Live Markets
Wednesday, July 29, 2026·George Town, KY·29°·Partly Cloudy
Markets Open · NYSE·Newsletter·Masthead·
VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

RTW INVESTMENTS, LP

Quarter ended Q2 2025 · Filed August 14, 2025 · Accession 0001493215-25-000007

Total Value
$7.02B
Positions
73
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (73)

#IssuerTicker / CUSIPSharesValue% of Filing
1MADRIGAL PHARMACEUTICALS INCMDGL1,993,687$603.4M8.59%
2NATERA INCNTRA2,593,645$438.2M6.24%
3PTC THERAPEUTICS INCPTCT7,746,415$378.3M5.39%
4ARGENX SEARGX673,497$371.2M5.29%
5PROTAGONIST THERAPEUTICS INCPTGX5,756,277$318.1M4.53%
6INSMED INCINSM3,084,558$310.4M4.42%
7AKERO THERAPEUTICS INC00973Y1085,477,561$292.3M4.16%
8VERONA PHARMA PLC9250501063,051,878$288.6M4.11%
9AVIDITY BIOSCIENCES INC05370A1089,618,845$273.2M3.89%
10STRYKER CORPORATIONSYK590,517$233.6M3.33%
11PENUMBRA INCPEN863,553$221.6M3.16%
12MERUS N VN5749R1004,000,553$210.4M3.00%
13ACADIA PHARMACEUTICALS INCACAD8,995,547$194.0M2.76%
14ZAI LAB LTDZLAB5,536,876$193.6M2.76%
15AXSOME THERAPEUTICS INCAXSM1,516,903$158.3M2.26%
16RADNET INCRDNT2,690,344$153.1M2.18%
17IMMUNOCORE HLDGS PLCIMCR4,869,798$152.8M2.18%
18ALKERMES PLCALKS4,682,289$134.0M1.91%
19NEUROCRINE BIOSCIENCES INCNBIX1,062,072$133.5M1.90%
20TARSUS PHARMACEUTICALS INCTARS3,111,680$126.1M1.80%
21APOGEE THERAPEUTICS INCAPGE2,712,097$117.8M1.68%
22MASIMO CORPMASI683,294$114.9M1.64%
23ESTABLISHMENT LABS HLDGS INCESTA2,584,131$110.4M1.57%
24INTUITIVE SURGICAL INCISRG202,456$110.0M1.57%
25CYTOKINETICS INCCYTK2,721,158$89.9M1.28%
26QUEST DIAGNOSTICS INCDGX500,000$89.8M1.28%
27UNIQURE NVQURE5,158,231$71.9M1.02%
28GH RESEARCH PLCGHRS5,540,457$67.5M0.96%
29UROGEN PHARMA LTDURGN4,543,895$62.3M0.89%
30ULTRAGENYX PHARMACEUTICAL INRARE1,707,402$62.1M0.88%
31ABBOTT LABSABLZF444,000$60.4M0.86%
32STOKE THERAPEUTICS INCSTOK5,123,525$58.2M0.83%
33TAYSHA GENE THERAPIES INCTSHA25,021,584$57.8M0.82%
34SPYRE THERAPEUTICS INCSYRE3,621,996$54.2M0.77%
35BETA BIONICS INCBBNX3,299,191$48.0M0.68%
36GE HEALTHCARE TECHNOLOGIES IGEHC626,000$46.4M0.66%
37GUARDANT HEALTH INCGH856,501$44.6M0.63%
38CG ONCOLOGY INCCGON1,701,216$44.2M0.63%
39ROCKET PHARMACEUTICALS INCRCKTW17,687,772$43.3M0.62%
40IMMATICS N.VIMTX6,970,152$37.5M0.53%
41SOLENO THERAPEUTICS INCSLNO424,408$35.6M0.51%
42MOONLAKE IMMUNOTHERAPEUTICSMLTX741,090$35.0M0.50%
43TEMPUS AI INCTEM400,000$25.4M0.36%
44LENZ THERAPEUTICS INCLENZ863,389$25.3M0.36%
45COMPASS PATHWAYS PLCCMPS8,221,929$23.0M0.33%
46ORCHESTRA BIOMED HLDGS INCOBIO8,306,062$22.3M0.32%
47ORUKA THERAPEUTICS INCORKA1,945,649$21.8M0.31%
48NEUROGENE INCNGNE1,362,456$20.4M0.29%
49CENTESSA PHARMACEUTICALS PLCCNTA1,529,836$20.1M0.29%
5089BIO INC2825591031,967,527$19.3M0.28%
51REPLIMUNE GROUP INCREPL2,065,010$19.2M0.27%
52XENCOR INCXNCR2,402,883$18.9M0.27%
53VERASTEM INCVSTM4,251,616$17.6M0.25%
54DYNE THERAPEUTICS INCDYN1,690,567$16.1M0.23%
55JADE BIOSCIENCES INCJBIO1,449,273$14.5M0.21%
56CRINETICS PHARMACEUTICALS INCRNX467,000$13.4M0.19%
57CULLINAN THERAPEUTICS INCCGEM1,705,960$12.8M0.18%
58EXAGEN INCXGN1,696,866$11.8M0.17%
59RAPT THERAPEUTICS INC75382E2081,470,499$11.8M0.17%
60CORVUS PHARMACEUTICALS INCCRVS2,679,479$10.7M0.15%
61PERCEPTIVE CAP SOLUTIONS CORG70077105742,500$7.9M0.11%
62CYTOMX THERAPEUTICS INCCTMX3,461,500$7.9M0.11%
63ALLURION TECHNOLOGIES INCALURW2,542,603$6.2M0.09%
64WAVE LIFE SCIENCES LTDWVE900,000$5.8M0.08%
65CARGO THERAPEUTICS INC14179K1011,212,562$5.0M0.07%
66MILESTONE PHARMACEUTICALS INMIST2,506,102$4.9M0.07%
67OMADA HEALTH INCOMDA200,000$3.7M0.05%
68KESTRA MED TECHNOLOGIES LTDBEKE200,000$3.3M0.05%
69CERIBELL INCCBLL150,000$2.8M0.04%
70TENAX THERAPEUTICS INCTENX378,346$2.2M0.03%
71IMMUNIC INCIMUX402,107$280,4700.00%
72ADAGIO MED HLDGS INC00534B100209,361$272,1690.00%
73ROCKET PHARMACEUTICALS INCRCKTW350,000$10,0800.00%