13F HOLDINGS REPORT
Palo Alto Investors LP
Quarter ended Q2 2025 · Filed August 14, 2025 · Accession 0001306923-25-000016
Total Value
$470.0M
Positions
45
Other Managers
0
Confidential Omitted
No
Holdings (45)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | INSMED INC | INSM | 865,113 | $87.1M | 18.52% |
| 2 | ACADIA PHARMACEUTICALS INC | ACAD | 2,563,209 | $55.3M | 11.76% |
| 3 | BIOMARIN PHARMACEUTICAL INC | BMRN | 840,470 | $46.2M | 9.83% |
| 4 | AMICUS THERAPEUTICS INC | FOLD | 5,610,513 | $32.1M | 6.84% |
| 5 | UNITED THERAPEUTICS CORP | UTHR | 95,482 | $27.4M | 5.84% |
| 6 | BIOGEN INC | BIIB | 205,759 | $25.8M | 5.50% |
| 7 | ALNYLAM PHARMACEUTICALS INC | ALNY | 75,535 | $24.6M | 5.24% |
| 8 | PTC THERAPEUTICS INC | PTCT | 406,469 | $19.9M | 4.22% |
| 9 | ANAPTYSBIO INC | ANABV | 812,821 | $18.0M | 3.84% |
| 10 | NOVOCURE LTD | NVCR | 962,396 | $17.1M | 3.64% |
| 11 | STAAR SURGICAL CO | STAA | 791,879 | $13.3M | 2.83% |
| 12 | AGIOS PHARMACEUTICALS INC | AGIO | 268,783 | $8.9M | 1.90% |
| 13 | PROTHENA CORP PLC | PRTA | 1,274,753 | $7.7M | 1.65% |
| 14 | DISC MEDICINE INC | IRON | 145,691 | $7.7M | 1.64% |
| 15 | ALIGN TECHNOLOGY INC | ALGN | 37,772 | $7.2M | 1.52% |
| 16 | GOSSAMER BIO INC | GOSS | 5,739,013 | $7.1M | 1.50% |
| 17 | EHEALTH INC | EHTH | 1,577,850 | $6.9M | 1.46% |
| 18 | ALKERMES PLC | ALKS | 221,021 | $6.3M | 1.35% |
| 19 | IOVANCE BIOTHERAPEUTICS INC | IOVA | 3,429,329 | $5.9M | 1.25% |
| 20 | SYNDAX PHARMACEUTICALS INC | SNDX | 444,367 | $4.2M | 0.89% |
| 21 | AVIDITY BIOSCIENCES INC | 05370A108 | 118,886 | $3.4M | 0.72% |
| 22 | DENALI THERAPEUTICS INC | DNLI | 239,809 | $3.4M | 0.71% |
| 23 | MIRUM PHARMACEUTICALS INC | MIRM | 64,700 | $3.3M | 0.70% |
| 24 | EDWARDS LIFESCIENCES CORP | EW | 39,473 | $3.1M | 0.66% |
| 25 | TAYSHA GENE THERAPIES INC | TSHA | 1,246,033 | $2.9M | 0.61% |
| 26 | BIONTECH SE-ADR | BNTX | 25,206 | $2.7M | 0.57% |
| 27 | DYNE THERAPEUTICS INC | DYN | 264,976 | $2.5M | 0.54% |
| 28 | CRISPR THERAPEUTICS AG | CRSP | 44,625 | $2.2M | 0.46% |
| 29 | ACLARIS THERAPEUTICS INC | ACRS | 1,390,028 | $2.0M | 0.42% |
| 30 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 48,750 | $1.8M | 0.38% |
| 31 | BICYCLE THERAPEUTICS PLC-ADR | BCYC | 248,934 | $1.7M | 0.37% |
| 32 | NEUROCRINE BIOSCIENCES INC | NBIX | 13,334 | $1.7M | 0.36% |
| 33 | TRAVERE THERAPEUTICS INC | TVTX | 110,719 | $1.6M | 0.35% |
| 34 | NUVATION BIO INC | NUVB | 772,652 | $1.5M | 0.32% |
| 35 | STOKE THERAPEUTICS INC | STOK | 125,861 | $1.4M | 0.30% |
| 36 | PYXIS ONCOLOGY INC | PYXS | 1,037,421 | $1.1M | 0.24% |
| 37 | HUMANA INC | HUM | 3,985 | $974,253 | 0.21% |
| 38 | ALDEYRA THERAPEUTICS INC | ALDX | 225,465 | $863,531 | 0.18% |
| 39 | KARYOPHARM THERAPEUTICS INC | KPTI | 187,911 | $809,896 | 0.17% |
| 40 | VYNE THERAPEUTICS INC PIPE | VYNE | 445,434 | $734,966 | 0.16% |
| 41 | ABEONA THERAPEUTICS INC | ABEO | 108,865 | $618,353 | 0.13% |
| 42 | ALUMIS INC | ALMS | 143,437 | $430,311 | 0.09% |
| 43 | UROGEN PHARMA LTD | URGN | 24,500 | $335,650 | 0.07% |
| 44 | AKARI THERAPEUTICS PLC-ADR | AKTX | 146,024 | $170,834 | 0.04% |
| 45 | GENERATION BIO CO | 37148K100 | 150,475 | $48,167 | 0.01% |