New Positions
7 managers initiated
Top five by reported value
OS Therapies Inc NYSE MKT LLC:OSTX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
7 new8 added10 reduced7 exited
Total Institutional Holders
25
as of 2025-12-31
Top Holder
VANGUARD GROUP INC
$756.6K
Largest QoQ Increase
VANGUARD GROUP INC
+352,158 sh
Largest QoQ Decrease
MARSHALL WACE, LLP
-88,603 sh
New Positions(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANE STREET GROUP, LLC | 27,740 | +27,740 | $38.8K | +$38.8K | — |
| Stratos Wealth Advisors, LLC | 13,817 | +13,817 | $19.3K | +$19.3K | — |
| LPL Financial LLC | 10,113 | +10,113 | $14.2K | +$14.2K | — |
| Royal Bank of Canada | 480 | +480 | $1.0K | +$1.0K | — |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 25 | +25 | $35 | +$35 | — |
| BANK OF AMERICA CORP /DE/ | 23 | +23 | $32 | +$32 | — |
| FNY Investment Advisers, LLC | 100 | +100 | $0 | $0 | — |
Added To(8)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 540,421 | +352,158 | $756.6K | +$387.6K | 187.1% |
| TWO SIGMA INVESTMENTS, LP | 87,537 | +1,290 | $122.6K | -$46.5K | 1.5% |
| UBS Group AG | 18,156 | +17,929 | $25.4K | +$25.0K | 7898.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 246,038 | +58,350 | $344.5K | -$23.4K | 31.1% |
| STATE STREET CORP | 58,500 | +8,200 | $81.9K | -$16.7K | 16.3% |
| NORTHERN TRUST CORP | 71,309 | +15,046 | $99.8K | -$10.4K | 26.7% |
| BlackRock, Inc. | 61,425 | +13,262 | $86.0K | -$8.4K | 27.5% |
| JONES FINANCIAL COMPANIES LLLP | 10,867 | +3,000 | $15.2K | -$913 | 38.1% |
Reduced(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 109,949 | -88,603 | $153.9K | -$235.2K | -44.6% |
| CM Management, LLC | 400,000 | 0 | $560.0K | -$224.0K | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 30,785 | -62,789 | $43.1K | -$140.3K | -67.1% |
| MERCER GLOBAL ADVISORS INC /ADV | 10,220 | -10,220 | $14.3K | -$25.8K | -50.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 0 | $35.0K | -$14.0K | 0.0% |
| STIFEL FINANCIAL CORP | 15,000 | 0 | $21.0K | -$8.4K | 0.0% |
| Tower Research Capital LLC (TRC) | 88 | -4,079 | $123 | -$8.0K | -97.9% |
| MORGAN STANLEY | 1,000 | 0 | $1.4K | -$560 | 0.0% |
| ARMSTRONG ADVISORY GROUP, INC | 100 | 0 | $140 | -$56 | 0.0% |
| INGALLS & SNYDER LLC | 36,676 | 0 | $51 | -$21 | 0.0% |
Sold Out(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Ground Swell Capital, LLC | 0 | -20,462 | $0 | -$40.1K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | -14,961 | $0 | -$29.3K | — |
| SANDERS MORRIS HARRIS LLC | 0 | -12,000 | $0 | -$23.5K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -10,237 | $0 | -$20.1K | — |
| Full Sail Capital, LLC | 0 | -10,220 | $0 | -$20.0K | — |
| Virtu Financial LLC | 0 | -75,801 | $0 | -$149 | — |
| JPMORGAN CHASE & CO | 0 | -13 | $0 | -$25 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| VANGUARD GROUP INC | 540,421 | $756.6K | +352,158 | 187.1% |
| CM Management, LLC | 400,000 | $560.0K | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 246,038 | $344.5K | +58,350 | 31.1% |
| MARSHALL WACE, LLP | 109,949 | $153.9K | -88,603 | -44.6% |
| TWO SIGMA INVESTMENTS, LP | 87,537 | $122.6K | +1,290 | 1.5% |
| NORTHERN TRUST CORP | 71,309 | $99.8K | +15,046 | 26.7% |
| BlackRock, Inc. | 61,425 | $86.0K | +13,262 | 27.5% |
| STATE STREET CORP | 58,500 | $81.9K | +8,200 | 16.3% |
| MILLENNIUM MANAGEMENT LLC | 30,785 | $43.1K | -62,789 | -67.1% |
| JANE STREET GROUP, LLC | 27,740 | $38.8K | +27,740 | — |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | $35.0K | 0 | 0.0% |
| UBS Group AG | 18,156 | $25.4K | +17,929 | 7898.2% |
| STIFEL FINANCIAL CORP | 15,000 | $21.0K | 0 | 0.0% |
| Stratos Wealth Advisors, LLC | 13,817 | $19.3K | +13,817 | — |
| JONES FINANCIAL COMPANIES LLLP | 10,867 | $15.2K | +3,000 | 38.1% |
| MERCER GLOBAL ADVISORS INC /ADV | 10,220 | $14.3K | -10,220 | -50.0% |
| LPL Financial LLC | 10,113 | $14.2K | +10,113 | — |
| MORGAN STANLEY | 1,000 | $1.4K | 0 | 0.0% |
| Royal Bank of Canada | 480 | $1.0K | +480 | — |
| ARMSTRONG ADVISORY GROUP, INC | 100 | $140 | 0 | 0.0% |
New & Closed Positions this quarter
Closed Positions
7 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for OSTX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.