13F HOLDINGS REPORT
Palo Alto Investors LP
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001306923-25-000019
Total Value
$540.4M
Positions
44
Other Managers
0
Confidential Omitted
No
Holdings (44)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | INSMED INC | INSM | 491,805 | $70.8M | 13.11% |
| 2 | PTC THERAPEUTICS INC | PTCT | 862,613 | $52.9M | 9.80% |
| 3 | ACADIA PHARMACEUTICALS INC | ACAD | 2,466,684 | $52.6M | 9.74% |
| 4 | AMICUS THERAPEUTICS INC | FOLD | 5,367,798 | $42.3M | 7.83% |
| 5 | BIOMARIN PHARMACEUTICAL INC | BMRN | 754,007 | $40.8M | 7.56% |
| 6 | BIOGEN INC | BIIB | 185,661 | $26.0M | 4.81% |
| 7 | UNITED THERAPEUTICS CORP | UTHR | 58,186 | $24.4M | 4.51% |
| 8 | ANAPTYSBIO INC | ANABV | 673,520 | $20.6M | 3.82% |
| 9 | IOVANCE BIOTHERAPEUTICS INC | IOVA | 7,618,132 | $16.5M | 3.06% |
| 10 | NOVOCURE LTD | NVCR | 1,256,159 | $16.2M | 3.00% |
| 11 | DYNE THERAPEUTICS INC | DYN | 1,262,674 | $16.0M | 2.96% |
| 12 | DISC MEDICINE INC | IRON | 224,300 | $14.8M | 2.74% |
| 13 | ALNYLAM PHARMACEUTICALS INC | ALNY | 32,320 | $14.7M | 2.73% |
| 14 | GOSSAMER BIO INC | GOSS | 5,464,349 | $14.4M | 2.66% |
| 15 | PROTHENA CORP PLC | PRTA | 1,324,028 | $12.9M | 2.39% |
| 16 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 369,531 | $11.1M | 2.06% |
| 17 | AGIOS PHARMACEUTICALS INC | AGIO | 265,497 | $10.7M | 1.97% |
| 18 | SYNDAX PHARMACEUTICALS INC | SNDX | 654,930 | $10.1M | 1.86% |
| 19 | EHEALTH INC | EHTH | 1,544,619 | $6.7M | 1.23% |
| 20 | DENALI THERAPEUTICS INC | DNLI | 408,006 | $5.9M | 1.10% |
| 21 | ALIGN TECHNOLOGY INC | ALGN | 45,735 | $5.7M | 1.06% |
| 22 | ALKERMES PLC | ALKS | 183,938 | $5.5M | 1.02% |
| 23 | AVIDITY BIOSCIENCES INC | 05370A108 | 109,831 | $4.8M | 0.89% |
| 24 | MIRUM PHARMACEUTICALS INC | MIRM | 64,700 | $4.7M | 0.88% |
| 25 | CAREDX INC | CDNA | 316,204 | $4.6M | 0.85% |
| 26 | TAYSHA GENE THERAPIES INC | TSHA | 1,246,033 | $4.1M | 0.75% |
| 27 | NUVATION BIO INC | NUVB | 1,020,547 | $3.8M | 0.70% |
| 28 | ACLARIS THERAPEUTICS INC | ACRS | 1,566,840 | $3.0M | 0.55% |
| 29 | CRISPR THERAPEUTICS AG | CRSP | 41,226 | $2.7M | 0.49% |
| 30 | TRAVERE THERAPEUTICS INC | TVTX | 110,719 | $2.6M | 0.49% |
| 31 | EDWARDS LIFESCIENCES CORP | EW | 33,640 | $2.6M | 0.48% |
| 32 | NEUROCRINE BIOSCIENCES INC | NBIX | 18,117 | $2.5M | 0.47% |
| 33 | STOKE THERAPEUTICS INC | STOK | 105,427 | $2.5M | 0.46% |
| 34 | PYXIS ONCOLOGY INC | PYXS | 1,037,421 | $2.3M | 0.43% |
| 35 | BIONTECH SE-ADR | BNTX | 19,614 | $1.9M | 0.36% |
| 36 | BICYCLE THERAPEUTICS PLC-ADR | BCYC | 221,071 | $1.7M | 0.32% |
| 37 | ALDEYRA THERAPEUTICS INC | ALDX | 225,465 | $1.2M | 0.22% |
| 38 | HUMANA INC | HUM | 3,985 | $1.0M | 0.19% |
| 39 | ORUKA THERAPEUTICS INC | ORKA | 59,985 | $791,310 | 0.15% |
| 40 | ABEONA THERAPEUTICS INC | ABEO | 108,865 | $574,807 | 0.11% |
| 41 | UROGEN PHARMA LTD | URGN | 24,500 | $488,775 | 0.09% |
| 42 | PROQR THERAPEUTICS NV | N71542109 | 188,807 | $402,159 | 0.07% |
| 43 | AKARI THERAPEUTICS PLC-ADR | AKTX | 146,024 | $147,484 | 0.03% |
| 44 | GENERATION BIO CO | 37148K100 | 15,047 | $92,088 | 0.02% |