Live Markets
Wednesday, July 29, 2026·George Town, KY·29°·Partly Cloudy
Markets Open · NYSE·Newsletter·Masthead·
VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

Palo Alto Investors LP

Quarter ended Q1 2025 · Filed May 15, 2025 · Accession 0001306923-25-000014

Total Value
$525.1M
Positions
44
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (44)

#IssuerTicker / CUSIPSharesValue% of Filing
1INSMED INCINSM987,153$75.3M14.34%
2BIOMARIN PHARMACEUTICAL INCBMRN991,207$70.1M13.34%
3AMICUS THERAPEUTICS INCFOLD7,345,002$59.9M11.41%
4ACADIA PHARMACEUTICALS INCACAD2,663,925$44.2M8.43%
5UNITED THERAPEUTICS CORPUTHR105,228$32.4M6.18%
6BIOGEN INCBIIB204,923$28.0M5.34%
7ALNYLAM PHARMACEUTICALS INCALNY83,488$22.5M4.29%
8PTC THERAPEUTICS INCPTCT404,196$20.6M3.92%
9PROTHENA CORP PLCPRTA1,659,734$20.5M3.91%
10ANAPTYSBIO INCANABV1,020,713$19.0M3.61%
11NOVOCURE LTDNVCR1,002,061$17.9M3.40%
12SAREPTA THERAPEUTICS INCSRPT210,258$13.4M2.56%
13EHEALTH INCEHTH1,684,336$11.3M2.14%
14IOVANCE BIOTHERAPEUTICS INCIOVA3,211,314$10.7M2.04%
15STAAR SURGICAL COSTAA525,017$9.3M1.76%
16AGIOS PHARMACEUTICALS INCAGIO276,578$8.1M1.54%
17ALKERMES PLCALKS221,513$7.3M1.39%
18GOSSAMER BIO INCGOSS6,276,893$6.9M1.31%
19ALIGN TECHNOLOGY INCALGN37,772$6.0M1.14%
20SYNDAX PHARMACEUTICALS INCSNDX444,367$5.5M1.04%
21ACELYRIN INC00445A1001,792,895$4.4M0.84%
22DYNE THERAPEUTICS INCDYN333,391$3.5M0.66%
23MIRUM PHARMACEUTICALS INCMIRM64,700$2.9M0.56%
24EDWARDS LIFESCIENCES CORPEW39,473$2.9M0.54%
25VERVE THERAPEUTICS INC92539P101575,817$2.6M0.50%
26BIONTECH SE-ADRBNTX25,206$2.3M0.44%
27BICYCLE THERAPEUTICS PLC-ADRBCYC248,934$2.1M0.40%
28TRAVERE THERAPEUTICS INCTVTX110,719$2.0M0.38%
29TAYSHA GENE THERAPIES INCTSHA1,419,468$2.0M0.38%
30NEUROCRINE BIOSCIENCES INCNBIX13,334$1.5M0.28%
31NUVATION BIO INCNUVB772,652$1.4M0.26%
32ALDEYRA THERAPEUTICS INCALDX225,465$1.3M0.25%
33KARYOPHARM THERAPEUTICS INCKPTI324,032$1.2M0.23%
34ACLARIS THERAPEUTICS INCACRS776,028$1.2M0.23%
35HUMANA INCHUM3,985$1.1M0.20%
36PYXIS ONCOLOGY INCPYXS1,037,421$1.0M0.19%
37STOKE THERAPEUTICS INCSTOK125,861$836,9760.16%
38VYNE THERAPEUTICS INC PIPEVYNE445,434$703,7860.13%
39ABEONA THERAPEUTICS INCABEO108,865$518,1970.10%
40UROGEN PHARMA LTDURGN24,500$270,9700.05%
41INSTIL BIO INCTIL11,165$193,8240.04%
42AKARI THERAPEUTICS PLC-ADRAKTX146,024$181,0700.03%
43RELMADA THERAPEUTICS INCRLMD495,146$133,6890.03%
44GENERATION BIO CO37148K100150,475$60,9420.01%