13F HOLDINGS REPORT
Tekla Capital Management LLC
Quarter ended Q3 2023 · Filed August 10, 2023 · Accession 0001104659-23-089542
Total Value
$2.56B
Positions
166
Other Managers
0
Confidential Omitted
No
Holdings (166)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Amgen Inc. | AMGN | 616,539 | $136.9M | 5.36% |
| 2 | Johnson & Johnson | JNJ | 721,779 | $119.5M | 4.68% |
| 3 | Gilead Sciences, Inc. | GILD | 1,533,884 | $118.2M | 4.63% |
| 4 | Regeneron Pharmaceuticals, Inc. | REGN | 161,418 | $116.0M | 4.54% |
| 5 | Vertex Pharmaceuticals Inc. | VRTX | 318,043 | $111.9M | 4.38% |
| 6 | Eli Lilly and Company | LLY | 213,352 | $100.1M | 3.92% |
| 7 | Unitedhealth Group Inc. | UNH | 206,961 | $99.5M | 3.89% |
| 8 | Merck & Co., Inc. | MRK | 728,154 | $84.0M | 3.29% |
| 9 | AbbVie Inc. | ABBV | 545,629 | $73.5M | 2.88% |
| 10 | Biogen Inc. | BIIB | 247,943 | $70.6M | 2.76% |
| 11 | AstraZeneca PLC | AZN | 976,676 | $69.9M | 2.74% |
| 12 | Illumina, Inc. | ILMN | 336,979 | $63.2M | 2.47% |
| 13 | Abbott Laboratories | ABLZF | 552,455 | $60.2M | 2.36% |
| 14 | Pfizer Inc. | PFE | 1,624,476 | $59.6M | 2.33% |
| 15 | Thermo Fisher Scientific Inc. | TMO | 98,987 | $51.6M | 2.02% |
| 16 | Elevance Health, Inc. | ELV | 114,070 | $50.7M | 1.98% |
| 17 | Moderna, Inc. | MRNA | 343,695 | $41.8M | 1.63% |
| 18 | Boston Scientific Corp. | BSX | 657,790 | $35.6M | 1.39% |
| 19 | Danaher Corp. | 235851102 | 142,813 | $34.3M | 1.34% |
| 20 | Medtronic plc | MDT | 344,417 | $30.3M | 1.19% |
| 21 | IDEXX Laboratories, Inc. | 45168D104 | 58,595 | $29.4M | 1.15% |
| 22 | Dexcom, Inc. | DXCM | 228,747 | $29.4M | 1.15% |
| 23 | Bristol-Myers Squibb Company | CELG-RI | 458,498 | $29.3M | 1.15% |
| 24 | Intuitive Surgical, Inc. | ISRG | 83,980 | $28.7M | 1.12% |
| 25 | Alnylam Pharmaceuticals, Inc. | ALNY | 143,214 | $27.2M | 1.06% |
| 26 | The Cigna Group | 125523100 | 96,339 | $27.0M | 1.06% |
| 27 | McKesson Corp. | MCK | 61,955 | $26.5M | 1.04% |
| 28 | argenx SE | ARGX | 65,553 | $25.5M | 1.00% |
| 29 | HCA Healthcare, Inc. | HCA | 82,403 | $25.0M | 0.98% |
| 30 | Stryker Corp. | SYK | 81,128 | $24.8M | 0.97% |
| 31 | IQVIA Holdings Inc. | IQV | 109,129 | $24.5M | 0.96% |
| 32 | Zoetis Inc. | ZTS | 136,914 | $23.6M | 0.92% |
| 33 | Charles River Laboratories International, Inc. | 159864107 | 111,183 | $23.4M | 0.91% |
| 34 | Seagen Inc. | SE | 112,331 | $21.6M | 0.85% |
| 35 | Sarepta Therapeutics, Inc. | SRPT | 179,437 | $20.5M | 0.80% |
| 36 | Novo Nordisk A/S | NONOF | 122,777 | $19.9M | 0.78% |
| 37 | Oculis Holding AG | OCSAW | 1,690,741 | $18.8M | 0.74% |
| 38 | Molina Healthcare, Inc. | MOH | 61,856 | $18.6M | 0.73% |
| 39 | Jazz Pharmaceuticals plc | JAZZ | 147,779 | $18.3M | 0.72% |
| 40 | BioMarin Pharmaceutical Inc. | BMRN | 210,789 | $18.3M | 0.72% |
| 41 | Edwards Lifesciences Corp. | EW | 189,597 | $17.9M | 0.70% |
