13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q1 2023 · Filed February 14, 2023 · Accession 0001104659-23-021551
Total Value
$16.65B
Positions
113
Other Managers
0
Confidential Omitted
No
Holdings (113)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Seagen Inc. | SE | 46,912,266 | $6.03B | 36.21% |
| 2 | Incyte Corporation | INCY | 36,154,971 | $2.90B | 17.44% |
| 3 | BeiGene, Ltd. | BEIGF | 11,668,897 | $2.57B | 15.41% |
| 4 | BioMarin Pharmaceutical Inc. | BMRN | 7,620,494 | $788.6M | 4.74% |
| 5 | ACADIA Pharmaceuticals Inc. | ACAD | 41,923,486 | $667.4M | 4.01% |
| 6 | Ascendis Pharma A/S | ASND | 4,954,855 | $605.1M | 3.63% |
| 7 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,545,113 | $448.5M | 2.69% |
| 8 | Rhythm Pharmaceuticals, Inc. | RYTM | 6,354,608 | $185.0M | 1.11% |
| 9 | BioCryst Pharmaceuticals, Inc. | BCRX | 12,710,818 | $145.9M | 0.88% |
| 10 | Immunocore Holdings plc | IMCR | 2,520,731 | $143.9M | 0.86% |
| 11 | Akero Therapeutics, Inc. | 00973Y108 | 2,368,378 | $129.8M | 0.78% |
| 12 | Replimune Group, Inc. | REPL | 4,578,280 | $124.5M | 0.75% |
| 13 | Kodiak Sciences Inc. | KOD | 17,310,490 | $123.9M | 0.74% |
| 14 | Horizon Therapeutics Public Ltd Co | G46188101 | 969,727 | $110.4M | 0.66% |
| 15 | argenx SE | ARGX | 280,159 | $106.1M | 0.64% |
| 16 | AbCellera Biologics Inc. | ABCL | 10,450,180 | $105.9M | 0.64% |
| 17 | Kymera Therapeutics, Inc. | KYMR | 2,879,825 | $71.9M | 0.43% |
| 18 | Chinook Therapeutics, Inc. | 16961L106 | 2,534,102 | $66.4M | 0.40% |
| 19 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $65.8M | 0.40% |
| 20 | Mirati Therapeutics, Inc. | 60468T105 | 1,409,784 | $63.9M | 0.38% |
| 21 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $61.1M | 0.37% |
| 22 | Cerus Corporation | CERS | 16,067,558 | $58.6M | 0.35% |
| 23 | Aerovate Therapeutics, Inc. | 008064107 | 1,976,868 | $57.9M | 0.35% |
| 24 | IGM Biosciences, Inc. | 449585108 | 3,156,102 | $53.7M | 0.32% |
| 25 | Immatics N.V. | IMTX | 5,187,081 | $45.2M | 0.27% |
| 26 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $42.6M | 0.26% |
| 27 | Kiniksa Pharmaceuticals, Ltd. | KNSA | 2,799,577 | $41.9M | 0.25% |
| 28 | SpringWorks Therapeutics, Inc. | 85205L107 | 1,528,538 | $39.8M | 0.24% |
| 29 | IDEAYA Biosciences, Inc. | IDYA | 1,668,355 | $30.3M | 0.18% |
| 30 | Denali Therapeutics Inc. | DNLI | 1,088,738 | $30.3M | 0.18% |
| 31 | Xenon Pharmaceuticals Inc. | XENE | 751,639 | $29.6M | 0.18% |
| 32 | Verve Therapeutics, Inc. | 92539P101 | 1,416,530 | $27.4M | 0.16% |
| 33 | DICE Therapeutics, Inc. | 23345J104 | 862,207 | $26.9M | 0.16% |
| 34 | Travere Therapeutics, Inc. | TVTX | 1,225,255 | $25.8M | 0.15% |
