13F HOLDINGS REPORT
Tekla Capital Management LLC
Quarter ended Q1 2023 · Filed February 10, 2023 · Accession 0001104659-23-018131
Total Value
$2.65B
Positions
172
Other Managers
0
Confidential Omitted
No
Holdings (172)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Unitedhealth Group Inc. | UNH | 270,546 | $143.4M | 5.42% |
| 2 | Amgen Inc. | AMGN | 508,676 | $133.6M | 5.05% |
| 3 | Gilead Sciences, Inc. | GILD | 1,510,440 | $129.7M | 4.90% |
| 4 | Johnson & Johnson | JNJ | 639,679 | $113.0M | 4.27% |
| 5 | Eli Lilly and Company | LLY | 288,917 | $105.7M | 3.99% |
| 6 | Vertex Pharmaceuticals Inc. | VRTX | 330,343 | $95.4M | 3.60% |
| 7 | Regeneron Pharmaceuticals, Inc. | REGN | 120,862 | $87.2M | 3.29% |
| 8 | AbbVie Inc. | ABBV | 478,342 | $77.3M | 2.92% |
| 9 | Abbott Laboratories | ABLZF | 693,051 | $76.1M | 2.87% |
| 10 | Pfizer Inc. | PFE | 1,457,170 | $74.7M | 2.82% |
| 11 | AstraZeneca PLC | AZN | 1,022,255 | $69.3M | 2.62% |
| 12 | Illumina, Inc. | ILMN | 319,958 | $64.7M | 2.44% |
| 13 | Merck & Co., Inc. | MRK | 552,122 | $61.3M | 2.31% |
| 14 | Cigna Corp. | 125523100 | 182,631 | $60.5M | 2.29% |
| 15 | Biogen Inc. | BIIB | 195,430 | $54.1M | 2.04% |
| 16 | Thermo Fisher Scientific Inc. | TMO | 93,705 | $51.6M | 1.95% |
| 17 | Bristol-Myers Squibb Company | CELG-RI | 687,529 | $49.5M | 1.87% |
| 18 | Moderna, Inc. | MRNA | 264,927 | $47.6M | 1.80% |
| 19 | Horizon Therapeutics plc | G46188101 | 415,053 | $47.2M | 1.78% |
| 20 | Stryker Corp. | SYK | 164,128 | $40.1M | 1.52% |
| 21 | Humana Inc. | HUM | 77,713 | $39.8M | 1.50% |
| 22 | Boston Scientific Corp. | BSX | 757,015 | $35.0M | 1.32% |
| 23 | Alnylam Pharmaceuticals, Inc. | ALNY | 143,214 | $34.0M | 1.29% |
| 24 | Zimmer Biomet Holdings, Inc. | ZBH | 258,868 | $33.0M | 1.25% |
| 25 | United Therapeutics Corp. | UTHR | 115,077 | $32.0M | 1.21% |
| 26 | argenx SE | ARGX | 84,021 | $31.8M | 1.20% |
| 27 | Intuitive Surgical, Inc. | ISRG | 112,680 | $29.9M | 1.13% |
| 28 | Jazz Pharmaceuticals plc | JAZZ | 182,782 | $29.1M | 1.10% |
| 29 | Danaher Corp. | 235851102 | 105,690 | $28.1M | 1.06% |
| 30 | IDEXX Laboratories, Inc. | 45168D104 | 68,065 | $27.8M | 1.05% |
| 31 | Medtronic plc | MDT | 326,172 | $25.4M | 0.96% |
| 32 | HCA Healthcare, Inc. | HCA | 105,003 | $25.2M | 0.95% |
| 33 | McKesson Corp. | MCK | 66,455 | $24.9M | 0.94% |
| 34 | Dexcom, Inc. | DXCM | 218,015 | $24.7M | 0.93% |
| 35 | Molina Healthcare, Inc. | MOH | 73,615 | $24.3M | 0.92% |
| 36 | BioMarin Pharmaceutical Inc. | BMRN | 230,790 | $23.9M | 0.90% |
| 37 | Zoetis Inc. | ZTS | 136,914 | $20.1M | 0.76% |
| 38 | Sarepta Therapeutics, Inc. | SRPT | 140,959 | $18.3M | 0.69% |
| 39 | Novo Nordisk A/S | NONOF | 130,523 | $17.7M | 0.67% |
| 40 | Lantheus Holdings, Inc. | LNTH | 342,872 | $17.5M | 0.66% |
| 41 | Charles River Laboratories International, Inc. | 159864107 | 72,675 | $15.8M | 0.60% |
| 42 | BioNTech SE | BNTX | 103,858 | $15.6M | 0.59% |
