13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q2 2023 · Filed May 15, 2023 · Accession 0001104659-23-060720
Total Value
$18.38B
Positions
105
Other Managers
0
Confidential Omitted
No
Holdings (105)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Seagen Inc. | SE | 46,913,769 | $9.50B | 51.68% |
| 2 | Incyte Corporation | INCY | 36,175,400 | $2.61B | 14.22% |
| 3 | BeiGene, Ltd. | BEIGF | 11,668,897 | $2.51B | 13.68% |
| 4 | ACADIA Pharmaceuticals Inc. | ACAD | 41,938,486 | $789.3M | 4.29% |
| 5 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,545,113 | $374.3M | 2.04% |
| 6 | BioMarin Pharmaceutical Inc. | BMRN | 3,810,248 | $370.5M | 2.02% |
| 7 | Immunocore Holdings plc | IMCR | 2,520,731 | $124.6M | 0.68% |
| 8 | Rhythm Pharmaceuticals, Inc. | RYTM | 6,498,267 | $115.9M | 0.63% |
| 9 | Kodiak Sciences Inc. | KOD | 17,310,490 | $107.3M | 0.58% |
| 10 | BioCryst Pharmaceuticals, Inc. | BCRX | 12,710,818 | $106.0M | 0.58% |
| 11 | argenx SE | ARGX | 280,159 | $104.4M | 0.57% |
| 12 | Akero Therapeutics, Inc. | 00973Y108 | 2,368,378 | $90.6M | 0.49% |
| 13 | Kymera Therapeutics, Inc. | KYMR | 2,879,825 | $85.3M | 0.46% |
| 14 | Replimune Group, Inc. | REPL | 4,578,280 | $80.9M | 0.44% |
| 15 | AbCellera Biologics Inc. | ABCL | 10,450,180 | $78.8M | 0.43% |
| 16 | SpringWorks Therapeutics, Inc. | 85205L107 | 2,753,502 | $70.9M | 0.39% |
| 17 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $70.6M | 0.38% |
| 18 | Biomea Fusion, Inc. | BMEA | 2,108,949 | $65.4M | 0.36% |
| 19 | Revolution Medicines, Inc. | RVMDW | 2,691,493 | $58.3M | 0.32% |
| 20 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $57.7M | 0.31% |
| 21 | Mirati Therapeutics, Inc. | 60468T105 | 1,409,784 | $52.4M | 0.29% |
| 22 | FibroGen, Inc. | 31572Q808 | 2,637,384 | $49.2M | 0.27% |
| 23 | Cerus Corporation | CERS | 16,067,558 | $47.7M | 0.26% |
| 24 | IGM Biosciences, Inc. | 449585108 | 3,156,656 | $43.4M | 0.24% |
| 25 | Aerovate Therapeutics, Inc. | 008064107 | 1,963,479 | $39.6M | 0.22% |
| 26 | Immatics N.V. | IMTX | 5,187,081 | $35.8M | 0.19% |
| 27 | Roivant Sciences Ltd. | ROIV | 4,777,430 | $35.3M | 0.19% |
| 28 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $34.5M | 0.19% |
| 29 | Chinook Therapeutics, Inc. | 16961L106 | 1,455,202 | $33.7M | 0.18% |
| 30 | Kiniksa Pharmaceuticals, Ltd. | KNSA | 2,799,577 | $30.1M | 0.16% |
| 31 | DICE Therapeutics, Inc. | 23345J104 | 1,035,786 | $29.7M | 0.16% |
| 32 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | $26.9M | 0.15% |
