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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

RTW INVESTMENTS, LP

Quarter ended Q1 2025 · Filed May 15, 2025 · Accession 0001493215-25-000003

Total Value
$6.54B
Positions
68
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (68)

#IssuerTicker / CUSIPSharesValue% of Filing
1MADRIGAL PHARMACEUTICALS INCMDGL1,993,687$660.4M10.10%
2ARGENX SEARGX673,497$398.6M6.10%
3PTC THERAPEUTICS INCPTCT7,483,127$381.3M5.83%
4NATERA INCNTRA2,593,546$366.8M5.61%
5AXSOME THERAPEUTICS INCAXSM2,922,729$340.9M5.21%
6AKERO THERAPEUTICS INC00973Y1087,419,340$300.3M4.59%
7PROTAGONIST THERAPEUTICS INCPTGX5,719,415$276.6M4.23%
8AVIDITY BIOSCIENCES INC05370A1088,746,926$258.2M3.95%
9PENUMBRA INCPEN862,770$230.7M3.53%
10INSMED INCINSM3,014,558$230.0M3.52%
11ALKERMES PLCALKS6,884,698$227.3M3.48%
12STRYKER CORPORATIONSYK590,221$219.7M3.36%
13VERONA PHARMA PLC9250501062,848,800$180.9M2.77%
14MERUS N VN5749R1004,169,393$175.5M2.68%
15TARSUS PHARMACEUTICALS INCTARS3,316,032$170.3M2.61%
16IMMUNOCORE HLDGS PLCIMCR4,869,798$144.5M2.21%
17ACADIA PHARMACEUTICALS INCACAD8,540,117$141.9M2.17%
18ROCKET PHARMACEUTICALS INCRCKTW17,687,772$118.0M1.80%
19RADNET INCRDNT2,317,582$115.2M1.76%
20MASIMO CORPMASI683,294$113.8M1.74%
21ZAI LAB LTDZLAB3,136,680$113.4M1.73%
22CYTOKINETICS INCCYTK2,721,158$109.4M1.67%
23ESTABLISHMENT LABS HLDGS INCESTA2,583,887$105.4M1.61%
24APOGEE THERAPEUTICS INCAPGE2,712,097$101.3M1.55%
25INTUITIVE SURGICAL INCISRG202,456$100.3M1.53%
26GLOBUS MED INCGMED1,125,000$82.3M1.26%
27ULTRAGENYX PHARMACEUTICAL INRARE1,707,402$61.8M0.95%
28GH RESEARCH PLCGHRS5,499,769$60.7M0.93%
29SPYRE THERAPEUTICS INCSYRE3,621,996$58.4M0.89%
30UNIQURE NVQURE4,265,428$45.2M0.69%
31UROGEN PHARMA LTDURGN3,834,794$42.4M0.65%
32GE HEALTHCARE TECHNOLOGIES IGEHC520,000$42.0M0.64%
33CG ONCOLOGY INCCGON1,701,216$41.7M0.64%
34BETA BIONICS INCBBNX3,299,870$40.4M0.62%
35ORCHESTRA BIOMED HLDGS INCOBIO8,206,162$35.1M0.54%
36STOKE THERAPEUTICS INCSTOK5,123,525$34.1M0.52%
37IMMATICS N.VIMTX6,909,510$31.2M0.48%
38TAYSHA GENE THERAPIES INCTSHA18,787,866$26.1M0.40%
39VERASTEM INCVSTM4,245,476$25.6M0.39%
40XENCOR INCXNCR2,402,883$25.6M0.39%
41ARVINAS INCARVN3,334,308$23.4M0.36%
42LENZ THERAPEUTICS INCLENZ863,389$22.2M0.34%
43REPLIMUNE GROUP INCREPL2,065,010$20.1M0.31%
44ORUKA THERAPEUTICS INCORKA1,945,649$20.0M0.31%
45TEMPUS AI INCTEM400,000$19.3M0.30%
46GLAUKOS CORPGKOS190,000$18.7M0.29%
47DYNE THERAPEUTICS INCDYN1,690,567$17.7M0.27%
48CARGO THERAPEUTICS INC14179K1014,124,859$16.8M0.26%
49QUEST DIAGNOSTICS INCDGX98,997$16.8M0.26%
50COMPASS PATHWAYS PLCCMPS5,538,168$15.8M0.24%
51NEUROGENE INCNGNE1,348,656$15.8M0.24%
52RAPT THERAPEUTICS INC75382E10911,764,000$14.4M0.22%
5389BIO INC2825591031,967,527$14.3M0.22%
54CULLINAN THERAPEUTICS INCCGEM1,705,960$12.9M0.20%
55BEAM THERAPEUTICS INCBEAM438,659$8.6M0.13%
56CORVUS PHARMACEUTICALS INCCRVS2,679,479$8.5M0.13%
57PERCEPTIVE CAP SOLUTIONS CORG70077105742,500$7.6M0.12%
58WAVE LIFE SCIENCES LTDWVE900,000$7.3M0.11%
59EXAGEN INCXGN1,511,866$5.4M0.08%
60KESTRA MED TECHNOLOGIES LTDBEKE200,000$5.0M0.08%
61ALLURION TECHNOLOGIES INCALURW1,050,063$3.4M0.05%
62BIOAGE LABS INCBIOA786,353$3.0M0.05%
63CERIBELL INCCBLL150,000$2.9M0.04%
64TENAX THERAPEUTICS INCTENX378,346$2.5M0.04%
65MILESTONE PHARMACEUTICALS INMIST2,506,102$2.0M0.03%
66CENTESSA PHARMACEUTICALS PLCCNTA50,000$719,0000.01%
67ADAGIO MED HLDGS INC00534B100209,361$168,5150.00%
68ROCKET PHARMACEUTICALS INCRCKTW350,000$16,4500.00%