| 43 | Ascendis Pharma A/S | ASND | 123,791 | $15.1M | 0.57% |
| 44 | uniQure N.V. | QURE | 652,446 | $14.8M | 0.56% |
| 45 | Seagen Inc. | SE | 112,214 | $14.4M | 0.54% |
| 46 | Neurocrine Biosciences, Inc. | NBIX | 112,908 | $13.5M | 0.51% |
| 47 | IQVIA Holdings Inc. | IQV | 63,117 | $12.9M | 0.49% |
| 48 | Guardant Health, Inc. | GH | 472,184 | $12.8M | 0.49% |
| 49 | Edwards Lifesciences Corp. | EW | 171,388 | $12.8M | 0.48% |
| 50 | ResMed Inc. | RSMDF | 60,699 | $12.6M | 0.48% |
| 51 | Novartis AG | NVSEF | 136,225 | $12.4M | 0.47% |
| 52 | SPDR S&P Biotech ETF | 78464A870 | 147,677 | $12.3M | 0.46% |
| 53 | Acadia Healthcare Company, Inc. | ACHC | 141,189 | $11.6M | 0.44% |
| 54 | Rallybio Corporation | RLYB | 1,727,067 | $11.3M | 0.43% |
| 55 | Align Technology, Inc. | ALGN | 50,824 | $10.7M | 0.40% |
| 56 | Karuna Therapeutics, Inc. | 48576A100 | 53,452 | $10.5M | 0.40% |
| 57 | Laboratory Corporation of America Holdings | 50540R409 | 44,142 | $10.4M | 0.39% |
| 58 | Avantor, Inc. | AVTR | 459,488 | $9.7M | 0.37% |
| 59 | Intra-Cellular Therapies, Inc. | 46116X101 | 172,371 | $9.1M | 0.34% |
| 60 | Travere Therapeutics, Inc. | TVTX | 418,520 | $8.8M | 0.33% |
| 61 | CVS Health Corp. | CVS | 93,621 | $8.7M | 0.33% |
| 62 | Omega Healthcare Investors, Inc. | 681936100 | 306,433 | $8.6M | 0.32% |
| 63 | Alkermes plc | ALKS | 309,613 | $8.1M | 0.31% |
| 64 | BioCryst Pharmaceuticals, Inc. | BCRX | 672,705 | $7.7M | 0.29% |
| 65 | Denali Therapeutics, Inc. | DNLI | 272,520 | $7.6M | 0.29% |
| 66 | Allscripts Healthcare Solutions, Inc. | 01988P108 | 428,580 | $7.6M | 0.29% |
| 67 | Elevance Health, Inc. | ELV | 14,644 | $7.5M | 0.28% |
| 68 | HealthEquity, Inc. | HQY | 110,214 | $6.8M | 0.26% |
| 69 | LTC Properties, Inc. | 502175102 | 182,293 | $6.5M | 0.24% |
| 70 | Agilent Technologies, Inc. | A | 43,191 | $6.5M | 0.24% |
| 71 | VectivBio Holding AG | H9060V101 | 737,704 | $6.4M | 0.24% |
| 72 | Sabra Health Care REIT, Inc. | SBRA | 510,660 | $6.3M | 0.24% |
| 73 | Sanofi | SNYNF | 123,454 | $6.0M | 0.23% |
| 74 | Catalent, Inc. | 148806102 | 125,947 | $5.7M | 0.21% |
| 75 | Cerevel Therapeutics Holdings, Inc. | 15678U128 | 176,483 | $5.6M | 0.21% |
| 76 | Intellia Therapeutics, Inc. | NTLA | 154,269 | $5.4M | 0.20% |
| 77 | Xencor, Inc. | XNCR | 200,328 | $5.2M | 0.20% |
| 78 | Smith & Nephew plc | SNNUF | 181,710 | $4.9M | 0.18% |
| 79 | BeiGene, Ltd. | BEIGF | 20,952 | $4.6M | 0.17% |
| 80 | Medical Properties Trust, Inc. | 58463J304 | 411,743 | $4.6M | 0.17% |
| 81 | Addus HomeCare Corp. | ADUS | 42,380 | $4.2M | 0.16% |
| 82 | Prometheus Biosciences, Inc. | 74349U108 | 38,237 | $4.2M | 0.16% |
| 83 | Teva Pharmaceutical Industries Ltd. | 881624209 | 459,651 | $4.2M | 0.16% |
| 84 | Arrowhead Pharmaceuticals, Inc. | ARWR | 100,422 | $4.1M | 0.15% |
| 85 | Healthpeak Properties, Inc. | DOC | 150,392 | $3.8M | 0.14% |
| 86 | Caribou Biosciences, Inc. | CRBU | 567,147 | $3.6M | 0.13% |
