13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q4 2023 · Filed November 14, 2023 · Accession 0001104659-23-118157
Total Value
$17.35B
Positions
101
Other Managers
0
Confidential Omitted
No
Holdings (101)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Seagen Inc. | SE | 44,554,162 | $9.45B | 54.48% |
| 2 | BeiGene, Ltd. | BEIGF | 11,668,897 | $2.10B | 12.10% |
| 3 | Incyte Corporation | INCY | 36,178,566 | $2.09B | 12.05% |
| 4 | ACADIA Pharmaceuticals Inc. | ACAD | 42,864,612 | $893.3M | 5.15% |
| 5 | BioMarin Pharmaceutical Inc. | BMRN | 3,810,248 | $337.1M | 1.94% |
| 6 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,545,113 | $225.6M | 1.30% |
| 7 | Rhythm Pharmaceuticals, Inc. | RYTM | 6,702,349 | $153.7M | 0.89% |
| 8 | Roivant Sciences Ltd. | ROIV | 11,877,171 | $138.7M | 0.80% |
| 9 | Immunocore Holdings plc | IMCR | 2,520,731 | $130.8M | 0.75% |
| 10 | Invitae Corporation | 46185LAD5 | 300,000,000 | $130.4M | 0.75% |
| 11 | Akero Therapeutics, Inc. | 00973Y108 | 2,368,378 | $119.8M | 0.69% |
| 12 | AbCellera Biologics Inc. | ABCL | 20,763,323 | $95.5M | 0.55% |
| 13 | BioCryst Pharmaceuticals, Inc. | BCRX | 12,710,818 | $90.0M | 0.52% |
| 14 | Replimune Group, Inc. | REPL | 4,578,280 | $78.3M | 0.45% |
| 15 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $76.9M | 0.44% |
| 16 | Revolution Medicines, Inc. | RVMDW | 2,691,493 | $74.5M | 0.43% |
| 17 | argenx SE | ARGX | 151,215 | $74.3M | 0.43% |
| 18 | SpringWorks Therapeutics, Inc. | 85205L107 | 2,999,846 | $69.4M | 0.40% |
| 19 | Kymera Therapeutics, Inc. | KYMR | 4,750,400 | $66.0M | 0.38% |
| 20 | Immatics N.V. | IMTX | 5,640,816 | $65.3M | 0.38% |
| 21 | Mirati Therapeutics, Inc. | 60468T105 | 1,409,784 | $61.4M | 0.35% |
| 22 | Kiniksa Pharmaceuticals, Ltd. | KNSA | 2,809,577 | $48.8M | 0.28% |
| 23 | Ultragenyx Pharmaceutical Inc. | RARE | 1,366,547 | $48.7M | 0.28% |
| 24 | Denali Therapeutics Inc. | DNLI | 2,292,003 | $47.3M | 0.27% |
| 25 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $31.3M | 0.18% |
| 26 | Kodiak Sciences Inc. | KOD | 17,310,490 | $31.2M | 0.18% |
| 27 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $30.5M | 0.18% |
| 28 | Biomea Fusion, Inc. | BMEA | 2,108,949 | $29.0M | 0.17% |
| 29 | IDEAYA Biosciences, Inc. | IDYA | 1,062,123 | $28.7M | 0.17% |
| 30 | Cerus Corporation | CERS | 17,239,501 | $27.9M | 0.16% |
| 31 | Aerovate Therapeutics, Inc. | 008064107 | 1,963,479 | $26.6M | 0.15% |
| 32 | IGM Biosciences, Inc. | 449585108 | 3,157,764 | $26.4M | 0.15% |
| 33 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | $25.7M | 0.15% |
| 34 | Cabaletta Bio, Inc. | CABA | 1,594,000 | $24.3M | 0.14% |
| 35 | Monte Rosa Therapeutics, Inc. | GLUE | 4,916,095 | $23.5M | 0.14% |
| 36 | DBV Technologies S.A. | DBVTF | 14,614,264 | $19.9M | 0.11% |
| 37 | Krystal Biotech, Inc. | KRYS | 169,934 | $19.7M | 0.11% |
| 38 | Verve Therapeutics, Inc. | 92539P101 | 1,416,530 | $18.8M | 0.11% |
| 39 | Bicycle Therapeutics plc | BCYC | 843,814 | $17.0M | 0.10% |
| 40 | Immunovant, Inc. | IMVT | 425,009 | $16.3M | 0.09% |
| 41 | Cogent Biosciences, Inc. | COGT | 1,292,966 | $12.6M | 0.07% |
| 42 | Day One Biopharmaceuticals, Inc. | DAWN | 1,000,000 | $12.3M | 0.07% |
| 43 | Prime Medicine, Inc. | PRME | 1,028,466 | $9.8M | 0.06% |
| 44 | 2seventy bio, Inc. | 901384107 | 2,497,526 | $9.8M | 0.06% |
| 45 | Relay Therapeutics, Inc. | RLAY | 1,160,117 | $9.8M | 0.06% |
| 46 | Pacific Biosciences of California, Inc. | 69404D108 | 1,127,782 | $9.4M | 0.05% |
| 47 | Insmed Incorporated | INSM | 343,000 | $8.7M | 0.05% |
