New Positions
12 managers initiated
Top five by reported value
- Anson Funds Management LP$739.3K
- Nantahala Capital Management, LLC$580.1K
- T3 Companies, LLC$548.2K
- KVP Capital Advisors, LP$290.4K
- ADAR1 Capital Management, LLC$147.2K
Vyne Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:VYNE
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
12 new10 added20 reduced3 exited
Total Institutional Holders
42
as of 2025-12-31
Top Holder
Shay Capital LLC
$942.3K
Largest QoQ Increase
Anson Funds Management LP
+1,274,386 sh
Largest QoQ Decrease
BAKER BROS. ADVISORS LP
-851,353 sh
New Positions(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Anson Funds Management LP | 1,274,386 | +1,274,386 | $739.3K | +$739.3K | — |
| Nantahala Capital Management, LLC | 1,000,000 | +1,000,000 | $580.1K | +$580.1K | — |
| T3 Companies, LLC | 945,000 | +945,000 | $548.2K | +$548.2K | — |
| KVP Capital Advisors, LP | 500,551 | +500,551 | $290.4K | +$290.4K | — |
| ADAR1 Capital Management, LLC | 253,791 | +253,791 | $147.2K | +$147.2K | — |
| XTX Topco Ltd | 79,040 | +79,040 | $45.9K | +$45.9K | — |
| CITADEL ADVISORS LLC | 30,526 | +30,526 | $17.7K | +$17.7K | — |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 800 | +800 | $464 | +$464 | — |
| Hurley Capital, LLC | 561 | +561 | $325 | +$325 | — |
| Virtu Financial LLC | 25,327 | +25,327 | $15 | +$15 | — |
| FNY Investment Advisers, LLC | 25,000 | +25,000 | $14 | +$14 | — |
| Motiv8 Investments LLC | 1 | +1 | $0 | $0 | — |
Added To(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Shay Capital LLC | 1,624,349 | +1,131,772 | $942.3K | +$777.3K | 229.8% |
| VANGUARD GROUP INC | 314,545 | +124,162 | $182.4K | +$118.7K | 65.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 225,152 | +88,030 | $130.6K | +$84.7K | 64.2% |
| TWO SIGMA ADVISERS, LP | 163,100 | +106,500 | $94.6K | +$75.7K | 188.2% |
| Rangeley Capital, LLC | 100,000 | +50,000 | $58.0K | +$41.3K | 100.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 100,341 | +42,578 | $58.2K | +$38.9K | 73.7% |
| UBS Group AG | 62,761 | +57,189 | $36.4K | +$34.5K | 1026.4% |
| BANK OF AMERICA CORP /DE/ | 1,677 | +145 | $973 | +$460 | 9.5% |
| ACADIAN ASSET MANAGEMENT LLC | 638,492 | +192,078 | $370 | +$222 | 43.0% |
| GSA CAPITAL PARTNERS LLP | 53,961 | +18,040 | $31 | +$19 | 50.2% |
Reduced(20)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ACORN CAPITAL ADVISORS, LLC | 1,425 | -585,147 | $827 | -$198.6K | -99.8% |
| Ikarian Capital, LLC | 264,912 | -25,088 | $153.7K | +$56.5K | -8.7% |
| TWO SIGMA INVESTMENTS, LP | 220,000 | -788 | $127.6K | +$53.7K | -0.3% |
| BOOTHBAY FUND MANAGEMENT, LLC | 81,371 | -25,088 | $47.2K | +$11.5K | -23.6% |
| BlackRock, Inc. | 44,405 | 0 | $25.8K | +$10.9K | 0.0% |
| COMMONWEALTH EQUITY SERVICES, LLC | 18,298 | 0 | $10.6K | +$10.6K | 0.0% |
| JANE STREET GROUP, LLC | 72,356 | -74,764 | $42.0K | -$7.3K | -50.8% |
| Royal Bank of Canada | 2,441 | -2,439 | $1.0K | -$7.0K | -50.0% |
| NORTHERN TRUST CORP | 23,110 | 0 | $13.4K | +$5.7K | 0.0% |
| STATE STREET CORP | 15,765 | 0 | $9.1K | +$3.9K | 0.0% |
| Harvest Investment Services, LLC | 11,059 | 0 | $6.4K | +$2.7K | 0.0% |
| Tower Research Capital LLC (TRC) | 3,567 | -30 | $2.1K | +$864 | -0.8% |
| MORGAN STANLEY | 43 | -868 | $25 | -$280 | -95.3% |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 0 | $604 | +$255 | 0.0% |
| JPMORGAN CHASE & CO | 146 | 0 | $85 | +$36 | 0.0% |
| WELLS FARGO & COMPANY/MN | 65 | 0 | $38 | +$16 | 0.0% |
| Truvestments Capital LLC | 25 | 0 | $15 | +$7 | 0.0% |
| Newbridge Financial Services Group, Inc. | 10 | 0 | $6 | +$3 | 0.0% |
| Centerpoint Advisors, LLC | 350 | 0 | $0 | $0 | 0.0% |
| CWM, LLC | 500 | 0 | $0 | $0 | 0.0% |
Sold Out(3)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 0 | -851,353 | $0 | -$285.2K | — |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | -76,958 | $0 | -$25.8K | — |
| CORSAIR CAPITAL MANAGEMENT, L.P. | 0 | -50,000 | $0 | -$16.8K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Shay Capital LLC | 1,624,349 | $942.3K | +1,131,772 | 229.8% |
| Anson Funds Management LP | 1,274,386 | $739.3K | +1,274,386 | — |
| Nantahala Capital Management, LLC | 1,000,000 | $580.1K | +1,000,000 | — |
| T3 Companies, LLC | 945,000 | $548.2K | +945,000 | — |
| KVP Capital Advisors, LP | 500,551 | $290.4K | +500,551 | — |
| VANGUARD GROUP INC | 314,545 | $182.4K | +124,162 | 65.2% |
| Ikarian Capital, LLC | 264,912 | $153.7K | -25,088 | -8.7% |
| ADAR1 Capital Management, LLC | 253,791 | $147.2K | +253,791 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 225,152 | $130.6K | +88,030 | 64.2% |
| TWO SIGMA INVESTMENTS, LP | 220,000 | $127.6K | -788 | -0.3% |
| TWO SIGMA ADVISERS, LP | 163,100 | $94.6K | +106,500 | 188.2% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 100,341 | $58.2K | +42,578 | 73.7% |
| Rangeley Capital, LLC | 100,000 | $58.0K | +50,000 | 100.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 81,371 | $47.2K | -25,088 | -23.6% |
| XTX Topco Ltd | 79,040 | $45.9K | +79,040 | — |
| JANE STREET GROUP, LLC | 72,356 | $42.0K | -74,764 | -50.8% |
| UBS Group AG | 62,761 | $36.4K | +57,189 | 1026.4% |
| BlackRock, Inc. | 44,405 | $25.8K | 0 | 0.0% |
| CITADEL ADVISORS LLC | 30,526 | $17.7K | +30,526 | — |
| NORTHERN TRUST CORP | 23,110 | $13.4K | 0 | 0.0% |
New & Closed Positions this quarter
Closed Positions
3 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for VYNE against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.