| 87 | Kura Oncology, Inc. | KURA | 283,281 | $3.5M | 0.13% |
| 88 | Cytokinetics, Inc. | CYTK | 75,139 | $3.4M | 0.13% |
| 89 | Apellis Pharmaceuticals, Inc. | APLS | 66,426 | $3.4M | 0.13% |
| 90 | Amerisourcebergen Corp. | COR | 20,417 | $3.4M | 0.13% |
| 91 | Healthcare Realty Trust Inc. | 42226K105 | 174,686 | $3.4M | 0.13% |
| 92 | Ionis Pharmaceuticals, Inc. | IONS | 87,840 | $3.3M | 0.13% |
| 93 | Xenon Pharmaceuticals Inc. | XENE | 83,714 | $3.3M | 0.12% |
| 94 | Adaptive Biotechnologies Corp. | ADTI | 422,281 | $3.2M | 0.12% |
| 95 | Ishares Biothechnology ETF | 464287556 | 24,569 | $3.2M | 0.12% |
| 96 | MoonLake Immunotherapeutics AG | MLTX | 300,000 | $3.1M | 0.12% |
| 97 | Ultragenyx Pharmaceutical Inc. | RARE | 67,065 | $3.1M | 0.12% |
| 98 | STERIS plc | STE | 16,669 | $3.1M | 0.12% |
| 99 | Ventas, Inc. | VTR | 66,681 | $3.0M | 0.11% |
| 100 | Syndax Pharmaceuticals, Inc. | SNDX | 117,717 | $3.0M | 0.11% |
| 101 | Mirati Therapeutics, Inc. | 60468T105 | 65,490 | $3.0M | 0.11% |
| 102 | Blueprint Medicines Corp. | 09627Y109 | 67,710 | $3.0M | 0.11% |
| 103 | Welltower Inc. | WELL | 41,484 | $2.7M | 0.10% |
| 104 | Bicycle Therapeutics PLC | BCYC | 88,676 | $2.6M | 0.10% |
| 105 | Physicians Realty Trust | 71943U104 | 168,741 | $2.4M | 0.09% |
| 106 | IDEAYA Biosciences, Inc. | IDYA | 133,185 | $2.4M | 0.09% |
| 107 | Cardiovascular Systems, Inc. | 141619106 | 174,859 | $2.4M | 0.09% |
| 108 | G1 Therapeutics, Inc. | 3621LQ109 | 423,869 | $2.3M | 0.09% |
| 109 | CRISPR Therapeutics AG | CRSP | 55,080 | $2.2M | 0.08% |
| 110 | R1 RCM Inc. | 77634L105 | 202,351 | $2.2M | 0.08% |
| 111 | Arcutis Biotherapeutics, Inc. | ARQT | 148,874 | $2.2M | 0.08% |
| 112 | Medpace Holdings, Inc. | MEDP | 9,435 | $2.0M | 0.08% |
| 113 | Natera, Inc. | NTRA | 49,272 | $2.0M | 0.07% |
| 114 | Option Care Health, Inc. | OPCH | 64,975 | $2.0M | 0.07% |
| 115 | Icon plc | ICLR | 9,334 | $1.8M | 0.07% |
| 116 | Assertio Holdings, Inc. | ASRT | 410,575 | $1.8M | 0.07% |
| 117 | Perrigo Company plc | PRGO | 51,224 | $1.7M | 0.07% |
| 118 | Edgewise Therapeutics, Inc. | EWTX | 195,025 | $1.7M | 0.07% |
| 119 | Global Medical REIT Inc. | 37954A204 | 174,897 | $1.7M | 0.06% |
| 120 | Koninklijke Philips N.V. | RYLPF | 109,860 | $1.6M | 0.06% |
| 121 | Takeda Pharmaceutical Company Ltd. | TKPHF | 105,073 | $1.6M | 0.06% |
| 122 | Ardelyx, Inc. | ARDX | 539,408 | $1.5M | 0.06% |
| 123 | Arvinas, Inc. | ARVN | 42,998 | $1.5M | 0.06% |
| 124 | GSK plc ADR | GLAXF | 41,852 | $1.5M | 0.06% |
| 125 | Merus N.V. | N5749R100 | 92,325 | $1.4M | 0.05% |
| 126 | Galera Therapeutics, Inc. | GRTX | 898,374 | $1.3M | 0.05% |
| 127 | Protagonist Therapeutics, Inc. | PTGX | 122,271 | $1.3M | 0.05% |
| 128 | Zai Lab Ltd. | ZLAB | 43,300 | $1.3M | 0.05% |
| 129 | Stevanato Group Societa' Per Azioni | STVN | 71,190 | $1.3M | 0.05% |
| 130 | Morphic Holding, Inc. | 61775R105 | 44,625 | $1.2M | 0.05% |
