13F HOLDINGS REPORT
Rock Springs Capital Management LP
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001172661-26-000917
Total Value
$1.95B
Positions
99
Other Managers
0
Confidential Omitted
No
Holdings (99)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | ELI LILLY & CO | LLY | 105,400 | $113.3M | 5.81% |
| 2 | REVOLUTION MEDICINES INC | RVMDW | 1,335,270 | $106.4M | 5.45% |
| 3 | ARGENX SE | ARGX | 103,250 | $86.8M | 4.45% |
| 4 | TRAVERE THERAPEUTICS INC | TVTX | 2,210,322 | $84.5M | 4.33% |
| 5 | MADRIGAL PHARMACEUTICALS INC | MDGL | 139,618 | $81.3M | 4.17% |
| 6 | RHYTHM PHARMACEUTICALS INC | RYTM | 695,010 | $74.4M | 3.81% |
| 7 | EXACT SCIENCES CORP | 30063P105 | 601,800 | $61.1M | 3.13% |
| 8 | MIRUM PHARMACEUTICALS INC | MIRM | 762,294 | $60.2M | 3.09% |
| 9 | INSMED INC | INSM | 319,250 | $55.6M | 2.85% |
| 10 | STRUCTURE THERAPEUTICS INC | GPCR | 748,236 | $52.0M | 2.67% |
| 11 | INTUITIVE SURGICAL INC | ISRG | 82,000 | $46.4M | 2.38% |
| 12 | CIDARA THERAPEUTICS INC | 171757206 | 204,878 | $45.3M | 2.32% |
| 13 | ASCENDIS PHARMA A/S | ASND | 203,500 | $43.4M | 2.23% |
| 14 | IRHYTHM TECHNOLOGIES INC | IRTC | 235,000 | $41.7M | 2.14% |
| 15 | KYMERA THERAPEUTICS INC | KYMR | 496,871 | $38.7M | 1.98% |
| 16 | BOSTON SCIENTIFIC CORP | BSX | 399,050 | $38.0M | 1.95% |
| 17 | PENUMBRA INC | PEN | 120,500 | $37.5M | 1.92% |
| 18 | XENON PHARMACEUTICALS INC | XENE | 787,788 | $35.3M | 1.81% |
| 19 | SCHOLAR ROCK HLDG CORP | SRRK | 733,477 | $32.3M | 1.66% |
| 20 | COGENT BIOSCIENCES INC | COGT | 849,030 | $30.2M | 1.55% |
| 21 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 1,267,241 | $29.1M | 1.49% |
| 22 | VERA THERAPEUTICS INC | VERA | 568,579 | $28.8M | 1.48% |
| 23 | ALNYLAM PHARMACEUTICALS INC | ALNY | 71,250 | $28.3M | 1.45% |
| 24 | AMICUS THERAPEUTICS INC | FOLD | 1,929,931 | $27.5M | 1.41% |
| 25 | SPDR SERIES TRUST | 78464A870 | 222,000 | $27.1M | 1.39% |
| 26 | TENET HEALTHCARE CORP | THC | 125,000 | $24.8M | 1.27% |
| 27 | DEXCOM INC | DXCM | 347,300 | $23.1M | 1.18% |
| 28 | AGIOS PHARMACEUTICALS INC | AGIO | 799,163 | $21.8M | 1.12% |
| 29 | TARSUS PHARMACEUTICALS INC | TARS | 260,344 | $21.3M | 1.09% |
| 30 | COMPASS THERAPEUTICS INC | CMPX | 3,927,202 | $21.1M | 1.08% |
| 31 | NEWAMSTERDAM PHARMA COMPANY | NAMSW | 557,194 | $19.5M | 1.00% |
| 32 | AZENTA INC | AZTA | 569,100 | $18.9M | 0.97% |
| 33 | CELLDEX THERAPEUTICS INC NEW | CLDX | 692,538 | $18.8M | 0.96% |
| 34 | CARIS LIFE SCIENCES INC | CAI | 687,500 | $18.5M | 0.95% |
| 35 | ZENAS BIOPHARMA INC | ZBIO | 502,077 | $18.2M | 0.93% |
| 36 | DYNE THERAPEUTICS INC | DYN | 912,955 | $17.9M | 0.92% |
| 37 | NEUROCRINE BIOSCIENCES INC | NBIX | 125,500 | $17.8M | 0.91% |
| 38 | PHARVARIS N V | PHVS | 623,402 | $17.3M | 0.89% |
| 39 | MINERALYS THERAPEUTICS INC | MLYS | 427,596 | $15.5M | 0.80% |
| 40 | PHREESIA INC | PHR | 876,600 | $14.8M | 0.76% |
| 41 | ZAI LAB LTD | ZLAB | 811,546 | $14.3M | 0.73% |
| 42 | DANAHER CORPORATION | 235851102 | 61,500 | $14.1M | 0.72% |
| 43 | UNITEDHEALTH GROUP INC | UNH | 40,800 | $13.5M | 0.69% |
| 44 | ARDELYX INC | ARDX | 2,299,473 | $13.4M | 0.69% |
| 45 | ACLARIS THERAPEUTICS INC | ACRS | 4,453,741 | $13.4M | 0.69% |
| 46 | SUMMIT THERAPEUTICS INC | SMMT | 710,000 | $12.4M | 0.64% |
| 47 | ENLIVEN THERAPEUTICS INC | ELVN | 798,405 | $12.3M | 0.63% |