| 42 | Humana Inc. | HUM | 36,794 | $16.5M | 0.64% |
| 43 | Apellis Pharmaceuticals, Inc. | APLS | 173,248 | $15.8M | 0.62% |
| 44 | Baxter International, Inc. | 071813109 | 324,370 | $14.8M | 0.58% |
| 45 | Exelixis, Inc. | EXEL | 726,639 | $13.9M | 0.54% |
| 46 | Novartis AG | NVSEF | 136,225 | $13.7M | 0.54% |
| 47 | Karuna Therapeutics, Inc. | 48576A100 | 58,577 | $12.7M | 0.50% |
| 48 | Insulet Corp. | PODD | 43,847 | $12.6M | 0.49% |
| 49 | Guardant Health, Inc. | GH | 346,084 | $12.4M | 0.48% |
| 50 | Ascendis Pharma A/S | ASND | 138,791 | $12.4M | 0.48% |
| 51 | SPDR S&P Biotech ETF | 78464A870 | 147,677 | $12.3M | 0.48% |
| 52 | Physicians Realty Trust | 71943U104 | 873,655 | $12.2M | 0.48% |
| 53 | Tenet Healthcare Corp. | THC | 149,070 | $12.1M | 0.47% |
| 54 | BioNTech SE | BNTX | 103,858 | $11.2M | 0.44% |
| 55 | Neurocrine Biosciences, Inc. | NBIX | 112,908 | $10.6M | 0.42% |
| 56 | Zimmer Biomet Holdings, Inc. | ZBH | 67,356 | $9.8M | 0.38% |
| 57 | Rallybio Corporation | RLYB | 1,727,067 | $9.8M | 0.38% |
| 58 | Vaxcyte, Inc. | PCVX | 194,232 | $9.7M | 0.38% |
| 59 | Alkermes plc | ALKS | 309,613 | $9.7M | 0.38% |
| 60 | Denali Therapeutics, Inc. | DNLI | 324,829 | $9.6M | 0.38% |
| 61 | Avantor, Inc. | AVTR | 459,488 | $9.4M | 0.37% |
| 62 | Omega Healthcare Investors, Inc. | 681936100 | 306,433 | $9.4M | 0.37% |
| 63 | United Therapeutics Corp. | UTHR | 41,465 | $9.2M | 0.36% |
| 64 | Intra-Cellular Therapies, Inc. | 46116X101 | 131,435 | $8.3M | 0.33% |
| 65 | Acadia Healthcare Company, Inc. | ACHC | 100,912 | $8.0M | 0.31% |
| 66 | Madrigal Pharmaceuticals, Inc. | MDGL | 34,434 | $8.0M | 0.31% |
| 67 | ResMed Inc. | RSMDF | 34,704 | $7.6M | 0.30% |
| 68 | Horizon Therapeutics plc | G46188101 | 72,425 | $7.4M | 0.29% |
| 69 | Inspire Medical Systems, Inc. | 457730109 | 22,018 | $7.1M | 0.28% |
| 70 | Cytokinetics, Inc. | CYTK | 219,025 | $7.1M | 0.28% |
| 71 | STERIS plc | STE | 31,072 | $7.0M | 0.27% |
| 72 | Sanofi | SNYNF | 123,454 | $6.7M | 0.26% |
| 73 | R1 RCM Inc. | 77634L105 | 356,851 | $6.6M | 0.26% |
| 74 | CVS Health Corp. | CVS | 93,621 | $6.5M | 0.25% |
| 75 | Medpace Holdings, Inc. | MEDP | 26,918 | $6.5M | 0.25% |
| 76 | Immunovant, Inc. | IMVT | 336,200 | $6.4M | 0.25% |
| 77 | Intellia Therapeutics, Inc. | NTLA | 154,269 | $6.3M | 0.25% |
| 78 | LTC Properties, Inc. | 502175102 | 182,293 | $6.0M | 0.24% |
| 79 | Sabra Health Care REIT, Inc. | SBRA | 510,660 | $6.0M | 0.24% |
| 80 | Smith & Nephew plc | SNNUF | 181,710 | $5.9M | 0.23% |
| 81 | Chinook Therapeutics, Inc. | 16961L106 | 150,863 | $5.8M | 0.23% |
| 82 | West Pharmaceutical Services, Inc. | 955306105 | 15,036 | $5.8M | 0.23% |
| 83 | Cerevel Therapeutics Holdings, Inc. | 15678U128 | 176,483 | $5.6M | 0.22% |
| 84 | LivaNova plc | LIVN | 108,480 | $5.6M | 0.22% |