| 131 | Sutro Biopharma, Inc. | STRO | 147,531 | $1.2M | 0.05% |
| 132 | Mereo BioPharma Group plc | MREO | 1,551,082 | $1.2M | 0.04% |
| 133 | ACADIA Pharmaceuticals Inc. | ACAD | 72,225 | $1.1M | 0.04% |
| 134 | Scholar Rock Holding Corp. | SRRK | 108,833 | $984,939 | 0.04% |
| 135 | Pyxis Oncology, Inc. | PYXS | 708,303 | $949,126 | 0.04% |
| 136 | Crinetics Pharmaceuticals, Inc. | CRNX | 45,861 | $839,256 | 0.03% |
| 137 | ALX Oncology Holdings Inc. | ALXO | 66,211 | $746,198 | 0.03% |
| 138 | Affimed N.V. | N01045108 | 586,038 | $726,687 | 0.03% |
| 139 | Pliant Therapeutics, Inc. | PLRX | 35,233 | $681,054 | 0.03% |
| 140 | I-Mab | NBP | 162,580 | $679,584 | 0.03% |
| 141 | Novavax, Inc. | NVAX | 63,800 | $655,864 | 0.02% |
| 142 | Intercept Pharmaceuticals, Inc. | INTR | 52,067 | $644,069 | 0.02% |
| 143 | Beam Therapeutics Inc. | BEAM | 15,817 | $618,603 | 0.02% |
| 144 | Universal Health Realty Income Trust | 91359E105 | 11,258 | $537,344 | 0.02% |
| 145 | Community Healthcare Trust Inc. | CHCT | 14,900 | $533,420 | 0.02% |
| 146 | National Health Investors, Inc. | 63633D104 | 10,038 | $524,184 | 0.02% |
| 147 | 1Life Healthcare, Inc. | 68269G107 | 31,266 | $522,455 | 0.02% |
| 148 | Theseus Pharmaceuticals, Inc. | 88369M101 | 100,000 | $498,000 | 0.02% |
| 149 | Biohaven Ltd. | BHVN | 35,087 | $487,008 | 0.02% |
| 150 | Repare Therapeutics Inc. | 760273102 | 29,150 | $428,797 | 0.02% |
| 151 | Fulcrum Therapeutics, Inc. | FULC | 58,537 | $426,149 | 0.02% |
| 152 | Community Health Systems, Inc. | 203668108 | 88,335 | $381,607 | 0.01% |
| 153 | Adicet Bio, Inc. | ACET | 40,329 | $360,541 | 0.01% |
| 154 | TScan Therapeutics, Inc. | TCRX | 200,000 | $326,000 | 0.01% |
| 155 | Codexis Inc | CDXS | 69,125 | $322,123 | 0.01% |
| 156 | MorphoSys AG | 617760202 | 81,867 | $293,084 | 0.01% |
| 157 | Mallinckrodt plc | G5890A102 | 35,048 | $271,622 | 0.01% |
| 158 | Precision BioSciences, Inc. | DTIL | 224,534 | $267,195 | 0.01% |
| 159 | Vaxcyte, Inc. | PCVX | 5,000 | $239,750 | 0.01% |
| 160 | Black Diamond Therapeutics, Inc. | BDTX | 131,990 | $237,582 | 0.01% |
| 161 | Diversified Healthcare Trust | DHCNL | 357,720 | $231,373 | 0.01% |
| 162 | Harpoon Therapeutics, Inc. | 41358P106 | 259,910 | $188,617 | 0.01% |
| 163 | Praxis Precision Medicines, Inc. | PRAX | 75,000 | $178,500 | 0.01% |
| 164 | Nkarta, Inc. | NKTX | 28,988 | $173,638 | 0.01% |
| 165 | Fusion Pharmaceuticals Inc. | 36118A100 | 43,394 | $136,691 | 0.01% |
| 166 | ARCA biopharma, Inc. | 00211Y506 | 32,461 | $76,608 | 0.00% |
| 167 | Spectrum Pharmaceuticals, Inc. | 84763A108 | 114,670 | $42,256 | 0.00% |
| 168 | VYNE Therapeutics Inc. | VYNE | 135,395 | $20,309 | 0.00% |
| 169 | Corbus Pharmaceuticals Holdings, Inc. | CRBP | 154,310 | $17,051 | 0.00% |
| 170 | AlerisLife Inc. | 33832D205 | 24,237 | $13,330 | 0.00% |
| 171 | NexGel, Inc. | NXGLW | 4,243 | $5,304 | 0.00% |
| 172 | Bellicum Pharmaceuticals, Inc. | 079481404 | 6,000 | $4,320 | 0.00% |