13F HOLDINGS REPORT
Tekla Capital Management LLC
Quarter ended Q2 2023 · Filed May 10, 2023 · Accession 0001104659-23-057966
Total Value
$2.63B
Positions
177
Other Managers
0
Confidential Omitted
No
Holdings (177)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Amgen Inc. | AMGN | 555,939 | $134.4M | 5.12% |
| 2 | Gilead Sciences, Inc. | GILD | 1,559,884 | $129.4M | 4.93% |
| 3 | Regeneron Pharmaceuticals, Inc. | REGN | 143,053 | $117.5M | 4.48% |
| 4 | Johnson & Johnson | JNJ | 721,779 | $111.9M | 4.26% |
| 5 | Unitedhealth Group Inc. | UNH | 234,173 | $110.7M | 4.21% |
| 6 | Vertex Pharmaceuticals Inc. | VRTX | 330,343 | $104.1M | 3.96% |
| 7 | Eli Lilly and Company | LLY | 288,917 | $99.2M | 3.78% |
| 8 | AbbVie Inc. | ABBV | 511,599 | $81.5M | 3.10% |
| 9 | Illumina, Inc. | ILMN | 348,079 | $80.9M | 3.08% |
| 10 | Pfizer Inc. | PFE | 1,775,076 | $72.4M | 2.76% |
| 11 | AstraZeneca PLC | AZN | 992,664 | $68.9M | 2.62% |
| 12 | Biogen Inc. | BIIB | 240,926 | $67.0M | 2.55% |
| 13 | Abbott Laboratories | ABLZF | 623,855 | $63.2M | 2.41% |
| 14 | Merck & Co., Inc. | MRK | 552,122 | $58.7M | 2.24% |
| 15 | Thermo Fisher Scientific Inc. | TMO | 93,705 | $54.0M | 2.06% |
| 16 | Elevance Health, Inc. | ELV | 114,070 | $52.5M | 2.00% |
| 17 | Moderna, Inc. | MRNA | 322,217 | $49.5M | 1.88% |
| 18 | The Cigna Group | 125523100 | 182,631 | $46.7M | 1.78% |
| 19 | Bristol-Myers Squibb Company | CELG-RI | 663,796 | $46.0M | 1.75% |
| 20 | Seagen Inc. | SE | 224,663 | $45.5M | 1.73% |
| 21 | Sarepta Therapeutics, Inc. | SRPT | 285,653 | $39.4M | 1.50% |
| 22 | argenx SE | ARGX | 88,310 | $32.9M | 1.25% |
| 23 | IDEXX Laboratories, Inc. | 45168D104 | 58,595 | $29.3M | 1.12% |
| 24 | BioMarin Pharmaceutical Inc. | BMRN | 300,089 | $29.2M | 1.11% |
| 25 | Intuitive Surgical, Inc. | ISRG | 112,680 | $28.8M | 1.10% |
| 26 | Alnylam Pharmaceuticals, Inc. | ALNY | 143,214 | $28.7M | 1.09% |
| 27 | Boston Scientific Corp. | BSX | 565,990 | $28.3M | 1.08% |
| 28 | Medtronic plc | MDT | 344,517 | $27.8M | 1.06% |
| 29 | Danaher Corp. | 235851102 | 105,690 | $26.6M | 1.01% |
| 30 | Dexcom, Inc. | DXCM | 228,747 | $26.6M | 1.01% |
| 31 | Charles River Laboratories International, Inc. | 159864107 | 118,083 | $23.8M | 0.91% |
| 32 | McKesson Corp. | MCK | 66,455 | $23.7M | 0.90% |
| 33 | HCA Healthcare, Inc. | HCA | 88,703 | $23.4M | 0.89% |
| 34 | Zoetis Inc. | ZTS | 136,914 | $22.8M | 0.87% |