| 85 | Veradigm, Inc. | 01988P108 | 428,580 | $5.4M | 0.21% |
| 86 | Agilent Technologies, Inc. | A | 43,191 | $5.2M | 0.20% |
| 87 | Marinus Pharmaceuticals, Inc. | 56854Q200 | 411,101 | $4.5M | 0.17% |
| 88 | uniQure N.V. | QURE | 356,280 | $4.1M | 0.16% |
| 89 | Amerisourcebergen Corp. | COR | 20,417 | $3.9M | 0.15% |
| 90 | Medical Properties Trust, Inc. | 58463J304 | 411,743 | $3.8M | 0.15% |
| 91 | BeiGene, Ltd. | BEIGF | 20,952 | $3.7M | 0.15% |
| 92 | Ionis Pharmaceuticals, Inc. | IONS | 87,840 | $3.6M | 0.14% |
| 93 | BioCryst Pharmaceuticals, Inc. | BCRX | 504,528 | $3.6M | 0.14% |
| 94 | Reata Pharmaceuticals, Inc. Class A | 75615P103 | 34,250 | $3.5M | 0.14% |
| 95 | Teva Pharmaceutical Industries Ltd. | 881624209 | 459,651 | $3.5M | 0.14% |
| 96 | Welltower Inc. | WELL | 41,484 | $3.4M | 0.13% |
| 97 | Healthcare Realty Trust Inc. | 42226K105 | 174,686 | $3.3M | 0.13% |
| 98 | Ventas, Inc. | VTR | 66,681 | $3.2M | 0.12% |
| 99 | Ishares Biothechnology ETF | 464287556 | 24,569 | $3.1M | 0.12% |
| 100 | Healthpeak Properties, Inc. | DOC | 150,392 | $3.0M | 0.12% |
| 101 | Akero Therapeutics, Inc. | 00973Y108 | 61,497 | $2.9M | 0.11% |
| 102 | Adaptive Biotechnologies Corp. | ADTI | 422,281 | $2.8M | 0.11% |
| 103 | Galera Therapeutics, Inc. | GRTX | 898,374 | $2.8M | 0.11% |
| 104 | Xenon Pharmaceuticals Inc. | XENE | 67,506 | $2.6M | 0.10% |
| 105 | Bridgebio Pharma, Inc. | BBIO | 150,921 | $2.6M | 0.10% |
| 106 | Koninklijke Philips N.V. | RYLPF | 114,765 | $2.5M | 0.10% |
| 107 | Caribou Biosciences, Inc. | CRBU | 567,147 | $2.4M | 0.09% |
| 108 | Mirati Therapeutics, Inc. | 60468T105 | 65,490 | $2.4M | 0.09% |
| 109 | Icon plc | ICLR | 9,334 | $2.3M | 0.09% |
| 110 | Amylyx Pharmaceuticals, Inc. | AMLX | 104,007 | $2.2M | 0.09% |
| 111 | Assertio Holdings, Inc. | ASRT | 410,575 | $2.2M | 0.09% |
| 112 | Mereo BioPharma Group plc | MREO | 1,551,082 | $2.0M | 0.08% |
| 113 | 89bio, Inc. | 282559103 | 105,898 | $2.0M | 0.08% |
| 114 | Ardelyx, Inc. | ARDX | 539,408 | $1.8M | 0.07% |
| 115 | Pyxis Oncology, Inc. | PYXS | 708,303 | $1.8M | 0.07% |
| 116 | Perrigo Company plc | PRGO | 51,224 | $1.7M | 0.07% |
| 117 | Takeda Pharmaceutical Company Ltd. | TKPHF | 105,073 | $1.7M | 0.06% |
| 118 | Global Medical REIT Inc. | 37954A204 | 174,897 | $1.6M | 0.06% |
| 119 | GSK plc | GLAXF | 41,852 | $1.5M | 0.06% |
| 120 | Tactile Systems Technology, Inc. | 87357P100 | 58,472 | $1.5M | 0.06% |
| 121 | Arcutis Biotherapeutics, Inc. | ARQT | 148,874 | $1.4M | 0.06% |
| 122 | Xencor, Inc. | XNCR | 56,675 | $1.4M | 0.06% |
| 123 | Crinetics Pharmaceuticals, Inc. | CRNX | 78,529 | $1.4M | 0.06% |
| 124 | MorphoSys AG | 617760202 | 177,191 | $1.3M | 0.05% |
| 125 | CRISPR Therapeutics AG | CRSP | 22,571 | $1.3M | 0.05% |
| 126 | Natera, Inc. | NTRA | 24,636 | $1.2M | 0.05% |