| 48 | Adaptimmune Therapeutics plc | ADTI | 10,969,282 | $8.6M | 0.05% |
| 49 | Tango Therapeutics, Inc. | TNGX | 750,000 | $8.4M | 0.05% |
| 50 | Heron Therapeutics, Inc. | HRTX | 8,131,678 | $8.4M | 0.05% |
| 51 | Arvinas, Inc. | ARVN | 413,481 | $8.1M | 0.05% |
| 52 | Taysha Gene Therapies, Inc. | TSHA | 2,504,756 | $7.9M | 0.05% |
| 53 | Sana Biotechnology, Inc. | SANA | 2,000,000 | $7.7M | 0.04% |
| 54 | bluebird bio, Inc. | 09609G100 | 2,499,715 | $7.6M | 0.04% |
| 55 | ARS Pharmaceuticals, Inc. | SPRY | 2,006,451 | $7.6M | 0.04% |
| 56 | Sagimet Biosciences Inc. | SGMT | 815,359 | $7.2M | 0.04% |
| 57 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $7.1M | 0.04% |
| 58 | Geron Corporation | GERN | 3,061,224 | $6.5M | 0.04% |
| 59 | Athira Pharma, Inc. | 04746L104 | 3,153,807 | $6.4M | 0.04% |
| 60 | Alector, Inc. | ALEC | 964,851 | $6.3M | 0.04% |
| 61 | Invitae Corporation | 46185LAH6 | 9,274,000 | $6.2M | 0.04% |
| 62 | Mirum Pharmaceuticals, Inc. | MIRM | 190,476 | $6.0M | 0.03% |
| 63 | Edgewise Therapeutics, Inc. | EWTX | 1,049,699 | $6.0M | 0.03% |
| 64 | Summit Therapeutics Inc. | SMMT | 3,140,473 | $5.9M | 0.03% |
| 65 | Stoke Therapeutics, Inc. | STOK | 1,485,915 | $5.9M | 0.03% |
| 66 | HOOKIPA Pharma Inc. | HOOK | 8,065,398 | $5.0M | 0.03% |
| 67 | Morphic Holding, Inc. | 61775R105 | 215,800 | $4.9M | 0.03% |
| 68 | Celcuity Inc. | CELC | 535,478 | $4.9M | 0.03% |
| 69 | Neoleukin Therapeutics, Inc. | 64049K203 | 1,221,414 | $4.8M | 0.03% |
| 70 | Aadi Bioscience, Inc. | WHWK | 989,928 | $4.8M | 0.03% |
| 71 | Opthea Limited | OPTEY | 2,690,891 | $4.7M | 0.03% |
| 72 | Natera, Inc. | NTRA | 100,000 | $4.4M | 0.03% |
| 73 | Design Therapeutics, Inc. | DSGN | 1,500,000 | $3.5M | 0.02% |
| 74 | Praxis Precision Medicines, Inc. | PRAX | 1,879,915 | $3.2M | 0.02% |
| 75 | Compass Therapeutics, Inc. | CMPX | 1,557,630 | $3.1M | 0.02% |
| 76 | Talis Biomedical Corporation | 87424L207 | 508,323 | $2.9M | 0.02% |
| 77 | Gracell Biotechnologies Inc. | 38406L103 | 1,000,000 | $2.9M | 0.02% |
| 78 | Sera Prognostics, Inc. | SERA | 1,515,342 | $2.8M | 0.02% |
| 79 | Vaxcyte, Inc. | PCVX | 48,885 | $2.5M | 0.01% |
| 80 | Xencor, Inc. | XNCR | 123,127 | $2.5M | 0.01% |
| 81 | KALA BIO, Inc. | KALA | 266,613 | $2.4M | 0.01% |
| 82 | Achilles Therapeutics plc | 00449L102 | 2,557,149 | $2.3M | 0.01% |
| 83 | Century Therapeutics, Inc. | IPSC | 1,149,340 | $2.3M | 0.01% |
| 84 | Affimed N.V. | N01045108 | 4,448,644 | $2.1M | 0.01% |
| 85 | Perspective Therapeutics, Inc. | CATX | 7,639,703 | $2.1M | 0.01% |
| 86 | Instil Bio, Inc. | TIL | 4,704,395 | $2.0M | 0.01% |
| 87 | PMV Pharmaceuticals, Inc. | PMVP | 322,024 | $2.0M | 0.01% |
| 88 | AnaptysBio, Inc. | ANABV | 106,197 | $1.9M | 0.01% |
| 89 | POINT Biopharma Global Inc. | 730541109 | 249,968 | $1.7M | 0.01% |
| 90 | iTeos Therapeutics, Inc. | 46565G104 | 150,346 | $1.6M | 0.01% |
| 91 | Leap Therapeutics, Inc. | CYPH | 1,172,175 | $1.6M | 0.01% |
| 92 | Aligos Therapeutics, Inc. | ALGS | 2,076,400 | $1.6M | 0.01% |
| 93 | Mersana Therapeutics, Inc. | 59045L106 | 1,086,115 | $1.4M | 0.01% |
| 94 | Vor Biopharma Inc. | VOR | 633,848 | $1.3M | 0.01% |
| 95 | Invitae Corporation | 46185L103 | 1,764,546 | $1.1M | 0.01% |
| 96 | Avidity Biosciences, Inc. | 05370A108 | 166,347 | $1.1M | 0.01% |
| 97 | Atreca, Inc. | 04965G109 | 3,532,760 | $922,050 | 0.01% |
| 98 | Genetron Holdings Limited | 37186H100 | 455,306 | $369,754 | 0.00% |
| 99 | Protara Therapeutics, Inc. | TARA | 199,671 | $333,451 | 0.00% |
| 100 | Foghorn Therapeutics Inc. | FHTX | 45,027 | $225,135 | 0.00% |
| 101 | Surrozen, Inc. | SRZNW | 833,333 | $34,250 | 0.00% |