| 33 | 2seventy bio, Inc. | 901384107 | 2,497,526 | $25.5M | 0.14% |
| 34 | Denali Therapeutics Inc. | DNLI | 1,088,738 | $25.1M | 0.14% |
| 35 | DBV Technologies S.A. | DBVTF | 14,614,264 | $24.7M | 0.13% |
| 36 | Krystal Biotech, Inc. | KRYS | 302,716 | $24.2M | 0.13% |
| 37 | Verve Therapeutics, Inc. | 92539P101 | 1,416,530 | $20.4M | 0.11% |
| 38 | Ultragenyx Pharmaceutical Inc. | RARE | 470,974 | $18.9M | 0.10% |
| 39 | Bicycle Therapeutics plc | BCYC | 843,814 | $17.9M | 0.10% |
| 40 | Stoke Therapeutics, Inc. | STOK | 2,115,416 | $17.6M | 0.10% |
| 41 | AnaptysBio, Inc. | ANABV | 775,924 | $16.9M | 0.09% |
| 42 | Avidity Biosciences, Inc. | 05370A108 | 1,004,051 | $15.4M | 0.08% |
| 43 | Blueprint Medicines Corporation | 09627Y109 | 333,665 | $15.0M | 0.08% |
| 44 | ARS Pharmaceuticals, Inc. | SPRY | 2,006,451 | $13.1M | 0.07% |
| 45 | Pacific Biosciences of California, Inc. | 69404D108 | 1,127,782 | $13.1M | 0.07% |
| 46 | Prime Medicine, Inc. | PRME | 1,028,466 | $12.7M | 0.07% |
| 47 | Heron Therapeutics, Inc. | HRTX | 8,131,678 | $12.3M | 0.07% |
| 48 | Invitae Corporation | 46185L103 | 8,881,104 | $12.0M | 0.07% |
| 49 | IDEAYA Biosciences, Inc. | IDYA | 832,769 | $11.4M | 0.06% |
| 50 | Cabaletta Bio, Inc. | CABA | 1,344,000 | $11.1M | 0.06% |
| 51 | Summit Therapeutics Inc. | SMMT | 6,304,705 | $11.0M | 0.06% |
| 52 | Adaptimmune Therapeutics plc | ADTI | 9,830,877 | $10.7M | 0.06% |
| 53 | Opthea Limited | OPTEY | 2,691,391 | $10.6M | 0.06% |
| 54 | Verastem, Inc. | VSTM | 25,521,447 | $10.6M | 0.06% |
| 55 | Fate Therapeutics, Inc. | FATE | 1,671,717 | $9.5M | 0.05% |
| 56 | POINT Biopharma Global Inc. | 730541109 | 1,169,103 | $8.5M | 0.05% |
| 57 | bluebird bio, Inc. | 09609G100 | 2,499,715 | $7.9M | 0.04% |
| 58 | Allogene Therapeutics, Inc. | ALLO | 1,576,901 | $7.8M | 0.04% |
| 59 | Mersana Therapeutics, Inc. | 59045L106 | 1,886,115 | $7.8M | 0.04% |
| 60 | Aadi Bioscience, Inc. | WHWK | 989,928 | $7.2M | 0.04% |
| 61 | Sera Prognostics, Inc. | SERA | 1,789,000 | $6.9M | 0.04% |
| 62 | Geron Corporation | GERN | 3,061,224 | $6.6M | 0.04% |
| 63 | Sana Biotechnology, Inc. | SANA | 2,000,000 | $6.5M | 0.04% |
| 64 | Aravive, Inc. | 03890D108 | 3,261,224 | $6.5M | 0.04% |
| 65 | MacroGenics, Inc. | MGNX | 892,579 | $6.4M | 0.03% |
| 66 | Alector, Inc. | ALEC | 964,851 | $6.0M | 0.03% |
| 67 | Athira Pharma, Inc. | 04746L104 | 2,350,355 | $5.9M | 0.03% |
| 68 | Insmed Incorporated | INSM | 343,000 | $5.8M | 0.03% |