| 35 | Jazz Pharmaceuticals plc | JAZZ | 147,779 | $21.6M | 0.82% |
| 36 | Stryker Corp. | SYK | 71,578 | $20.4M | 0.78% |
| 37 | Humana Inc. | HUM | 36,794 | $17.9M | 0.68% |
| 38 | Novo Nordisk A/S | NONOF | 111,323 | $17.7M | 0.67% |
| 39 | Molina Healthcare, Inc. | MOH | 61,856 | $16.5M | 0.63% |
| 40 | ResMed Inc. | RSMDF | 73,189 | $16.0M | 0.61% |
| 41 | Edwards Lifesciences Corp. | EW | 171,146 | $14.2M | 0.54% |
| 42 | Exelixis, Inc. | EXEL | 726,639 | $14.1M | 0.54% |
| 43 | United Therapeutics Corp. | UTHR | 61,200 | $13.7M | 0.52% |
| 44 | Acadia Healthcare Company, Inc. | ACHC | 186,487 | $13.5M | 0.51% |
| 45 | Ascendis Pharma A/S | ASND | 123,791 | $13.3M | 0.51% |
| 46 | uniQure N.V. | QURE | 652,446 | $13.1M | 0.50% |
| 47 | Physicians Realty Trust | 71943U104 | 873,655 | $13.0M | 0.50% |
| 48 | BioNTech SE | BNTX | 103,858 | $12.9M | 0.49% |
| 49 | IQVIA Holdings Inc. | IQV | 63,117 | $12.6M | 0.48% |
| 50 | Novartis AG | NVSEF | 136,225 | $12.5M | 0.48% |
| 51 | Neurocrine Biosciences, Inc. | NBIX | 112,908 | $11.4M | 0.44% |
| 52 | SPDR S&P Biotech ETF | 78464A870 | 147,677 | $11.3M | 0.43% |
| 53 | Guardant Health, Inc. | GH | 472,184 | $11.1M | 0.42% |
| 54 | Oculis Holding AG | OCSAW | 1,690,741 | $11.0M | 0.42% |
| 55 | Rallybio Corporation | RLYB | 1,727,067 | $9.9M | 0.38% |
| 56 | Avantor, Inc. | AVTR | 459,488 | $9.7M | 0.37% |
| 57 | Karuna Therapeutics, Inc. | 48576A100 | 53,452 | $9.7M | 0.37% |
| 58 | Travere Therapeutics, Inc. | TVTX | 418,520 | $9.4M | 0.36% |
| 59 | Intra-Cellular Therapies, Inc. | 46116X101 | 172,371 | $9.3M | 0.36% |
| 60 | Laboratory Corporation of America Holdings | 50540R409 | 40,042 | $9.2M | 0.35% |
| 61 | Apellis Pharmaceuticals, Inc. | APLS | 135,124 | $8.9M | 0.34% |
| 62 | Alkermes plc | ALKS | 309,613 | $8.7M | 0.33% |
| 63 | Zimmer Biomet Holdings, Inc. | ZBH | 67,356 | $8.7M | 0.33% |
| 64 | Omega Healthcare Investors, Inc. | 681936100 | 306,433 | $8.4M | 0.32% |
| 65 | Cytokinetics, Inc. | CYTK | 219,025 | $7.7M | 0.29% |
| 66 | Denali Therapeutics, Inc. | DNLI | 324,829 | $7.5M | 0.28% |
| 67 | CVS Health Corp. | CVS | 93,621 | $7.0M | 0.26% |
| 68 | Sanofi | SNYNF | 123,454 | $6.7M | 0.26% |
| 69 | Lantheus Holdings, Inc. | LNTH | 79,495 | $6.6M | 0.25% |
| 70 | LTC Properties, Inc. | 502175102 | 182,293 | $6.4M | 0.24% |
| 71 | Agilent Technologies, Inc. | A | 43,191 | $6.0M | 0.23% |
| 72 | STERIS plc | STE | 31,072 | $5.9M | 0.23% |
