13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q4 2024 · Filed February 14, 2025 · Accession 0001104659-25-014085
Total Value
$9.36B
Positions
95
Other Managers
0
Confidential Omitted
No
Holdings (95)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Incyte Corporation | INCY | 30,739,466 | $2.12B | 22.68% |
| 2 | BeiGene, Ltd. | BEIGF | 9,531,880 | $1.76B | 18.81% |
| 3 | ACADIA Pharmaceuticals Inc. | ACAD | 42,877,916 | $786.8M | 8.40% |
| 4 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,974,590 | $609.3M | 6.51% |
| 5 | Summit Therapeutics Inc. | SMMT | 24,424,865 | $435.9M | 4.66% |
| 6 | Revolution Medicines, Inc. | RVMDW | 7,936,972 | $347.2M | 3.71% |
| 7 | Insmed Incorporated | INSM | 5,006,863 | $345.7M | 3.69% |
| 8 | Rhythm Pharmaceuticals, Inc. | RYTM | 6,084,249 | $340.6M | 3.64% |
| 9 | Kymera Therapeutics, Inc. | KYMR | 5,995,929 | $241.2M | 2.58% |
| 10 | Kodiak Sciences Inc. | KOD | 17,310,490 | $172.2M | 1.84% |
| 11 | Edgewise Therapeutics, Inc. | EWTX | 6,155,940 | $164.4M | 1.76% |
| 12 | Bicycle Therapeutics plc | BCYC | 10,885,357 | $152.4M | 1.63% |
| 13 | Replimune Group, Inc. | REPL | 11,045,336 | $133.8M | 1.43% |
| 14 | Alkermes plc | ALKS | 4,181,751 | $120.3M | 1.28% |
| 15 | Insmed Incorporated | INSM | 42,850,000 | $92.9M | 0.99% |
| 16 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $84.1M | 0.90% |
| 17 | AbCellera Biologics Inc. | ABCL | 27,525,640 | $80.7M | 0.86% |
| 18 | Denali Therapeutics Inc. | DNLI | 3,731,695 | $76.1M | 0.81% |
| 19 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $73.1M | 0.78% |
| 20 | argenx SE | ARGX | 111,904 | $68.8M | 0.74% |
| 21 | Ultragenyx Pharmaceutical Inc. | RARE | 1,576,114 | $66.3M | 0.71% |
| 22 | Kiniksa Pharmaceuticals International, plc | G52694109 | 2,818,323 | $55.7M | 0.60% |
| 23 | Immatics N.V. | IMTX | 7,275,830 | $51.7M | 0.55% |
| 24 | CRISPR Therapeutics AG | CRSP | 1,308,011 | $51.5M | 0.55% |
| 25 | Stoke Therapeutics, Inc. | STOK | 4,633,838 | $51.1M | 0.55% |
| 26 | Immunocore Holdings plc | IMCR | 1,515,318 | $44.7M | 0.48% |
| 27 | Roivant Sciences Ltd. | ROIV | 3,767,773 | $44.6M | 0.48% |
| 28 | Sera Prognostics, Inc. | SERA | 5,434,399 | $44.2M | 0.47% |
| 29 | Immunovant, Inc. | IMVT | 1,707,881 | $42.3M | 0.45% |
| 30 | Xenon Pharmaceuticals Inc. | XENE | 993,679 | $39.0M | 0.42% |
| 31 | Celcuity Inc. | CELC | 2,678,553 | $35.1M | 0.37% |
| 32 | Monte Rosa Therapeutics, Inc. | GLUE | 4,916,095 | $34.1M | 0.36% |
| 33 | Akero Therapeutics, Inc. | 00973Y108 | 1,097,082 | $30.5M | 0.33% |
| 34 | Cerus Corporation | CERS | 19,477,339 | $30.0M | 0.32% |
| 35 | Ionis Pharmaceuticals, Inc. | IONS | 30,000,000 | $29.5M | 0.32% |
| 36 | GRAIL, Inc. | GRAL | 1,630,125 | $29.1M | 0.31% |
| 37 | IDEAYA Biosciences, Inc. | IDYA | 1,062,123 | $27.3M | 0.29% |
| 38 | Krystal Biotech, Inc. | KRYS | 169,934 | $26.6M | 0.28% |
| 39 | Candel Therapeutics, Inc. | CADL | 2,981,983 | $25.9M | 0.28% |
| 40 | Praxis Precision Medicines, Inc. | PRAX | 331,533 | $25.5M | 0.27% |
| 41 | IGM Biosciences, Inc. | 449585108 | 4,094,304 | $25.0M | 0.27% |
| 42 | Centessa Pharmaceuticals plc | CNTA | 1,227,178 | $20.6M | 0.22% |
| 43 | Merus N.V. | N5749R100 | 450,000 | $18.9M | 0.20% |
| 44 | Dyne Therapeutics, Inc. | DYN | 672,096 | $15.8M | 0.17% |
| 45 | Neurogene Inc. | NGNE | 674,450 | $15.4M | 0.16% |
