New Positions
5 managers initiated
Top five by reported value
Synlogic Inc NASDAQ NMS - GLOBAL MARKET:SYBX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
5 new6 added14 reduced3 exited
Total Institutional Holders
25
as of 2025-12-31
Top Holder
Cable Car Capital, LP
$3.7M
Largest QoQ Increase
CITADEL ADVISORS LLC
+112,597 sh
Largest QoQ Decrease
Ikarian Capital, LLC
-456 sh
New Positions(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DRW Securities, LLC | 24,363 | +24,363 | $27.3K | +$27.3K | — |
| JANE STREET GROUP, LLC | 14,998 | +14,998 | $16.8K | +$16.8K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,623 | +11,623 | $13.0K | +$13.0K | — |
| UBS Group AG | 2,531 | +2,531 | $2.8K | +$2.8K | — |
| FLAGSHIP HARBOR ADVISORS, LLC | 1,033 | +1,033 | $1.2K | +$1.2K | — |
Added To(6)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 141,608 | +112,597 | $158.6K | +$109.6K | 388.1% |
| VANGUARD GROUP INC | 201,060 | +4,599 | $225.2K | -$106.8K | 2.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 71,645 | +3,980 | $80.2K | -$34.1K | 5.9% |
| RENAISSANCE TECHNOLOGIES LLC | 85,627 | +46,117 | $95.9K | +$30.0K | 116.7% |
| XTX Topco Ltd | 14,398 | +3,225 | $16.1K | -$2.8K | 28.9% |
| BANK OF AMERICA CORP /DE/ | 66 | +2 | $73 | -$34 | 3.1% |
Reduced(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Cable Car Capital, LP | 3,312,219 | 0 | $3.7M | -$1.8M | 0.0% |
| NEA Management Company, LLC | 2,922,772 | 0 | $3.3M | -$1.6M | 0.0% |
| Ikarian Capital, LLC | 19,966 | -456 | $22.4K | -$12.2K | -2.2% |
| BlackRock, Inc. | 19,757 | 0 | $22.1K | -$10.8K | 0.0% |
| NORTHERN TRUST CORP | 19,469 | 0 | $21.8K | -$10.7K | 0.0% |
| STATE STREET CORP | 10,176 | 0 | $11.4K | -$5.8K | 0.0% |
| FMR LLC | 5,323 | 0 | $6.0K | -$3.0K | 0.0% |
| MORGAN STANLEY | 1,095 | 0 | $1.2K | -$600 | 0.0% |
| SBI Securities Co., Ltd. | 103 | 0 | $115 | -$57 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 24 | 0 | $27 | -$13 | 0.0% |
| Hilltop National Bank | 20 | 0 | $22 | -$11 | 0.0% |
| CITIGROUP INC | 1 | 0 | $1 | -$1 | 0.0% |
| JPMORGAN CHASE & CO | 1 | 0 | $1 | -$1 | 0.0% |
| DANSKE BANK A/S | 1 | 0 | $1 | -$1 | 0.0% |
Sold Out(3)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JONES FINANCIAL COMPANIES LLLP | 0 | -20 | $0 | -$35 | — |
| WELLS FARGO & COMPANY/MN | 0 | -5 | $0 | -$8 | — |
| BARCLAYS PLC | 0 | -1 | $0 | -$2 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Cable Car Capital, LP | 3,312,219 | $3.7M | 0 | 0.0% |
| NEA Management Company, LLC | 2,922,772 | $3.3M | 0 | 0.0% |
| VANGUARD GROUP INC | 201,060 | $225.2K | +4,599 | 2.3% |
| CITADEL ADVISORS LLC | 141,608 | $158.6K | +112,597 | 388.1% |
| RENAISSANCE TECHNOLOGIES LLC | 85,627 | $95.9K | +46,117 | 116.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 71,645 | $80.2K | +3,980 | 5.9% |
| DRW Securities, LLC | 24,363 | $27.3K | +24,363 | — |
| Ikarian Capital, LLC | 19,966 | $22.4K | -456 | -2.2% |
| BlackRock, Inc. | 19,757 | $22.1K | 0 | 0.0% |
| NORTHERN TRUST CORP | 19,469 | $21.8K | 0 | 0.0% |
| JANE STREET GROUP, LLC | 14,998 | $16.8K | +14,998 | — |
| XTX Topco Ltd | 14,398 | $16.1K | +3,225 | 28.9% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,623 | $13.0K | +11,623 | — |
| STATE STREET CORP | 10,176 | $11.4K | 0 | 0.0% |
| FMR LLC | 5,323 | $6.0K | 0 | 0.0% |
| UBS Group AG | 2,531 | $2.8K | +2,531 | — |
| MORGAN STANLEY | 1,095 | $1.2K | 0 | 0.0% |
| FLAGSHIP HARBOR ADVISORS, LLC | 1,033 | $1.2K | +1,033 | — |
| SBI Securities Co., Ltd. | 103 | $115 | 0 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 66 | $73 | +2 | 3.1% |
New & Closed Positions this quarter
Closed Positions
3 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for SYBX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.