13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q1 2025 · Filed May 15, 2025 · Accession 0001104659-25-049518
Total Value
$9.04B
Positions
89
Other Managers
0
Confidential Omitted
No
Holdings (89)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | BeiGene, Ltd. | BEIGF | 8,799,053 | $2.39B | 26.50% |
| 2 | Incyte Corporation | INCY | 30,739,953 | $1.86B | 20.60% |
| 3 | ACADIA Pharmaceuticals Inc. | ACAD | 42,877,916 | $712.2M | 7.88% |
| 4 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,974,590 | $654.0M | 7.24% |
| 5 | Summit Therapeutics Inc. | SMMT | 24,424,865 | $471.2M | 5.21% |
| 6 | Insmed Incorporated | INSM | 5,380,626 | $410.5M | 4.54% |
| 7 | Rhythm Pharmaceuticals, Inc. | RYTM | 5,604,483 | $296.9M | 3.29% |
| 8 | Revolution Medicines, Inc. | RVMDW | 7,936,972 | $280.7M | 3.11% |
| 9 | Kymera Therapeutics, Inc. | KYMR | 5,995,929 | $164.1M | 1.82% |
| 10 | Alkermes plc | ALKS | 4,483,285 | $148.0M | 1.64% |
| 11 | Edgewise Therapeutics, Inc. | EWTX | 6,155,940 | $135.4M | 1.50% |
| 12 | Replimune Group, Inc. | REPL | 11,045,336 | $107.7M | 1.19% |
| 13 | Insmed Incorporated | INSM | 42,850,000 | $101.6M | 1.12% |
| 14 | Immunovant, Inc. | IMVT | 5,457,881 | $93.3M | 1.03% |
| 15 | Bicycle Therapeutics plc | BCYC | 10,885,357 | $92.4M | 1.02% |
| 16 | Immunocore Holdings plc | IMCR | 2,322,656 | $68.9M | 0.76% |
| 17 | Kiniksa Pharmaceuticals International, plc | G52694109 | 2,818,323 | $62.6M | 0.69% |
| 18 | AbCellera Biologics Inc. | ABCL | 27,525,640 | $61.4M | 0.68% |
| 19 | Ultragenyx Pharmaceutical Inc. | RARE | 1,576,114 | $57.1M | 0.63% |
| 20 | Denali Therapeutics Inc. | DNLI | 3,731,695 | $50.7M | 0.56% |
| 21 | Kodiak Sciences Inc. | KOD | 17,310,490 | $48.6M | 0.54% |
| 22 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $46.1M | 0.51% |
| 23 | argenx SE | ARGX | 77,760 | $46.0M | 0.51% |
| 24 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $44.0M | 0.49% |
| 25 | Celcuity Inc. | CELC | 4,257,735 | $43.0M | 0.48% |
| 26 | GRAIL, Inc. | GRAL | 1,630,125 | $41.6M | 0.46% |
| 27 | Roivant Sciences Ltd. | ROIV | 3,767,773 | $38.0M | 0.42% |
| 28 | Immatics N.V. | IMTX | 7,275,830 | $32.8M | 0.36% |
| 29 | Stoke Therapeutics, Inc. | STOK | 4,633,838 | $30.8M | 0.34% |
| 30 | Cerus Corporation | CERS | 19,351,087 | $26.9M | 0.30% |
| 31 | Vaxcyte, Inc. | PCVX | 640,885 | $24.2M | 0.27% |
| 32 | Monte Rosa Therapeutics, Inc. | GLUE | 4,916,095 | $22.8M | 0.25% |
| 33 | CRISPR Therapeutics AG | CRSP | 654,099 | $22.3M | 0.25% |
| 34 | Akero Therapeutics, Inc. | 00973Y108 | 548,713 | $22.2M | 0.25% |
| 35 | Sera Prognostics, Inc. | SERA | 5,498,170 | $20.2M | 0.22% |
| 36 | Centessa Pharmaceuticals plc | CNTA | 1,227,178 | $17.6M | 0.20% |
| 37 | Neurogene Inc. | NGNE | 1,486,200 | $17.4M | 0.19% |
| 38 | IDEAYA Biosciences, Inc. | IDYA | 1,062,123 | $17.4M | 0.19% |
| 39 | Verona Pharma plc | 925050106 | 223,843 | $14.2M | 0.16% |
| 40 | Candel Therapeutics, Inc. | CADL | 2,437,189 | $13.8M | 0.15% |
| 41 | Praxis Precision Medicines, Inc. | PRAX | 331,533 | $12.6M | 0.14% |
| 42 | 2seventy bio, Inc. | 901384107 | 2,497,526 | $12.3M | 0.14% |
