New Positions
21 managers initiated
Top five by reported value
- Potomac Capital Management, Inc.$3.3M
- Cresset Asset Management, LLC$515.2K
- LPL Financial LLC$343.1K
- Focus Partners Wealth$250.7K
- SIMPLEX TRADING, LLC$154.4K
Gain Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:GANX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
21 new15 added12 reduced10 exited
Total Institutional Holders
48
as of 2025-12-31
Top Holder
MARSHALL WACE, LLP
$5.4M
Largest QoQ Increase
MARSHALL WACE, LLP
+1,487,186 sh
Largest QoQ Decrease
CITADEL ADVISORS LLC
-306,358 sh
New Positions(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Potomac Capital Management, Inc. | 1,010,000 | +1,010,000 | $3.3M | +$3.3M | — |
| Cresset Asset Management, LLC | 160,000 | +160,000 | $515.2K | +$515.2K | — |
| LPL Financial LLC | 106,550 | +106,550 | $343.1K | +$343.1K | — |
| Focus Partners Wealth | 77,855 | +77,855 | $250.7K | +$250.7K | — |
| SIMPLEX TRADING, LLC | 47,946 | +47,946 | $154.4K | +$154.4K | — |
| OMERS ADMINISTRATION Corp | 37,300 | +37,300 | $120.1K | +$120.1K | — |
| GOLDMAN SACHS GROUP INC | 32,494 | +32,494 | $104.6K | +$104.6K | — |
| Point72 Asset Management, L.P. | 32,480 | +32,480 | $104.6K | +$104.6K | — |
| Lighthouse Investment Partners, LLC | 23,040 | +23,040 | $74.2K | +$74.2K | — |
| Oliver Luxxe Assets LLC | 20,250 | +20,250 | $65.2K | +$65.2K | — |
| Apollon Wealth Management, LLC | 19,825 | +19,825 | $63.8K | +$63.8K | — |
| Wealthspire Advisors, LLC | 16,900 | +16,900 | $54.4K | +$54.4K | — |
| Engineers Gate Manager LP | 14,617 | +14,617 | $47.1K | +$47.1K | — |
| MILLENNIUM MANAGEMENT LLC | 14,002 | +14,002 | $45.1K | +$45.1K | — |
| COMMONWEALTH EQUITY SERVICES, LLC | 12,685 | +12,685 | $40.9K | +$40.9K | — |
| SPROTT INC. | 12,000 | +12,000 | $38.6K | +$38.6K | — |
| BNP PARIBAS ARBITRAGE, SNC | 2,381 | +2,381 | $7.7K | +$7.7K | — |
| State of Wyoming | 1,438 | +1,438 | $4.6K | +$4.6K | — |
| GSA CAPITAL PARTNERS LLP | 20,472 | +20,472 | $66 | +$66 | — |
| Larson Financial Group LLC | 10 | +10 | $32 | +$32 | — |
| FNY Investment Advisers, LLC | 2,000 | +2,000 | $6 | +$6 | — |
Added To(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 1,662,293 | +1,487,186 | $5.4M | +$5.0M | 849.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 728,949 | +648,514 | $2.3M | +$2.2M | 806.3% |
| JONES FINANCIAL COMPANIES LLLP | 702,213 | +25,391 | $2.3M | +$1.0M | 3.8% |
| VANGUARD GROUP INC | 569,901 | +35,549 | $1.8M | +$889.3K | 6.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 397,942 | +53,796 | $1.3M | +$673.3K | 15.6% |
| JANE STREET GROUP, LLC | 242,328 | +169,878 | $780.3K | +$652.1K | 234.5% |
| BlackRock, Inc. | 209,579 | +93,395 | $674.8K | +$469.2K | 80.4% |
| STATE STREET CORP | 157,537 | +66,400 | $507.3K | +$346.0K | 72.8% |
| NORTHERN TRUST CORP | 102,001 | +13,602 | $328.4K | +$172.0K | 15.4% |
| GROUP ONE TRADING, L.P. | 54,159 | +37,384 | $174.4K | +$144.7K | 222.8% |
| BENEDICT FINANCIAL ADVISORS INC | 38,000 | +3,000 | $122.4K | +$60.4K | 8.6% |
| Tower Research Capital LLC (TRC) | 6,859 | +4,795 | $22.1K | +$18.4K | 232.3% |
| BANK OF AMERICA CORP /DE/ | 3,908 | +1 | $12.6K | +$5.7K | 0.0% |
| Cambridge Investment Research Advisors, Inc. | 568,645 | +250,000 | $1.8K | +$1.3K | 78.5% |