| 73 | Sabra Health Care REIT, Inc. | SBRA | 510,660 | $5.9M | 0.22% |
| 74 | VectivBio Holding AG | H9060V101 | 682,834 | $5.9M | 0.22% |
| 75 | Intellia Therapeutics, Inc. | NTLA | 154,269 | $5.7M | 0.22% |
| 76 | Veradigm, Inc. | 01988P108 | 428,580 | $5.6M | 0.21% |
| 77 | Prometheus Biosciences, Inc. | 74349U108 | 50,538 | $5.4M | 0.21% |
| 78 | R1 RCM Inc. | 77634L105 | 356,851 | $5.4M | 0.20% |
| 79 | West Pharmaceutical Services, Inc. | 955306105 | 15,036 | $5.2M | 0.20% |
| 80 | Smith & Nephew plc | SNNUF | 181,710 | $5.1M | 0.19% |
| 81 | Amedisys, Inc. | 023436108 | 68,949 | $5.1M | 0.19% |
| 82 | Addus HomeCare Corp. | ADUS | 42,380 | $4.5M | 0.17% |
| 83 | BeiGene, Ltd. | BEIGF | 20,952 | $4.5M | 0.17% |
| 84 | Cerevel Therapeutics Holdings, Inc. | 15678U128 | 176,483 | $4.3M | 0.16% |
| 85 | BioCryst Pharmaceuticals, Inc. | BCRX | 504,528 | $4.2M | 0.16% |
| 86 | Teva Pharmaceutical Industries Ltd. | 881624209 | 459,651 | $4.1M | 0.15% |
| 87 | Adaptive Biotechnologies Corp. | ADTI | 422,281 | $3.7M | 0.14% |
| 88 | Cardiovascular Systems, Inc. | 141619106 | 174,859 | $3.5M | 0.13% |
| 89 | Kura Oncology, Inc. | KURA | 283,281 | $3.5M | 0.13% |
| 90 | Medical Properties Trust, Inc. | 58463J304 | 411,743 | $3.4M | 0.13% |
| 91 | Healthcare Realty Trust Inc. | 42226K105 | 174,686 | $3.4M | 0.13% |
| 92 | Healthpeak Properties, Inc. | DOC | 150,392 | $3.3M | 0.13% |
| 93 | Amerisourcebergen Corp. | COR | 20,417 | $3.3M | 0.12% |
| 94 | Catalent, Inc. | 148806102 | 49,406 | $3.2M | 0.12% |
| 95 | Ishares Biothechnology ETF | 464287556 | 24,569 | $3.2M | 0.12% |
| 96 | Marinus Pharmaceuticals, Inc. | 56854Q200 | 456,780 | $3.2M | 0.12% |
| 97 | Ionis Pharmaceuticals, Inc. | IONS | 87,840 | $3.1M | 0.12% |
| 98 | Blueprint Medicines Corp. | 09627Y109 | 67,710 | $3.0M | 0.12% |
| 99 | Madrigal Pharmaceuticals, Inc. | MDGL | 12,481 | $3.0M | 0.12% |
| 100 | Caribou Biosciences, Inc. | CRBU | 567,147 | $3.0M | 0.11% |
| 101 | Xenon Pharmaceuticals Inc. | XENE | 83,714 | $3.0M | 0.11% |
| 102 | Welltower Inc. | WELL | 41,484 | $3.0M | 0.11% |
| 103 | Ventas, Inc. | VTR | 66,681 | $2.9M | 0.11% |
| 104 | Pyxis Oncology, Inc. | PYXS | 708,303 | $2.8M | 0.11% |
| 105 | LivaNova plc | LIVN | 63,880 | $2.8M | 0.11% |
| 106 | Natera, Inc. | NTRA | 49,272 | $2.7M | 0.10% |
| 107 | Baxter International, Inc. | 071813109 | 67,312 | $2.7M | 0.10% |
