13F HOLDINGS REPORT
RTW INVESTMENTS, LP
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001493215-25-000054
Total Value
$8.12B
Positions
74
Other Managers
0
Confidential Omitted
No
Holdings (74)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | MADRIGAL PHARMACEUTICALS INC | MDGL | 1,993,687 | $914.4M | 11.27% |
| 2 | ARGENX SE | ARGX | 673,497 | $496.7M | 6.12% |
| 3 | AVIDITY BIOSCIENCES INC | 05370A108 | 11,372,829 | $495.5M | 6.11% |
| 4 | PTC THERAPEUTICS INC | PTCT | 7,746,415 | $475.4M | 5.86% |
| 5 | INSMED INC | INSM | 3,084,558 | $444.2M | 5.47% |
| 6 | PROTAGONIST THERAPEUTICS INC | PTGX | 5,756,277 | $382.4M | 4.71% |
| 7 | NATERA INC | NTRA | 2,000,000 | $321.9M | 3.97% |
| 8 | AKERO THERAPEUTICS INC | 00973Y108 | 5,477,561 | $260.1M | 3.20% |
| 9 | UNIQURE NV | QURE | 4,424,968 | $258.3M | 3.18% |
| 10 | PENUMBRA INC | PEN | 866,499 | $219.5M | 2.70% |
| 11 | RADNET INC | RDNT | 2,815,544 | $214.6M | 2.64% |
| 12 | MERUS N V | N5749R100 | 2,025,277 | $190.7M | 2.35% |
| 13 | TARSUS PHARMACEUTICALS INC | TARS | 3,177,436 | $188.8M | 2.33% |
| 14 | STRYKER CORPORATION | SYK | 490,000 | $181.1M | 2.23% |
| 15 | IMMUNOCORE HLDGS PLC | IMCR | 4,869,798 | $176.9M | 2.18% |
| 16 | ACADIA PHARMACEUTICALS INC | ACAD | 7,144,524 | $152.5M | 1.88% |
| 17 | CYTOKINETICS INC | CYTK | 2,721,158 | $149.6M | 1.84% |
| 18 | NEUROCRINE BIOSCIENCES INC | NBIX | 1,062,072 | $149.1M | 1.84% |
| 19 | AXSOME THERAPEUTICS INC | AXSM | 1,118,883 | $135.9M | 1.67% |
| 20 | STOKE THERAPEUTICS INC | STOK | 5,123,525 | $120.4M | 1.48% |
| 21 | APOGEE THERAPEUTICS INC | APGE | 2,712,097 | $107.8M | 1.33% |
| 22 | ESTABLISHMENT LABS HLDGS INC | ESTA | 2,588,831 | $106.1M | 1.31% |
| 23 | MASIMO CORP | MASI | 683,294 | $100.8M | 1.24% |
| 24 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 3,258,266 | $98.0M | 1.21% |
| 25 | GUARDANT HEALTH INC | GH | 1,481,033 | $92.5M | 1.14% |
| 26 | UROGEN PHARMA LTD | URGN | 4,543,895 | $90.7M | 1.12% |
| 27 | INTUITIVE SURGICAL INC | ISRG | 202,456 | $90.5M | 1.12% |
| 28 | GH RESEARCH PLC | GHRS | 5,569,564 | $79.6M | 0.98% |
| 29 | TAYSHA GENE THERAPIES INC | TSHA | 24,354,291 | $79.6M | 0.98% |
| 30 | ZAI LAB LTD | ZLAB | 2,291,372 | $77.7M | 0.96% |
| 31 | IMMATICS N.V | IMTX | 8,815,617 | $75.1M | 0.93% |
| 32 | XENCOR INC | XNCR | 6,221,054 | $73.0M | 0.90% |
| 33 | CG ONCOLOGY INC | CGON | 1,701,216 | $68.5M | 0.84% |
| 34 | BETA BIONICS INC | BBNX | 3,299,191 | $65.6M | 0.81% |
| 35 | SPYRE THERAPEUTICS INC | SYRE | 3,621,996 | $60.7M | 0.75% |
