13F HOLDINGS REPORT
RTW INVESTMENTS, LP
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001493215-26-000060
Total Value
$9.98B
Positions
91
Other Managers
0
Confidential Omitted
No
Holdings (91)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | MADRIGAL PHARMACEUTICALS INC | MDGL | 1,993,687 | $1.16B | 11.63% |
| 2 | INSMED INC | INSM | 4,842,879 | $842.9M | 8.44% |
| 3 | PTC THERAPEUTICS INC | PTCT | 7,746,415 | $588.4M | 5.89% |
| 4 | ARGENX SE | ARGX | 673,497 | $566.4M | 5.67% |
| 5 | PROTAGONIST THERAPEUTICS INC | PTGX | 5,059,053 | $441.9M | 4.43% |
| 6 | NATERA INC | NTRA | 1,500,000 | $343.6M | 3.44% |
| 7 | RADNET INC | RDNT | 3,938,500 | $281.0M | 2.81% |
| 8 | TARSUS PHARMACEUTICALS INC | TARS | 3,335,320 | $273.1M | 2.74% |
| 9 | COGENT BIOSCIENCES INC | COGT | 7,592,241 | $269.7M | 2.70% |
| 10 | PENUMBRA INC | PEN | 866,499 | $269.4M | 2.70% |
| 11 | IRHYTHM TECHNOLOGIES INC | IRTC | 1,181,990 | $209.7M | 2.10% |
| 12 | APOGEE THERAPEUTICS INC | APGE | 2,712,097 | $204.7M | 2.05% |
| 13 | APELLIS PHARMACEUTICALS INC | APLS | 7,666,764 | $192.6M | 1.93% |
| 14 | ACADIA PHARMACEUTICALS INC | ACAD | 7,144,524 | $190.8M | 1.91% |
| 15 | ESTABLISHMENT LABS HLDGS INC | ESTA | 2,588,831 | $188.7M | 1.89% |
| 16 | STOKE THERAPEUTICS INC | STOK | 5,546,856 | $176.1M | 1.76% |
| 17 | REPLIGEN CORP | RGEN | 1,064,000 | $174.3M | 1.75% |
| 18 | CYTOKINETICS INC | CYTK | 2,721,158 | $172.9M | 1.73% |
| 19 | IMMUNOCORE HLDGS PLC | IMCR | 4,869,798 | $169.0M | 1.69% |
| 20 | AXSOME THERAPEUTICS INC | AXSM | 888,001 | $162.2M | 1.62% |
| 21 | GUARDANT HEALTH INC | GH | 1,481,033 | $151.3M | 1.52% |
| 22 | NEUROCRINE BIOSCIENCES INC | NBIX | 1,062,072 | $150.6M | 1.51% |
| 23 | SPYRE THERAPEUTICS INC | SYRE | 4,171,996 | $136.7M | 1.37% |
| 24 | ZAI LAB LTD | ZLAB | 6,959,032 | $122.8M | 1.23% |
| 25 | IMMATICS N.V | IMTX | 11,433,354 | $120.1M | 1.20% |
| 26 | BELITE BIO INC | BLTE | 715,332 | $114.4M | 1.15% |
| 27 | UROGEN PHARMA LTD | URGN | 4,543,895 | $106.4M | 1.07% |
| 28 | XENCOR INC | XNCR | 6,777,461 | $103.8M | 1.04% |
| 29 | INSULET CORP | PODD | 324,600 | $92.3M | 0.92% |
| 30 | TAYSHA GENE THERAPIES INC | TSHA | 16,398,297 | $90.2M | 0.90% |
| 31 | MASIMO CORP | MASI | 683,294 | $88.9M | 0.89% |
| 32 | UNIQURE NV | QURE | 3,711,462 | $88.8M | 0.89% |
| 33 | STRYKER CORPORATION | SYK | 245,000 | $86.1M | 0.86% |
| 34 | CG ONCOLOGY INC | CGON | 2,012,127 | $83.5M | 0.84% |
| 35 | CASTLE BIOSCIENCES INC | CSTL | 2,115,237 | $82.3M | 0.82% |
| 36 | IMMUNOVANT INC | IMVT | 3,177,850 | $80.8M | 0.81% |
| 37 | BETA BIONICS INC | BBNX | 2,500,000 | $76.2M | 0.76% |
| 38 | GH RESEARCH PLC | GHRS | 5,933,815 | $75.4M | 0.75% |
| 39 | REPLIMUNE GROUP INC | REPL | 7,140,352 | $69.4M | 0.70% |
| 40 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 3,000,139 | $69.0M | 0.69% |
| 41 | CRINETICS PHARMACEUTICALS IN | CRNX | 1,351,326 | $62.9M | 0.63% |
| 42 | ORUKA THERAPEUTICS INC | ORKA | 2,058,148 | $62.4M | 0.62% |
| 43 | ROCKET PHARMACEUTICALS INC | RCKTW | 17,687,772 | $62.1M | 0.62% |
| 44 | COMPASS PATHWAYS PLC | CMPS | 8,757,390 | $60.4M | 0.61% |