| 108 | Ultragenyx Pharmaceutical Inc. | RARE | 67,065 | $2.7M | 0.10% |
| 109 | Assertio Holdings, Inc. | ASRT | 410,575 | $2.6M | 0.10% |
| 110 | Ardelyx, Inc. | ARDX | 539,408 | $2.6M | 0.10% |
| 111 | Arrowhead Pharmaceuticals, Inc. | ARWR | 100,422 | $2.6M | 0.10% |
| 112 | Bridgebio Pharma, Inc. | BBIO | 150,921 | $2.5M | 0.10% |
| 113 | CRISPR Therapeutics AG | CRSP | 55,080 | $2.5M | 0.09% |
| 114 | Syndax Pharmaceuticals, Inc. | SNDX | 117,717 | $2.5M | 0.09% |
| 115 | Mirati Therapeutics, Inc. | 60468T105 | 65,490 | $2.4M | 0.09% |
| 116 | Align Technology, Inc. | ALGN | 6,925 | $2.3M | 0.09% |
| 117 | Galera Therapeutics, Inc. | GRTX | 898,374 | $2.3M | 0.09% |
| 118 | Option Care Health, Inc. | OPCH | 64,975 | $2.1M | 0.08% |
| 119 | Koninklijke Philips N.V. | RYLPF | 109,860 | $2.0M | 0.08% |
| 120 | Icon plc | ICLR | 9,334 | $2.0M | 0.08% |
| 121 | Chinook Therapeutics, Inc. | 16961L106 | 83,500 | $1.9M | 0.07% |
| 122 | Bicycle Therapeutics PLC | BCYC | 88,676 | $1.9M | 0.07% |
| 123 | Perrigo Company plc | PRGO | 51,224 | $1.8M | 0.07% |
| 124 | Immunovant, Inc. | IMVT | 115,400 | $1.8M | 0.07% |
| 125 | Medpace Holdings, Inc. | MEDP | 9,435 | $1.8M | 0.07% |
| 126 | Takeda Pharmaceutical Company Ltd. | TKPHF | 105,073 | $1.7M | 0.07% |
| 127 | Arcutis Biotherapeutics, Inc. | ARQT | 148,874 | $1.6M | 0.06% |
| 128 | Reata Pharmaceuticals, Inc. Class A | 75615P103 | 17,850 | $1.6M | 0.06% |
| 129 | 89bio, Inc. | 282559103 | 105,898 | $1.6M | 0.06% |
| 130 | Global Medical REIT Inc. | 37954A204 | 174,897 | $1.6M | 0.06% |
| 131 | GSK plc | GLAXF | 41,852 | $1.5M | 0.06% |
| 132 | Edgewise Therapeutics, Inc. | EWTX | 195,025 | $1.3M | 0.05% |
| 133 | Merus N.V. | N5749R100 | 69,025 | $1.3M | 0.05% |
| 134 | Crinetics Pharmaceuticals, Inc. | CRNX | 78,529 | $1.3M | 0.05% |
| 135 | Zai Lab Ltd. | ZLAB | 34,640 | $1.2M | 0.04% |
| 136 | G1 Therapeutics, Inc. | 3621LQ109 | 423,869 | $1.1M | 0.04% |
| 137 | Mereo BioPharma Group plc | MREO | 1,551,082 | $1.1M | 0.04% |
| 138 | Scholar Rock Holding Corp. | SRRK | 108,833 | $870,664 | 0.03% |
| 139 | Intercept Pharmaceuticals, Inc. | INTR | 52,067 | $699,260 | 0.03% |
| 140 | Mersana Therapeutics, Inc. | 59045L106 | 162,383 | $667,394 | 0.03% |
| 141 | Theseus Pharmaceuticals, Inc. | 88369M101 | 75,000 | $666,000 | 0.03% |
| 142 | iTeos Therapeutics, Inc. | 46565G104 | 45,735 | $622,453 | 0.02% |
| 143 | Arcus Biosciences, Inc. | RCUS | 32,839 | $598,983 | 0.02% |