| 46 | Xencor, Inc. | XNCR | 670,431 | $15.4M | 0.16% |
| 47 | Bicara Therapeutics Inc. | BCAX | 833,333 | $14.5M | 0.16% |
| 48 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $12.9M | 0.14% |
| 49 | Ionis Pharmaceuticals, Inc. | IONS | 357,915 | $12.5M | 0.13% |
| 50 | Alumis Inc. | ALMS | 1,562,500 | $12.3M | 0.13% |
| 51 | Neumora Therapeutics, Inc. | NMRA | 1,034,600 | $11.0M | 0.12% |
| 52 | Design Therapeutics, Inc. | DSGN | 1,743,725 | $10.8M | 0.11% |
| 53 | Structure Therapeutics Inc. | GPCR | 361,565 | $9.8M | 0.10% |
| 54 | Verve Therapeutics, Inc. | 92539P101 | 1,691,530 | $9.5M | 0.10% |
| 55 | Opthea Limited | OPTEY | 2,173,622 | $8.5M | 0.09% |
| 56 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $8.5M | 0.09% |
| 57 | KALA BIO, Inc. | KALA | 1,201,894 | $8.3M | 0.09% |
| 58 | Vir Biotechnology, Inc. | VIR | 1,084,539 | $8.0M | 0.09% |
| 59 | Mirum Pharmaceuticals, Inc. | MIRM | 190,476 | $7.9M | 0.08% |
| 60 | Arvinas, Inc. | ARVN | 405,576 | $7.8M | 0.08% |
| 61 | Intellia Therapeutics, Inc. | NTLA | 644,116 | $7.5M | 0.08% |
| 62 | 2seventy bio, Inc. | 901384107 | 2,497,526 | $7.3M | 0.08% |
| 63 | Taysha Gene Therapies, Inc. | TSHA | 4,004,756 | $6.9M | 0.07% |
| 64 | Celldex Therapeutics, Inc. | CLDX | 247,644 | $6.3M | 0.07% |
| 65 | Biomea Fusion, Inc. | BMEA | 1,451,990 | $5.6M | 0.06% |
| 66 | Fate Therapeutics, Inc. | FATE | 3,258,402 | $5.4M | 0.06% |
| 67 | BioNTech SE | BNTX | 45,031 | $5.1M | 0.05% |
| 68 | Disc Medicine, Inc. | IRON | 77,050 | $4.9M | 0.05% |
| 69 | Relay Therapeutics, Inc. | RLAY | 1,160,117 | $4.8M | 0.05% |
| 70 | Contineum Therapeutics, Inc. | CTNM | 312,500 | $4.6M | 0.05% |
| 71 | DBV Technologies S.A. | DBVTF | 1,461,425 | $4.5M | 0.05% |
| 72 | Sagimet Biosciences Inc. | SGMT | 952,996 | $4.3M | 0.05% |
| 73 | Wave Life Sciences Ltd. | WVE | 344,063 | $4.3M | 0.05% |
| 74 | Skye Bioscience, Inc. | SKYE | 1,450,638 | $4.1M | 0.04% |
| 75 | Vaxcyte, Inc. | PCVX | 48,885 | $4.0M | 0.04% |
| 76 | Sana Biotechnology, Inc. | SANA | 2,380,949 | $3.9M | 0.04% |
| 77 | Leap Therapeutics, Inc. | CYPH | 1,172,175 | $3.4M | 0.04% |
| 78 | Aligos Therapeutics, Inc. | ALGS | 83,055 | $3.3M | 0.04% |
| 79 | Prime Medicine, Inc. | PRME | 1,028,466 | $3.0M | 0.03% |
| 80 | Protara Therapeutics, Inc. | TARA | 536,832 | $2.8M | 0.03% |
| 81 | Enliven Therapeutics, Inc. | ELVN | 114,833 | $2.6M | 0.03% |
| 82 | Arcturus Therapeutics Holdings Inc. | ARCT | 151,329 | $2.6M | 0.03% |
| 83 | Compass Therapeutics, Inc. | CMPX | 1,557,630 | $2.3M | 0.02% |
| 84 | Generation Bio Co. | 37148K100 | 1,944,945 | $2.1M | 0.02% |
| 85 | HOOKIPA Pharma Inc. | HOOK | 812,814 | $1.6M | 0.02% |
| 86 | Mersana Therapeutics, Inc. | 59045L106 | 1,086,115 | $1.6M | 0.02% |
| 87 | vTv Therapeutics, Inc. | VTVT | 97,314 | $1.3M | 0.01% |
| 88 | Rocket Pharmaceuticals, Inc. | RCKTW | 97,079 | $1.2M | 0.01% |
| 89 | PTC Therapeutics, Inc. | PTCT | 20,400 | $920,856 | 0.01% |
| 90 | Century Therapeutics, Inc. | IPSC | 797,460 | $805,435 | 0.01% |
| 91 | PMV Pharmaceuticals, Inc. | PMVP | 322,024 | $486,256 | 0.01% |
| 92 | Acrivon Therapeutics, Inc. | ACRV | 52,885 | $318,368 | 0.00% |
| 93 | Foghorn Therapeutics Inc. | FHTX | 45,027 | $212,527 | 0.00% |
| 94 | Tyra Biosciences, Inc. | TYRA | 10,607 | $147,437 | 0.00% |
| 95 | Surrozen, Inc. | SRZNW | 833,333 | $17,833 | 0.00% |