13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q3 2024 · Filed November 14, 2024 · Accession 0001104659-24-118899
Total Value
$9.65B
Positions
93
Other Managers
0
Confidential Omitted
No
Holdings (93)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | BeiGene, Ltd. | BEIGF | 10,568,897 | $2.37B | 24.59% |
| 2 | Incyte Corporation | INCY | 30,739,020 | $2.03B | 21.06% |
| 3 | ACADIA Pharmaceuticals Inc. | ACAD | 42,877,916 | $659.5M | 6.83% |
| 4 | Summit Therapeutics Inc. | SMMT | 24,424,865 | $534.9M | 5.54% |
| 5 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,974,590 | $419.0M | 4.34% |
| 6 | Revolution Medicines, Inc. | RVMDW | 7,569,090 | $343.3M | 3.56% |
| 7 | Rhythm Pharmaceuticals, Inc. | RYTM | 6,398,366 | $335.2M | 3.47% |
| 8 | Insmed Incorporated | INSM | 4,415,918 | $322.4M | 3.34% |
| 9 | Kymera Therapeutics, Inc. | KYMR | 5,995,929 | $283.8M | 2.94% |
| 10 | Bicycle Therapeutics plc | BCYC | 9,399,960 | $212.7M | 2.20% |
| 11 | Edgewise Therapeutics, Inc. | EWTX | 5,840,059 | $155.9M | 1.62% |
| 12 | Replimune Group, Inc. | REPL | 11,045,336 | $121.1M | 1.25% |
| 13 | Alkermes plc | ALKS | 4,181,751 | $117.0M | 1.21% |
| 14 | Denali Therapeutics Inc. | DNLI | 3,731,695 | $108.7M | 1.13% |
| 15 | Insmed Incorporated | INSM | 42,850,000 | $98.3M | 1.02% |
| 16 | Ultragenyx Pharmaceutical Inc. | RARE | 1,576,114 | $87.6M | 0.91% |
| 17 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $87.2M | 0.90% |
| 18 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $77.8M | 0.81% |
| 19 | Immatics N.V. | IMTX | 6,443,398 | $73.5M | 0.76% |
| 20 | AbCellera Biologics Inc. | ABCL | 27,525,640 | $71.6M | 0.74% |
| 21 | Kiniksa Pharmaceuticals International, plc | G52694109 | 2,818,323 | $70.4M | 0.73% |
| 22 | IGM Biosciences, Inc. | 449585108 | 4,092,310 | $67.7M | 0.70% |
| 23 | argenx SE | ARGX | 111,904 | $60.7M | 0.63% |
| 24 | Stoke Therapeutics, Inc. | STOK | 4,368,443 | $53.7M | 0.56% |
| 25 | Immunocore Holdings plc | IMCR | 1,515,318 | $47.2M | 0.49% |
| 26 | Kodiak Sciences Inc. | KOD | 17,310,490 | $45.2M | 0.47% |
| 27 | Sera Prognostics, Inc. | SERA | 5,434,399 | $42.4M | 0.44% |
| 28 | CRISPR Therapeutics AG | CRSP | 843,075 | $39.6M | 0.41% |
| 29 | Xenon Pharmaceuticals Inc. | XENE | 993,679 | $39.1M | 0.41% |
| 30 | Immunovant, Inc. | IMVT | 1,225,410 | $34.9M | 0.36% |
| 31 | Cerus Corporation | CERS | 19,477,339 | $33.9M | 0.35% |
| 32 | IDEAYA Biosciences, Inc. | IDYA | 1,062,123 | $33.6M | 0.35% |
| 33 | Roivant Sciences Ltd. | ROIV | 2,798,716 | $32.3M | 0.33% |
| 34 | Akero Therapeutics, Inc. | 00973Y108 | 1,097,082 | $31.5M | 0.33% |
| 35 | Krystal Biotech, Inc. | KRYS | 169,934 | $30.9M | 0.32% |
| 36 | Celcuity Inc. | CELC | 1,874,978 | $28.0M | 0.29% |
| 37 | Monte Rosa Therapeutics, Inc. | GLUE | 4,916,095 | $26.1M | 0.27% |
| 38 | Dyne Therapeutics, Inc. | DYN | 672,096 | $24.1M | 0.25% |
| 39 | Biomea Fusion, Inc. | BMEA | 2,108,949 | $21.3M | 0.22% |
| 40 | Bicara Therapeutics Inc. | BCAX | 833,333 | $21.2M | 0.22% |
| 41 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $21.0M | 0.22% |
| 42 | Centessa Pharmaceuticals plc | CNTA | 1,227,178 | $19.6M | 0.20% |
| 43 | Neurogene Inc. | NGNE | 456,015 | $19.1M | 0.20% |
| 44 | Praxis Precision Medicines, Inc. | PRAX | 323,105 | $18.6M | 0.19% |