| 144 | Tactile Systems Technology, Inc. | 87357P100 | 34,432 | $565,373 | 0.02% |
| 145 | I-Mab | NBP | 162,580 | $562,527 | 0.02% |
| 146 | Community Healthcare Trust Inc. | CHCT | 14,900 | $545,340 | 0.02% |
| 147 | Universal Health Realty Income Trust | 91359E105 | 11,258 | $541,622 | 0.02% |
| 148 | National Health Investors, Inc. | 63633D104 | 10,038 | $517,760 | 0.02% |
| 149 | Beam Therapeutics Inc. | BEAM | 15,817 | $484,317 | 0.02% |
| 150 | Diversified Healthcare Trust | DHCNL | 357,720 | $482,922 | 0.02% |
| 151 | Biohaven Ltd. | BHVN | 35,087 | $479,288 | 0.02% |
| 152 | Sutro Biopharma, Inc. | STRO | 98,354 | $454,395 | 0.02% |
| 153 | Novavax, Inc. | NVAX | 63,800 | $442,134 | 0.02% |
| 154 | Affimed N.V. | N01045108 | 586,038 | $436,950 | 0.02% |
| 155 | Community Health Systems, Inc. | 203668108 | 88,335 | $432,842 | 0.02% |
| 156 | TScan Therapeutics, Inc. | TCRX | 200,000 | $420,000 | 0.02% |
| 157 | MorphoSys AG | 617760202 | 81,867 | $323,375 | 0.01% |
| 158 | Altimmune, Inc. | ALT | 75,000 | $316,500 | 0.01% |
| 159 | ALX Oncology Holdings Inc. | ALXO | 66,211 | $299,274 | 0.01% |
| 160 | Repare Therapeutics Inc. | 760273102 | 29,150 | $286,836 | 0.01% |
| 161 | Codexis Inc | CDXS | 69,125 | $286,178 | 0.01% |
| 162 | Mallinckrodt plc | G5890A102 | 35,048 | $255,503 | 0.01% |
| 163 | Black Diamond Therapeutics, Inc. | BDTX | 131,990 | $249,461 | 0.01% |
| 164 | Adicet Bio, Inc. | ACET | 40,329 | $232,295 | 0.01% |
| 165 | Harpoon Therapeutics, Inc. | 41358P106 | 259,910 | $193,425 | 0.01% |
| 166 | Vaxcyte, Inc. | PCVX | 5,000 | $187,400 | 0.01% |
| 167 | Precision BioSciences, Inc. | DTIL | 224,534 | $169,209 | 0.01% |
| 168 | Fulcrum Therapeutics, Inc. | FULC | 58,537 | $166,830 | 0.01% |
| 169 | Fusion Pharmaceuticals Inc. | 36118A100 | 43,394 | $163,595 | 0.01% |
| 170 | Nkarta, Inc. | NKTX | 28,988 | $102,907 | 0.00% |
| 171 | Spectrum Pharmaceuticals, Inc. | 84763A108 | 114,670 | $86,003 | 0.00% |
| 172 | ARCA biopharma, Inc. | 00211Y506 | 32,461 | $64,597 | 0.00% |
| 173 | Praxis Precision Medicines, Inc. | PRAX | 75,000 | $60,675 | 0.00% |
| 174 | Corbus Pharmaceuticals Holdings, Inc. | CRBP | 5,143 | $37,390 | 0.00% |
| 175 | VYNE Therapeutics, Inc. | VYNE | 7,520 | $23,162 | 0.00% |
| 176 | NexGel, Inc. | NXGLW | 4,243 | $5,516 | 0.00% |
| 177 | Bellicum Pharmaceuticals, Inc. | 079481404 | 6,000 | $1,980 | 0.00% |