| 35 | Bicycle Therapeutics plc | BCYC | 843,814 | $25.0M | 0.15% |
| 36 | AnaptysBio, Inc. | ANABV | 775,924 | $24.0M | 0.14% |
| 37 | Krystal Biotech, Inc. | KRYS | 302,716 | $24.0M | 0.14% |
| 38 | DBV Technologies S.A. | DBVTF | 14,614,264 | $22.4M | 0.13% |
| 39 | FibroGen, Inc. | 31572Q808 | 1,375,211 | $22.0M | 0.13% |
| 40 | Ultragenyx Pharmaceutical Inc. | RARE | 470,974 | $21.8M | 0.13% |
| 41 | Heron Therapeutics, Inc. | HRTX | 8,131,678 | $20.3M | 0.12% |
| 42 | 2seventy bio, Inc. | 901384107 | 2,062,744 | $19.3M | 0.12% |
| 43 | Insmed Incorporated | INSM | 23,500,000 | $19.2M | 0.12% |
| 44 | Prime Medicine, Inc. | PRME | 1,028,466 | $19.1M | 0.11% |
| 45 | Biomea Fusion, Inc. | BMEA | 2,104,559 | $17.7M | 0.11% |
| 46 | bluebird bio, Inc. | 09609G100 | 2,499,715 | $17.3M | 0.10% |
| 47 | ARS Pharmaceuticals, Inc. | SPRY | 2,006,451 | $17.1M | 0.10% |
| 48 | Invitae Corporation | 46185L103 | 8,402,035 | $15.6M | 0.09% |
| 49 | Opthea Limited | OPTEY | 2,691,391 | $14.4M | 0.09% |
| 50 | Adaptimmune Therapeutics plc | ADTI | 9,830,877 | $14.4M | 0.09% |
| 51 | CymaBay Therapeutics, Inc. | 23257D103 | 2,170,464 | $13.6M | 0.08% |
| 52 | Zymeworks Inc. | ZYME | 1,708,472 | $13.4M | 0.08% |
| 53 | Aadi Bioscience, Inc. | WHWK | 989,928 | $12.7M | 0.08% |
| 54 | Cabaletta Bio, Inc. | CABA | 1,344,000 | $12.4M | 0.07% |
| 55 | Verastem, Inc. | VSTM | 26,988,898 | $10.9M | 0.07% |
| 56 | Altimmune, Inc. | ALT | 653,562 | $10.8M | 0.06% |
| 57 | Stoke Therapeutics, Inc. | STOK | 1,108,913 | $10.2M | 0.06% |
| 58 | CinCor Pharma, Inc. | 17240Y109 | 807,212 | $9.9M | 0.06% |
| 59 | Vor Biopharma Inc. | VOR | 1,465,925 | $9.7M | 0.06% |
| 60 | Avidity Biosciences, Inc. | 05370A108 | 434,782 | $9.6M | 0.06% |
| 61 | Pacific Biosciences of California, Inc. | 69404D108 | 1,127,782 | $9.2M | 0.06% |
| 62 | POINT Biopharma Global Inc. | 730541109 | 1,169,103 | $8.5M | 0.05% |
| 63 | Reata Pharmaceuticals, Inc. | 75615P103 | 223,976 | $8.5M | 0.05% |
| 64 | Summit Therapeutics Inc. | SMMT | 2,000,000 | $8.5M | 0.05% |
| 65 | Veru Inc. | VERU | 1,609,579 | $8.5M | 0.05% |
| 66 | Affimed N.V. | N01045108 | 6,596,830 | $8.2M | 0.05% |
| 67 | Invitae Corporation | 46185LAB9 | 10,300,000 | $8.1M | 0.05% |
| 68 | Compass Therapeutics, Inc. | CMPX | 1,557,630 | $7.8M | 0.05% |
| 69 | Design Therapeutics, Inc. | DSGN | 692,131 | $7.1M | 0.04% |
| 70 | Biohaven Ltd. | BHVN | 476,190 | $6.6M | 0.04% |
| 71 | Vera Therapeutics, Inc. | VERA | 333,333 | $6.4M | 0.04% |
| 72 | Alector, Inc. | ALEC | 681,991 | $6.3M | 0.04% |
| 73 | MacroGenics, Inc. | MGNX | 892,579 | $6.0M | 0.04% |
| 74 | Athira Pharma, Inc. | 04746L104 | 1,879,836 | $6.0M | 0.04% |