| 48 | INSPIRE MED SYS INC | 457730109 | 131,000 | $12.1M | 0.62% |
| 49 | OMADA HEALTH INC | OMDA | 740,000 | $11.7M | 0.60% |
| 50 | SOLENO THERAPEUTICS INC | SLNO | 247,053 | $11.4M | 0.59% |
| 51 | ARCELLX INC | ACLX | 169,859 | $11.1M | 0.57% |
| 52 | EVOLENT HEALTH INC | EVH | 2,675,000 | $10.7M | 0.55% |
| 53 | GOSSAMER BIO INC | GOSS | 3,266,960 | $10.1M | 0.52% |
| 54 | MBX BIOSCIENCES INC | MBX | 282,624 | $8.9M | 0.46% |
| 55 | CENTESSA PHARMACEUTICALS PLC | CNTA | 324,015 | $8.1M | 0.42% |
| 56 | HEARTFLOW INC | HTFL | 277,700 | $8.1M | 0.42% |
| 57 | BRIDGEBIO PHARMA INC | BBIO | 103,500 | $7.9M | 0.41% |
| 58 | REGENERON PHARMACEUTICALS | REGN | 10,100 | $7.8M | 0.40% |
| 59 | IMMUNOME INC | IMNM | 347,666 | $7.5M | 0.38% |
| 60 | RAPT THERAPEUTICS INC | 75382E208 | 213,731 | $7.2M | 0.37% |
| 61 | BICARA THERAPEUTICS INC | BCAX | 429,095 | $7.2M | 0.37% |
| 62 | EDWARDS LIFESCIENCES CORP | EW | 82,500 | $7.0M | 0.36% |
| 63 | GOSSAMER BIO INC | GOSS | 9,573,000 | $6.6M | 0.34% |
| 64 | ALPHATEC HLDGS INC | ATEC | 302,500 | $6.4M | 0.33% |
| 65 | AMYLYX PHARMACEUTICALS INC | AMLX | 499,764 | $6.0M | 0.31% |
| 66 | THERMO FISHER SCIENTIFIC INC | TMO | 10,000 | $5.8M | 0.30% |
| 67 | JANUX THERAPEUTICS INC | JANX | 358,798 | $5.0M | 0.25% |
| 68 | SURGERY PARTNERS INC | SGRY | 310,000 | $4.8M | 0.25% |
| 69 | EYEPOINT INC | EYPT | 258,739 | $4.7M | 0.24% |
| 70 | PTC THERAPEUTICS INC | PTCT | 61,879 | $4.7M | 0.24% |
| 71 | AGILON HEALTH INC | AGL | 6,500,000 | $4.5M | 0.23% |
| 72 | MERSANA THERAPEUTICS INC | 59045L205 | 152,586 | $4.4M | 0.23% |
| 73 | TERNS PHARMACEUTICALS INC | TERN | 108,481 | $4.4M | 0.22% |
| 74 | ARCUS BIOSCIENCES INC | RCUS | 180,000 | $4.3M | 0.22% |
| 75 | EDAP TMS S A | EDAP | 1,286,500 | $4.2M | 0.22% |
| 76 | OCULAR THERAPEUTIX INC | OCUL | 345,820 | $4.2M | 0.22% |
| 77 | LENZ THERAPEUTICS INC | LENZ | 257,460 | $4.1M | 0.21% |
| 78 | TALPHERA INC | TLPH | 3,589,186 | $4.1M | 0.21% |
| 79 | SIONNA THERAPEUTICS INC | SION | 99,429 | $4.1M | 0.21% |
| 80 | THERAVANCE BIOPHARMA INC | TBPH | 208,771 | $3.9M | 0.20% |
| 81 | ALKERMES PLC | ALKS | 139,228 | $3.9M | 0.20% |
| 82 | APELLIS PHARMACEUTICALS INC | APLS | 150,500 | $3.8M | 0.19% |
| 83 | INDIVIOR PLC | INDV | 105,100 | $3.8M | 0.19% |
| 84 | ERASCA INC | ERAS | 951,710 | $3.5M | 0.18% |
| 85 | TANGO THERAPEUTICS INC | TNGX | 386,915 | $3.4M | 0.18% |
| 86 | OLEMA PHARMACEUTICALS INC | OLMA | 98,240 | $2.5M | 0.13% |
| 87 | CYTOKINETICS INC | CYTK | 35,853 | $2.3M | 0.12% |
| 88 | VAXCYTE INC | PCVX | 47,000 | $2.2M | 0.11% |
| 89 | NEUROGENE INC | NGNE | 104,339 | $2.1M | 0.11% |
| 90 | JASPER THERAPEUTICS INC | JSPRW | 1,100,726 | $2.0M | 0.10% |
| 91 | ROIVANT SCIENCES LTD | ROIV | 88,750 | $1.9M | 0.10% |
| 92 | CORCEPT THERAPEUTICS INC | CORT | 50,250 | $1.7M | 0.09% |
| 93 | ACADIA HEALTHCARE COMPANY IN | ACHC | 120,000 | $1.7M | 0.09% |
| 94 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 45,500 | $1.4M | 0.07% |
| 95 | NEWAMSTERDAM PHARMA COMPANY | NAMSW | 31,600 | $1.1M | 0.06% |
| 96 | MOONLAKE IMMUNOTHERAPEUTICS | MLTX | 61,700 | $813,206 | 0.04% |
| 97 | LEGEND BIOTECH CORP | LEGN | 33,800 | $734,812 | 0.04% |
| 98 | JAZZ PHARMACEUTICALS PLC | JAZZ | 1,750 | $297,500 | 0.02% |
| 99 | NUVATION BIO INC | NUVB | 134,028 | $44,229 | 0.00% |