351$227,8150.02%
152NYXOAH S ANYXH47,358$217,8460.02%
153VOYAGER THERAPEUTICS INCVYGR53,063$208,5380.02%
154LEXICON PHARMACEUTICALS INCLXRX164,674$189,3760.01%
155NEUPHORIA THERAPEUTICS INCNEUP47,443$184,0790.01%
156GLUCOTRACK INCGCTK45,830$177,3620.01%
157VYNE THERAPEUTICS INCVYNE264,912$153,6750.01%
158CARTESIAN THERAPEUTICS INCRNAC20,807$150,0180.01%
159SHUTTLE PHARMACTCLS HLDGS IN82569340168,993$124,1870.01%
160MACROGENICS INCMGNX74,893$120,5780.01%
161PMV PHARMACEUTICALS INCPMVP89,136$111,4210.01%
162HYPERLIQUID STRATEGIES INCPURR30,001$106,8040.01%
163MANGOCEUTICALS INCMGRX138,146$102,2290.01%
164CHEMOMAB THERAPEUTICS LTDCMMB51,793$85,4580.01%
165LYRA THERAPEUTICS INCLYRA21,161$65,1760.01%
166JASPER THERAPEUTICS INCJSPRW24,093$44,0900.00%
167AETHLON MED INCAEMD14,364$39,7880.00%
168REZOLUTE INCRZLT16,479$38,8910.00%
169BIOMX INCPHGE19,473$36,4140.00%
170AIRSCULPT TECHNOLOGIES INCAIRS16,398$32,4680.00%
171THERIVA BIOLOGICS INCTOVX112,076$23,5800.00%
172SYNLOGIC INCSYBX19,966$22,3620.00%
173ANEBULO PHARMACEUTICALS INCANEB17,736$17,9130.00%
174AUTONOMIX MED INCAMIX18,688$10,2780.00%