| HRT FINANCIAL LP | 55,679 | +35,962 | $179 | +$145 | 182.4% |
Reduced(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DME Capital Management, LP | 566,130 | 0 | $1.8M | +$820.9K | 0.0% |
| CITADEL ADVISORS LLC | 77,500 | -306,358 | $249.6K | -$429.9K | -79.8% |
| MORGAN STANLEY | 147,591 | -8,084 | $475.2K | +$199.7K | -5.2% |
| RENAISSANCE TECHNOLOGIES LLC | 17,400 | -108,700 | $56.0K | -$167.2K | -86.2% |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35,820 | 0 | $115.3K | +$51.9K | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,004 | 0 | $96.6K | +$43.5K | 0.0% |
| Kestra Advisory Services, LLC | 12,000 | 0 | $38.6K | +$17.4K | 0.0% |
| NewEdge Advisors, LLC | 10,600 | 0 | $34.1K | +$15.4K | 0.0% |
| UBS Group AG | 81,121 | -59,556 | $261.2K | +$12.2K | -42.3% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 15,556 | 0 | $39.7K | +$8.2K | 0.0% |
| MAI Capital Management | 4,410 | 0 | $14.2K | +$6.4K | 0.0% |
| WELLS FARGO & COMPANY/MN | 2,650 | 0 | $8.5K | +$3.8K | 0.0% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| XTX Topco Ltd | 0 | -54,202 | $0 | -$95.9K | — |
| Kovitz Investment Group Partners, LLC | 0 | -47,578 | $0 | -$84.2K | — |
| Squarepoint Ops LLC | 0 | -38,537 | $0 | -$68.2K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -27,323 | $0 | -$48.4K | — |
| JPMORGAN CHASE & CO | 0 | -26,280 | $0 | -$46.5K | — |
| HighTower Advisors, LLC | 0 | -11,574 | $0 | -$20.5K | — |
| Bison Wealth, LLC | 0 | -10,750 | $0 | -$19.8K | — |
| Creekmur Asset Management LLC | 0 | -4,440 | $0 | -$7.9K | — |
| SRS Capital Advisors, Inc. | 0 | -3,250 | $0 | -$5.8K | — |
| Virtu Financial LLC | 0 | -54,008 | $0 | -$96 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| MARSHALL WACE, LLP | 1,662,293 | $5.4M | +1,487,186 | 849.3% |
| Potomac Capital Management, Inc. | 1,010,000 | $3.3M | +1,010,000 | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 728,949 | $2.3M | +648,514 | 806.3% |
| JONES FINANCIAL COMPANIES LLLP | 702,213 | $2.3M | +25,391 | 3.8% |
| VANGUARD GROUP INC | 569,901 | $1.8M | +35,549 | 6.7% |
| DME Capital Management, LP | 566,130 | $1.8M | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 397,942 | $1.3M | +53,796 | 15.6% |
| JANE STREET GROUP, LLC | 242,328 | $780.3K | +169,878 | 234.5% |
| BlackRock, Inc. | 209,579 | $674.8K | +93,395 | 80.4% |
| Cresset Asset Management, LLC | 160,000 | $515.2K | +160,000 | — |
| STATE STREET CORP | 157,537 | $507.3K | +66,400 | 72.8% |
| MORGAN STANLEY | 147,591 | $475.2K | -8,084 | -5.2% |
| LPL Financial LLC | 106,550 | $343.1K | +106,550 | — |
| NORTHERN TRUST CORP | 102,001 | $328.4K | +13,602 | 15.4% |
| UBS Group AG | 81,121 | $261.2K | -59,556 | -42.3% |
| Focus Partners Wealth | 77,855 | $250.7K | +77,855 | — |
| CITADEL ADVISORS LLC | 77,500 | $249.6K | -306,358 | -79.8% |
| GROUP ONE TRADING, L.P. | 54,159 | $174.4K | +37,384 | 222.8% |
| SIMPLEX TRADING, LLC | 47,946 | $154.4K | +47,946 | — |
| BENEDICT FINANCIAL ADVISORS INC | 38,000 | $122.4K | +3,000 | 8.6% |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
- XTX Topco Ltd$95.9K
- Kovitz Investment Group Partners, LLC$84.2K
- Squarepoint Ops LLC$68.2K
- TWO SIGMA SECURITIES, LLC$48.4K
- JPMORGAN CHASE & CO$46.5K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for GANX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.