| 75 | Century Therapeutics, Inc. | IPSC | 1,149,340 | $5.9M | 0.04% |
| 76 | Roivant Sciences Ltd. | ROIV | 716,653 | $5.7M | 0.03% |
| 77 | Tango Therapeutics, Inc. | TNGX | 750,000 | $5.4M | 0.03% |
| 78 | Revolution Medicines, Inc. | RVMDW | 222,222 | $5.3M | 0.03% |
| 79 | Edgewise Therapeutics, Inc. | EWTX | 500,000 | $4.5M | 0.03% |
| 80 | Praxis Precision Medicines, Inc. | PRAX | 1,830,315 | $4.4M | 0.03% |
| 81 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $4.3M | 0.03% |
| 82 | Aravive, Inc. | 03890D108 | 3,261,224 | $4.3M | 0.03% |
| 83 | Cyteir Therapeutics, Inc. | 23284P103 | 2,492,118 | $4.1M | 0.02% |
| 84 | Natera, Inc. | NTRA | 100,000 | $4.0M | 0.02% |
| 85 | Talis Biomedical Corporation | 87424L108 | 7,624,835 | $3.4M | 0.02% |
| 86 | Instil Bio, Inc. | TIL | 5,273,789 | $3.3M | 0.02% |
| 87 | Xencor, Inc. | XNCR | 123,127 | $3.2M | 0.02% |
| 88 | iTeos Therapeutics, Inc. | 46565G104 | 150,346 | $2.9M | 0.02% |
| 89 | Kala Pharmaceuticals, Inc. | KALA | 76,813 | $2.9M | 0.02% |
| 90 | Atreca, Inc. | 04965G109 | 3,532,760 | $2.8M | 0.02% |
| 91 | HOOKIPA Pharma Inc. | HOOK | 3,475,535 | $2.8M | 0.02% |
| 92 | PMV Pharmaceuticals, Inc. | PMVP | 322,024 | $2.8M | 0.02% |
| 93 | Atara Biotherapeutics, Inc. | ATRA | 744,186 | $2.4M | 0.01% |
| 94 | Nkarta, Inc. | NKTX | 400,000 | $2.4M | 0.01% |
| 95 | Vaxcyte, Inc. | PCVX | 48,885 | $2.3M | 0.01% |
| 96 | Achilles Therapeutics plc | 00449L102 | 2,591,366 | $2.3M | 0.01% |
| 97 | Fate Therapeutics, Inc. | FATE | 215,695 | $2.2M | 0.01% |
| 98 | Aligos Therapeutics, Inc. | ALGS | 2,076,400 | $2.0M | 0.01% |
| 99 | Neoleukin Therapeutics, Inc. | 64049K104 | 3,821,740 | $1.9M | 0.01% |
| 100 | Kronos Bio, Inc. | 50107A104 | 1,198,151 | $1.9M | 0.01% |
| 101 | Aeglea BioTherapeutics, Inc. | 00773J103 | 3,410,106 | $1.5M | 0.01% |
| 102 | TCR2 Therapeutics Inc. | 87808K106 | 753,064 | $752,160 | 0.00% |
| 103 | Protara Therapeutics, Inc. | TARA | 199,671 | $535,118 | 0.00% |
| 104 | Genetron Holdings Limited | 37186H100 | 455,306 | $509,943 | 0.00% |
| 105 | Kezar Life Sciences, Inc. | KZR | 61,946 | $436,100 | 0.00% |
| 106 | Insmed Incorporated | INSM | 19,950 | $398,601 | 0.00% |
| 107 | Foghorn Therapeutics Inc. | FHTX | 45,027 | $287,272 | 0.00% |
| 108 | Sera Prognostics, Inc. | SERA | 201,562 | $253,968 | 0.00% |
| 109 | Leap Therapeutics, Inc. | 52187K101 | 559,705 | $251,867 | 0.00% |
| 110 | Vincerx Pharma, Inc. | VNCE | 241,379 | $246,207 | 0.00% |
| 111 | Bellicum Pharmaceuticals, Inc. | 079481404 | 249,123 | $179,369 | 0.00% |
| 112 | Surrozen, Inc. | SRZNW | 833,333 | $45,917 | 0.00% |
| 113 | aTyr Pharma, Inc. | ATYR | 8,565 | $18,757 | 0.00% |