| 36 | ROCKET PHARMACEUTICALS INC | RCKTW | 17,687,772 | $57.7M | 0.71% |
| 37 | CENTESSA PHARMACEUTICALS PLC | CNTA | 2,291,747 | $55.6M | 0.68% |
| 38 | ALKERMES PLC | ALKS | 1,672,356 | $50.2M | 0.62% |
| 39 | COMPASS PATHWAYS PLC | CMPS | 8,707,390 | $49.9M | 0.61% |
| 40 | COGENT BIOSCIENCES INC | COGT | 3,467,486 | $49.8M | 0.61% |
| 41 | VERASTEM INC | VSTM | 5,426,306 | $47.9M | 0.59% |
| 42 | QUEST DIAGNOSTICS INC | DGX | 250,000 | $47.6M | 0.59% |
| 43 | LENZ THERAPEUTICS INC | LENZ | 863,389 | $40.2M | 0.50% |
| 44 | RAPT THERAPEUTICS INC | 75382E208 | 1,470,499 | $37.9M | 0.47% |
| 45 | ORUKA THERAPEUTICS INC | ORKA | 1,945,649 | $37.4M | 0.46% |
| 46 | DYNE THERAPEUTICS INC | DYN | 2,890,567 | $36.6M | 0.45% |
| 47 | CRINETICS PHARMACEUTICALS IN | CRNX | 872,387 | $36.3M | 0.45% |
| 48 | AQUESTIVE THERAPEUTICS INC | AQST | 6,250,000 | $34.9M | 0.43% |
| 49 | ABIVAX SA | AAVXF | 350,000 | $29.7M | 0.37% |
| 50 | GE HEALTHCARE TECHNOLOGIES I | GEHC | 393,500 | $29.6M | 0.36% |
| 51 | REPLIMUNE GROUP INC | REPL | 6,395,732 | $26.8M | 0.33% |
| 52 | NEUROGENE INC | NGNE | 1,362,456 | $23.6M | 0.29% |
| 53 | BELITE BIO INC | BLTE | 312,500 | $23.1M | 0.28% |
| 54 | ALECTOR INC | ALEC | 6,990,806 | $20.7M | 0.25% |
| 55 | ORCHESTRA BIOMED HLDGS INC | OBIO | 8,306,063 | $20.6M | 0.25% |
| 56 | CORVUS PHARMACEUTICALS INC | CRVS | 2,679,479 | $19.7M | 0.24% |
| 57 | EXAGEN INC | XGN | 1,696,866 | $18.6M | 0.23% |
| 58 | HEARTFLOW INC | HTFL | 495,000 | $16.7M | 0.21% |
| 59 | TEMPUS AI INC | TEM | 200,000 | $16.1M | 0.20% |
| 60 | JADE BIOSCIENCES INC | JBIO | 1,449,273 | $12.5M | 0.15% |
| 61 | CYTOMX THERAPEUTICS INC | CTMX | 3,461,500 | $11.0M | 0.14% |
| 62 | CULLINAN THERAPEUTICS INC | CGEM | 1,705,960 | $10.1M | 0.12% |
| 63 | LARIMAR THERAPEUTICS INC | LRMR | 3,125,000 | $10.1M | 0.12% |
| 64 | COMPASS THERAPEUTICS INC | CMPX | 2,500,000 | $8.8M | 0.11% |
| 65 | PERCEPTIVE CAP SOLUTIONS COR | G70077105 | 742,500 | $7.8M | 0.10% |
| 66 | PEPGEN INC | PEPG | 1,500,000 | $6.9M | 0.09% |
| 67 | WAVE LIFE SCIENCES LTD | WVE | 900,000 | $6.6M | 0.08% |
| 68 | ALLURION TECHNOLOGIES INC | ALURW | 2,542,603 | $5.2M | 0.06% |
| 69 | MILESTONE PHARMACEUTICALS IN | MIST | 2,506,102 | $5.0M | 0.06% |
| 70 | OMADA HEALTH INC | OMDA | 200,000 | $4.4M | 0.05% |
| 71 | TENAX THERAPEUTICS INC | TENX | 378,346 | $2.9M | 0.04% |
| 72 | IMAGENEBIO INC | IMA | 334,445 | $2.7M | 0.03% |
| 73 | ADAGIO MED HLDGS INC | 00534B100 | 209,361 | $406,160 | 0.01% |
| 74 | ROCKET PHARMACEUTICALS INC | RCKTW | 350,000 | $13,720 | 0.00% |