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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

Palo Alto Investors LP

Quarter ended Q4 2024 · Filed February 14, 2025 · Accession 0001306923-25-000010

Total Value
$645.4M
Positions
43
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (43)

#IssuerTicker / CUSIPSharesValue% of Filing
1INSMED INCINSM1,603,465$110.7M17.15%
2AMICUS THERAPEUTICS INCFOLD7,662,479$72.2M11.18%
3BIOMARIN PHARMACEUTICAL INCBMRN1,067,266$70.2M10.87%
4UNITED THERAPEUTICS CORPUTHR155,714$54.9M8.51%
5ACADIA PHARMACEUTICALS INCACAD2,748,599$50.4M7.82%
6ALNYLAM PHARMACEUTICALS INCALNY140,681$33.1M5.13%
7BIOGEN INCBIIB190,148$29.1M4.51%
8SAREPTA THERAPEUTICS INCSRPT210,258$25.6M3.96%
9NOVOCURE LTDNVCR814,191$24.3M3.76%
10PROTHENA CORP PLCPRTA1,737,964$24.1M3.73%
11IOVANCE BIOTHERAPEUTICS INCIOVA3,041,685$22.5M3.49%
12EHEALTH INCEHTH1,878,127$17.7M2.74%
13PTC THERAPEUTICS INCPTCT386,413$17.4M2.70%
14STAAR SURGICAL COSTAA500,775$12.2M1.88%
15ANAPTYSBIO INCANABV843,971$11.2M1.73%
16ALKERMES PLCALKS289,308$8.3M1.29%
17ALIGN TECHNOLOGY INCALGN37,772$7.9M1.22%
18GOSSAMER BIO INCGOSS6,277,093$5.7M0.88%
19ACELYRIN INC00445A1001,792,895$5.6M0.87%
20SYNDAX PHARMACEUTICALS INCSNDX405,193$5.4M0.83%
21BICYCLE THERAPEUTICS PLC-ADRBCYC248,934$3.5M0.54%
22KARYOPHARM THERAPEUTICS INCKPTI4,907,001$3.3M0.51%
23VERVE THERAPEUTICS INC92539P101575,817$3.2M0.50%
24EDWARDS LIFESCIENCES CORPEW39,473$2.9M0.45%
25BIONTECH SE-ADRBNTX25,206$2.9M0.45%
26NEVRO CORP64157F103750,371$2.8M0.43%
27MIRUM PHARMACEUTICALS INCMIRM64,700$2.7M0.41%
28NUVATION BIO INCNUVB772,652$2.1M0.32%
29TRAVERE THERAPEUTICS INCTVTX110,719$1.9M0.30%
30PYXIS ONCOLOGY INCPYXS1,037,421$1.6M0.25%
31VYNE THERAPEUTICS INC PIPEVYNE445,434$1.5M0.23%
32ACLARIS THERAPEUTICS INCACRS569,832$1.4M0.22%
33TAYSHA GENE THERAPIES INCTSHA811,268$1.4M0.22%
34STOKE THERAPEUTICS INCSTOK125,861$1.4M0.22%
35ALDEYRA THERAPEUTICS INCALDX225,465$1.1M0.17%
36HUMANA INCHUM3,985$1.0M0.16%
37JASPER THERAPEUTICS INCJSPRW30,651$655,3180.10%
38ABEONA THERAPEUTICS INCABEO108,865$606,3780.09%
39UROGEN PHARMA LTDURGN24,500$260,9250.04%
40RELMADA THERAPEUTICS INCRLMD495,146$257,4760.04%
41INSTIL BIO INCTIL11,165$213,1400.03%
42AKARI THERAPEUTICS PLC-ADRAKTX146,024$178,1490.03%
43GENERATION BIO CO37148K100150,475$159,5040.02%