| 127 | Edgewise Therapeutics, Inc. | EWTX | 150,418 | $1.2M | 0.05% |
| 128 | Zentalis Pharmaceuticals, Inc. | ZNTL | 40,156 | $1.1M | 0.04% |
| 129 | Bicycle Therapeutics PLC | BCYC | 44,338 | $1.1M | 0.04% |
| 130 | G1 Therapeutics, Inc. | 3621LQ109 | 423,869 | $1.1M | 0.04% |
| 131 | Fulcrum Therapeutics, Inc. | FULC | 256,888 | $847,730 | 0.03% |
| 132 | Scholar Rock Holding Corp. | SRRK | 108,833 | $820,601 | 0.03% |
| 133 | Diversified Healthcare Trust | DHCNL | 357,720 | $804,870 | 0.03% |
| 134 | Theseus Pharmaceuticals, Inc. | 88369M101 | 75,000 | $699,750 | 0.03% |
| 135 | Arcus Biosciences, Inc. | RCUS | 32,839 | $666,960 | 0.03% |
| 136 | Black Diamond Therapeutics, Inc. | BDTX | 131,990 | $666,550 | 0.03% |
| 137 | iTeos Therapeutics, Inc. | 46565G104 | 45,735 | $605,531 | 0.02% |
| 138 | Intercept Pharmaceuticals, Inc. | INTR | 52,067 | $575,861 | 0.02% |
| 139 | Universal Health Realty Income Trust | 91359E105 | 11,258 | $535,656 | 0.02% |
| 140 | National Health Investors, Inc. | 63633D104 | 10,038 | $526,192 | 0.02% |
| 141 | Beam Therapeutics Inc. | BEAM | 15,817 | $505,037 | 0.02% |
| 142 | TScan Therapeutics, Inc. | TCRX | 200,000 | $500,000 | 0.02% |
| 143 | ALX Oncology Holdings Inc. | ALXO | 66,211 | $497,245 | 0.02% |
| 144 | Community Healthcare Trust Inc. | CHCT | 14,900 | $491,998 | 0.02% |
| 145 | I-Mab | NBP | 162,580 | $486,114 | 0.02% |
| 146 | Novavax, Inc. | NVAX | 63,800 | $474,034 | 0.02% |
| 147 | HilleVax, Inc. | 43157M102 | 27,000 | $464,130 | 0.02% |
| 148 | Sutro Biopharma, Inc. | STRO | 98,354 | $457,346 | 0.02% |
| 149 | Community Health Systems, Inc. | 203668108 | 88,335 | $388,674 | 0.02% |
| 150 | Affimed N.V. | N01045108 | 586,038 | $350,568 | 0.01% |
| 151 | Repare Therapeutics Inc. | 760273102 | 29,150 | $308,407 | 0.01% |
| 152 | Altimmune, Inc. | ALT | 75,000 | $264,750 | 0.01% |
| 153 | Fusion Pharmaceuticals Inc. | 36118A100 | 43,394 | $203,084 | 0.01% |
| 154 | Codexis Inc | CDXS | 69,125 | $193,550 | 0.01% |
| 155 | Harpoon Therapeutics, Inc. | 41358P106 | 259,910 | $184,536 | 0.01% |
| 156 | Precision BioSciences, Inc. | DTIL | 224,534 | $118,105 | 0.00% |
| 157 | Spectrum Pharmaceuticals, Inc. | 84763A108 | 114,670 | $110,083 | 0.00% |
| 158 | Adicet Bio, Inc. | ACET | 40,329 | $97,999 | 0.00% |
| 159 | Praxis Precision Medicines, Inc. | PRAX | 75,000 | $86,250 | 0.00% |
| 160 | ARCA biopharma, Inc. | 00211Y506 | 32,461 | $65,896 | 0.00% |
| 161 | Nkarta, Inc. | NKTX | 28,988 | $63,484 | 0.00% |
| 162 | Mallinckrodt plc | G5890A102 | 35,048 | $41,357 | 0.00% |
| 163 | Corbus Pharmaceuticals Holdings, Inc. | CRBP | 5,143 | $40,321 | 0.00% |
| 164 | VYNE Therapeutics, Inc. | VYNE | 7,520 | $30,531 | 0.00% |
| 165 | NexGel, Inc. | NXGLW | 4,243 | $10,650 | 0.00% |
| 166 | Bellicum Pharmaceuticals, Inc. | 079481404 | 6,000 | $2,220 | 0.00% |