| 45 | Alumis Inc. | ALMS | 1,562,500 | $16.7M | 0.17% |
| 46 | Merus N.V. | N5749R100 | 300,000 | $15.0M | 0.16% |
| 47 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $13.9M | 0.14% |
| 48 | Neumora Therapeutics, Inc. | NMRA | 1,034,600 | $13.7M | 0.14% |
| 49 | Xencor, Inc. | XNCR | 670,431 | $13.5M | 0.14% |
| 50 | 2seventy bio, Inc. | 901384107 | 2,497,526 | $11.8M | 0.12% |
| 51 | Fate Therapeutics, Inc. | FATE | 2,997,772 | $10.5M | 0.11% |
| 52 | Arvinas, Inc. | ARVN | 405,576 | $10.0M | 0.10% |
| 53 | Sana Biotechnology, Inc. | SANA | 2,380,949 | $9.9M | 0.10% |
| 54 | Design Therapeutics, Inc. | DSGN | 1,743,725 | $9.4M | 0.10% |
| 55 | Ionis Pharmaceuticals, Inc. | IONS | 223,470 | $9.0M | 0.09% |
| 56 | Opthea Limited | OPTEY | 2,173,622 | $8.8M | 0.09% |
| 57 | Celldex Therapeutics, Inc. | CLDX | 247,644 | $8.4M | 0.09% |
| 58 | Relay Therapeutics, Inc. | RLAY | 1,160,117 | $8.2M | 0.09% |
| 59 | Verve Therapeutics, Inc. | 92539P101 | 1,691,530 | $8.2M | 0.08% |
| 60 | Taysha Gene Therapies, Inc. | TSHA | 4,004,756 | $8.0M | 0.08% |
| 61 | Mirum Pharmaceuticals, Inc. | MIRM | 190,476 | $7.4M | 0.08% |
| 62 | Contineum Therapeutics, Inc. | CTNM | 312,500 | $6.0M | 0.06% |
| 63 | Tango Therapeutics, Inc. | TNGX | 750,000 | $5.8M | 0.06% |
| 64 | Skye Bioscience, Inc. | SKYE | 1,434,634 | $5.6M | 0.06% |
| 65 | Vaxcyte, Inc. | PCVX | 48,885 | $5.6M | 0.06% |
| 66 | Crinetics Pharmaceuticals, Inc. | CRNX | 103,927 | $5.3M | 0.06% |
| 67 | DBV Technologies S.A. | DBVTF | 7,307,131 | $5.1M | 0.05% |
| 68 | KALA BIO, Inc. | KALA | 891,335 | $5.1M | 0.05% |
| 69 | Generation Bio Co. | 37148K100 | 1,944,945 | $4.8M | 0.05% |
| 70 | Alector, Inc. | ALEC | 927,264 | $4.3M | 0.04% |
| 71 | Prime Medicine, Inc. | PRME | 1,028,466 | $4.0M | 0.04% |
| 72 | Sagimet Biosciences Inc. | SGMT | 1,381,898 | $3.8M | 0.04% |
| 73 | Structure Therapeutics Inc. | GPCR | 85,500 | $3.8M | 0.04% |
| 74 | Arcturus Therapeutics Holdings Inc. | ARCT | 151,329 | $3.5M | 0.04% |
| 75 | HOOKIPA Pharma Inc. | HOOK | 812,814 | $3.5M | 0.04% |
| 76 | Leap Therapeutics, Inc. | CYPH | 1,172,175 | $3.0M | 0.03% |
| 77 | Enliven Therapeutics, Inc. | ELVN | 114,833 | $2.9M | 0.03% |
| 78 | Compass Therapeutics, Inc. | CMPX | 1,557,630 | $2.9M | 0.03% |
| 79 | Wave Life Sciences Ltd. | WVE | 344,063 | $2.8M | 0.03% |
| 80 | Mersana Therapeutics, Inc. | 59045L106 | 1,086,115 | $2.1M | 0.02% |
| 81 | NewAmsterdam Pharma Company N.V. | NAMSW | 96,711 | $1.6M | 0.02% |
| 82 | Century Therapeutics, Inc. | IPSC | 797,460 | $1.4M | 0.01% |
| 83 | vTv Therapeutics, Inc. | VTVT | 97,314 | $1.3M | 0.01% |
| 84 | Aerovate Therapeutics, Inc. | 008064107 | 628,939 | $1.3M | 0.01% |
| 85 | Pfizer Inc. | PFE | 35,000 | $1.0M | 0.01% |
| 86 | Protara Therapeutics, Inc. | TARA | 536,832 | $982,403 | 0.01% |
| 87 | Aligos Therapeutics, Inc. | ALGS | 83,055 | $719,256 | 0.01% |
| 88 | BioCryst Pharmaceuticals, Inc. | BCRX | 75,778 | $575,913 | 0.01% |
| 89 | PMV Pharmaceuticals, Inc. | PMVP | 322,024 | $479,816 | 0.00% |
| 90 | Foghorn Therapeutics Inc. | FHTX | 45,027 | $419,201 | 0.00% |
| 91 | Acrivon Therapeutics, Inc. | ACRV | 52,885 | $370,195 | 0.00% |
| 92 | Tyra Biosciences, Inc. | TYRA | 10,607 | $249,371 | 0.00% |
| 93 | Surrozen, Inc. | SRZNW | 833,333 | $8,583 | 0.00% |