| 43 | Xenon Pharmaceuticals Inc. | XENE | 347,408 | $11.7M | 0.13% |
| 44 | Bicara Therapeutics Inc. | BCAX | 833,333 | $10.9M | 0.12% |
| 45 | Ionis Pharmaceuticals, Inc. | IONS | 357,915 | $10.8M | 0.12% |
| 46 | DBV Technologies S.A. | DBVTF | 1,461,425 | $10.0M | 0.11% |
| 47 | Alumis Inc. | ALMS | 1,562,500 | $9.6M | 0.11% |
| 48 | Merus N.V. | N5749R100 | 223,500 | $9.4M | 0.10% |
| 49 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $7.8M | 0.09% |
| 50 | Verve Therapeutics, Inc. | 92539P101 | 1,691,530 | $7.7M | 0.09% |
| 51 | Rocket Pharmaceuticals, Inc. | RCKTW | 1,097,079 | $7.3M | 0.08% |
| 52 | Xencor, Inc. | XNCR | 670,431 | $7.1M | 0.08% |
| 53 | Dyne Therapeutics, Inc. | DYN | 672,096 | $7.0M | 0.08% |
| 54 | KALA BIO, Inc. | KALA | 1,201,894 | $6.9M | 0.08% |
| 55 | Design Therapeutics, Inc. | DSGN | 1,743,725 | $6.7M | 0.07% |
| 56 | Structure Therapeutics Inc. | GPCR | 361,565 | $6.3M | 0.07% |
| 57 | Taysha Gene Therapies, Inc. | TSHA | 4,004,756 | $5.6M | 0.06% |
| 58 | Regulus Therapeutics Inc. | 75915K309 | 2,694,044 | $4.7M | 0.05% |
| 59 | IGM Biosciences, Inc. | 449585108 | 4,095,257 | $4.7M | 0.05% |
| 60 | Intellia Therapeutics, Inc. | NTLA | 644,116 | $4.6M | 0.05% |
| 61 | Celldex Therapeutics, Inc. | CLDX | 247,644 | $4.5M | 0.05% |
| 62 | Sionna Therapeutics, Inc. | SION | 400,000 | $4.2M | 0.05% |
| 63 | BioNTech SE | BNTX | 45,031 | $4.1M | 0.05% |
| 64 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $3.8M | 0.04% |
| 65 | Disc Medicine, Inc. | IRON | 77,050 | $3.8M | 0.04% |
| 66 | Vir Biotechnology, Inc. | VIR | 542,539 | $3.5M | 0.04% |
| 67 | Sana Biotechnology, Inc. | SANA | 2,030,949 | $3.4M | 0.04% |
| 68 | Sagimet Biosciences Inc. | SGMT | 952,996 | $3.1M | 0.03% |
| 69 | Relay Therapeutics, Inc. | RLAY | 1,160,117 | $3.0M | 0.03% |
| 70 | Wave Life Sciences Ltd. | WVE | 344,063 | $2.8M | 0.03% |
| 71 | Fate Therapeutics, Inc. | FATE | 3,258,402 | $2.6M | 0.03% |
| 72 | Skye Bioscience, Inc. | SKYE | 1,450,638 | $2.3M | 0.03% |
| 73 | Protara Therapeutics, Inc. | TARA | 536,832 | $2.3M | 0.03% |
| 74 | Enliven Therapeutics, Inc. | ELVN | 114,833 | $2.3M | 0.03% |
| 75 | Contineum Therapeutics, Inc. | CTNM | 312,500 | $2.2M | 0.02% |
| 76 | Prime Medicine, Inc. | PRME | 1,028,466 | $2.0M | 0.02% |
| 77 | Tectonic Therapeutic, Inc. | TECX | 100,000 | $1.8M | 0.02% |
| 78 | vTv Therapeutics, Inc. | VTVT | 97,314 | $1.7M | 0.02% |
| 79 | Compass Therapeutics, Inc. | CMPX | 547,498 | $1.0M | 0.01% |
| 80 | Neumora Therapeutics, Inc. | NMRA | 1,034,600 | $1.0M | 0.01% |
| 81 | HOOKIPA Pharma Inc. | HOOK | 812,814 | $877,839 | 0.01% |
| 82 | Generation Bio Co. | 37148K100 | 1,944,945 | $787,703 | 0.01% |
| 83 | Aligos Therapeutics, Inc. | ALGS | 83,055 | $685,204 | 0.01% |
| 84 | Leap Therapeutics, Inc. | CYPH | 404,744 | $123,487 | 0.00% |
| 85 | Century Therapeutics, Inc. | IPSC | 241,684 | $115,042 | 0.00% |
| 86 | Tyra Biosciences, Inc. | TYRA | 10,607 | $98,645 | 0.00% |
| 87 | Acrivon Therapeutics, Inc. | ACRV | 22,809 | $46,302 | 0.00% |
| 88 | Surrozen, Inc. | SRZNW | 833,333 | $25,000 | 0.00% |
| 89 | Opthea Limited | OPTEY | 2,087,320 | $0 | 0.00% |