| 45 | INTUITIVE SURGICAL INC | ISRG | 101,228 | $57.3M | 0.57% |
| 46 | RAPT THERAPEUTICS INC | 75382E208 | 1,637,165 | $55.5M | 0.56% |
| 47 | CELCUITY INC | CELC | 550,160 | $54.9M | 0.55% |
| 48 | VERASTEM INC | VSTM | 6,576,306 | $50.8M | 0.51% |
| 49 | ALKERMES PLC | ALKS | 1,672,356 | $46.8M | 0.47% |
| 50 | CENTESSA PHARMACEUTICALS PLC | CNTA | 1,790,837 | $44.8M | 0.45% |
| 51 | KODIAK SCIENCES INC | KOD | 1,487,933 | $41.6M | 0.42% |
| 52 | AQUESTIVE THERAPEUTICS INC | AQST | 6,250,000 | $40.4M | 0.40% |
| 53 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 584,716 | $38.8M | 0.39% |
| 54 | SAVARA INC | SVRA | 5,952,380 | $35.9M | 0.36% |
| 55 | ORCHESTRA BIOMED HLDGS INC | OBIO | 8,306,063 | $34.5M | 0.35% |
| 56 | NEUROGENE INC | NGNE | 1,362,456 | $28.1M | 0.28% |
| 57 | WAVE LIFE SCIENCES LTD | WVE | 1,350,000 | $22.9M | 0.23% |
| 58 | JADE BIOSCIENCES INC | JBIO | 1,449,273 | $22.4M | 0.22% |
| 59 | EVOMMUNE INC | EVMN | 1,283,671 | $22.0M | 0.22% |
| 60 | KYMERA THERAPEUTICS INC | KYMR | 240,000 | $18.7M | 0.19% |
| 61 | FULGENT GENETICS INC | FLGT | 705,027 | $18.5M | 0.19% |
| 62 | CULLINAN THERAPEUTICS INC | CGEM | 1,705,960 | $17.7M | 0.18% |
| 63 | HINGE HEALTH INC | HNGE | 353,500 | $16.4M | 0.16% |
| 64 | BEAM THERAPEUTICS INC | BEAM | 570,394 | $15.8M | 0.16% |
| 65 | HEARTFLOW INC | HTFL | 495,000 | $14.4M | 0.14% |
| 66 | COMPASS THERAPEUTICS INC | CMPX | 2,500,000 | $13.4M | 0.13% |
| 67 | TANGO THERAPEUTICS INC | TNGX | 1,491,228 | $13.2M | 0.13% |
| 68 | LUMEXA IMAGING HOLDINGS INC | LMRI | 650,000 | $12.0M | 0.12% |
| 69 | LARIMAR THERAPEUTICS INC | LRMR | 3,125,000 | $11.9M | 0.12% |
| 70 | TEMPUS AI INC | TEM | 200,000 | $11.8M | 0.12% |
| 71 | KALARIS THERAPEUTICS INC | KLRS | 1,300,000 | $11.0M | 0.11% |
| 72 | IQVIA HLDGS INC | IQV | 46,000 | $10.4M | 0.10% |
| 73 | PERCEPTIVE CAP SOLUTIONS COR | G70077105 | 742,500 | $9.7M | 0.10% |
| 74 | ATAI BECKLEY NV | N0731H103 | 2,000,000 | $8.2M | 0.08% |
| 75 | ALLURION TECHNOLOGIES INC | ALURW | 5,891,430 | $7.2M | 0.07% |
| 76 | CAPRICOR THERAPEUTICS INC | CAPR | 250,000 | $7.2M | 0.07% |
| 77 | STRUCTURE THERAPEUTICS INC | GPCR | 100,000 | $7.0M | 0.07% |
| 78 | INVENTIVA SA | IVEVF | 1,298,701 | $6.0M | 0.06% |
| 79 | MILESTONE PHARMACEUTICALS IN | MIST | 2,506,102 | $5.1M | 0.05% |
| 80 | EXAGEN INC | XGN | 790,462 | $4.8M | 0.05% |
| 81 | TENAX THERAPEUTICS INC | TENX | 378,346 | $4.6M | 0.05% |
| 82 | CRESCENT BIOPHARMA INC. | CBIO | 372,856 | $4.4M | 0.04% |
| 83 | MIND MEDICINE MINDMED INC | 60255C885 | 300,000 | $4.0M | 0.04% |
| 84 | 4D MOLECULAR THERAPEUTICS IN | FDMT | 475,737 | $3.6M | 0.04% |
| 85 | CORVUS PHARMACEUTICALS INC | CRVS | 447,607 | $3.4M | 0.03% |
| 86 | OMADA HEALTH INC | OMDA | 200,000 | $3.2M | 0.03% |
| 87 | MEDLINE INC | MDLN | 70,000 | $2.9M | 0.03% |
| 88 | DISC MEDICINE INC | IRON | 30,000 | $2.4M | 0.02% |
| 89 | IMAGENEBIO INC | IMA | 334,445 | $2.3M | 0.02% |
| 90 | ERASCA INC | ERAS | 146,651 | $545,542 | 0.01% |
| 91 | ROCKET PHARMACEUTICALS INC | RCKTW | 350,000 | $8,505 | 0.00% |