| 69 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $5.8M | 0.03% |
| 70 | Natera, Inc. | NTRA | 100,000 | $5.6M | 0.03% |
| 71 | Compass Therapeutics, Inc. | CMPX | 1,557,630 | $5.1M | 0.03% |
| 72 | Affimed N.V. | N01045108 | 6,596,830 | $4.9M | 0.03% |
| 73 | Relay Therapeutics, Inc. | RLAY | 284,000 | $4.7M | 0.03% |
| 74 | Atreca, Inc. | 04965G109 | 3,532,760 | $4.0M | 0.02% |
| 75 | Century Therapeutics, Inc. | IPSC | 1,149,340 | $4.0M | 0.02% |
| 76 | Talis Biomedical Corporation | 87424L108 | 7,624,835 | $3.7M | 0.02% |
| 77 | Design Therapeutics, Inc. | DSGN | 626,884 | $3.6M | 0.02% |
| 78 | Instil Bio, Inc. | TIL | 5,273,789 | $3.5M | 0.02% |
| 79 | Xencor, Inc. | XNCR | 123,127 | $3.4M | 0.02% |
| 80 | Vor Biopharma Inc. | VOR | 633,848 | $3.4M | 0.02% |
| 81 | Edgewise Therapeutics, Inc. | EWTX | 500,000 | $3.3M | 0.02% |
| 82 | Tango Therapeutics, Inc. | TNGX | 750,000 | $3.0M | 0.02% |
| 83 | Monte Rosa Therapeutics, Inc. | GLUE | 375,095 | $2.9M | 0.02% |
| 84 | Neoleukin Therapeutics, Inc. | 64049K104 | 3,821,740 | $2.7M | 0.01% |
| 85 | Vera Therapeutics, Inc. | VERA | 333,333 | $2.6M | 0.01% |
| 86 | HOOKIPA Pharma Inc. | HOOK | 3,475,535 | $2.6M | 0.01% |
| 87 | Leap Therapeutics, Inc. | 52187K101 | 7,425,570 | $2.5M | 0.01% |
| 88 | Achilles Therapeutics plc | 00449L102 | 2,591,366 | $2.5M | 0.01% |
| 89 | Atara Biotherapeutics, Inc. | ATRA | 744,186 | $2.2M | 0.01% |
| 90 | iTeos Therapeutics, Inc. | 46565G104 | 150,346 | $2.0M | 0.01% |
| 91 | Veru Inc. | VERU | 1,609,579 | $1.9M | 0.01% |
| 92 | Vaxcyte, Inc. | PCVX | 48,885 | $1.8M | 0.01% |
| 93 | Aligos Therapeutics, Inc. | ALGS | 2,076,400 | $1.8M | 0.01% |
| 94 | PMV Pharmaceuticals, Inc. | PMVP | 322,024 | $1.5M | 0.01% |
| 95 | Praxis Precision Medicines, Inc. | PRAX | 1,879,915 | $1.5M | 0.01% |
| 96 | Nkarta, Inc. | NKTX | 400,000 | $1.4M | 0.01% |
| 97 | Kala Pharmaceuticals, Inc. | KALA | 76,813 | $1.2M | 0.01% |
| 98 | TCR2 Therapeutics Inc. | 87808K106 | 753,064 | $1.1M | 0.01% |
| 99 | Aeglea BioTherapeutics, Inc. | 00773J103 | 3,410,106 | $988,931 | 0.01% |
| 100 | Protara Therapeutics, Inc. | TARA | 199,671 | $624,970 | 0.00% |
| 101 | Genetron Holdings Limited | 37186H100 | 455,306 | $478,071 | 0.00% |
| 102 | Foghorn Therapeutics Inc. | FHTX | 45,027 | $279,167 | 0.00% |
| 103 | Vincerx Pharma, Inc. | VNCE | 241,379 | $251,034 | 0.00% |
| 104 | Surrozen, Inc. | SRZNW | 833,333 | $83,333 | 0.00% |
| 105 | Bellicum Pharmaceuticals, Inc. | 079481404 | 249,123 | $82,211 | 0.00% |